公开(公告)号：US06756018B2

公开(公告)日：2004-06-29

申请号：US09782544

申请日：2001-02-12

申请人： Ken A. Nishimura ,  Danny E. Mars

发明人： Ken A. Nishimura ,  Danny E. Mars

IPC分类号： B01L302

CPC分类号： B01L3/50273 ,  B01J19/0093 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/046 ,  F15C1/14 ,  Y10T436/25 ,  Y10T436/2575 ,  Y10T436/25875

摘要： A microfluidic system for steering subject materials to a next processing region includes a substrate having at least one embedded gas generator that is activated in response to the result of an initial process, whereby a gas is formed having pressure to steer the subject materials to the next processing region. The gas generator includes resistors that are electrically activated. As current passes through the resistors, thermal energy is released to decompose a selected material from a solid or liquid state to gaseous state. In an alternative embodiment, a gas generator is activated in response to an external control.

摘要翻译： 用于将主体材料转向下一个处理区域的微流体系统包括具有至少一个嵌入式气体发生器的基板，其响应于初始过程的结果被激活，由此形成气体以将主体材料转向下一个 处理区域。 气体发生器包括电活动的电阻器。 当电流通过电阻器时，释放热能将所选择的材料从固态或液态分解成气态。 在替代实施例中，气体发生器响应于外部控制被激活。

公开(公告)号：US20040058407A1

公开(公告)日：2004-03-25

申请号：US10457015

申请日：2003-06-05

发明人： Scott E. Miller ,  Sean J. LeBlanc ,  Seth T. Rodgers ,  Andrey J. Zarur

IPC分类号： C12M001/34

CPC分类号： B01L3/502715 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/046 ,  G01N2021/0346

摘要： Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.

摘要翻译： 本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。 如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。 芯片可以含有体积小于约1ml的反应位点。 在一些实施例中，芯片可以以能够支撑活细胞的方式构造。 该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。 其他促进反应可能包括化学或生物物种的生产或消费。 在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

公开(公告)号：US20020042125A1

公开(公告)日：2002-04-11

申请号：US10005685

申请日：2001-11-07

申请人： Cepheid

发明人： Kurt E. Petersen ,  William A. McMillan ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T.A. Kovacs ,  M. Allen Northrup

IPC分类号： C12M001/34

CPC分类号： G01N30/6095 ,  B01J2219/00432 ,  B01J2219/00529 ,  B01L3/502715 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/0636 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/1827 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/086 ,  C12M47/02 ,  C12M47/06 ,  C40B60/14 ,  G01N30/6091 ,  Y10T436/25375 ,  Y10T436/255

摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.

摘要翻译： 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。

公开(公告)号：US20010054778A1

公开(公告)日：2001-12-27

申请号：US09796378

申请日：2001-02-28

发明人： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC分类号： B29C051/00 ,  C09J005/00 ,  B27N003/08

CPC分类号： B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

摘要翻译： 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有第二凸起突起，所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上，使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。

公开(公告)号：US6136212A

公开(公告)日：2000-10-24

申请号：US907184

申请日：1997-08-06

申请人： Carlos H. Mastrangelo ,  Piu F. Man ,  James R. Webster

发明人： Carlos H. Mastrangelo ,  Piu F. Man ,  James R. Webster

IPC分类号： B01J19/00 ,  B01L3/00 ,  B41J2/16 ,  B81B1/00 ,  G03F7/00 ,  G03F7/40 ,  B44C1/22

CPC分类号： B81C1/00071 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B41J2/1603 ,  B41J2/1623 ,  B41J2/1628 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1639 ,  B41J2/1642 ,  B41J2/1645 ,  G03F7/00 ,  G03F7/40 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01L2200/12 ,  B01L2400/0442 ,  B01L2400/046 ,  B01L2400/0655 ,  B01L2400/0688 ,  H01L2224/48091 ,  H01L2924/10155

摘要： The present invention relates to polymer-based micro-electro-mechanical system (MEMS) technology suitable for the fabrication of integrated microfluidic systems, particularly medical and chemical diagnostics system, ink-jet printer head, as well as any devices that requires liquid- or gas-filled cavities for operation. The integrated microfluidic systems may consist of pumps, valves, channels, reservoirs cavities, reaction chambers, mixers, heaters, fluidic interconnects, diffusers, nozzles, and other microfluidic components on top of a regular circuit substrate. This technology is vastly superior than any alternatives available such as glass-based, polysilicon-based MEMS technology as well as hybrid `circuit board` technology because of its simple construction low cost, low temperature processing, and its ability to integrate any electronic circuitry easily along with the fluidic parts.

摘要翻译： 本发明涉及适用于制造集成微流体系统，特别是医疗和化学诊断系统，喷墨打印机头的聚合物基微机电系统（MEMS）技术，以及任何需要液体或 充气腔用于操作。 集成的微流体系统可以由常规电路衬底顶部的泵，阀，通道，储存器腔，反应室，混合器，加热器，流体互连，扩散器，喷嘴和其它微流体组件组成。 由于其简单的构造，低成本，低温度处理以及易于集成任何电子电路的能力，该技术比诸如基于玻璃，基于多晶硅的MEMS技术以及混合“电路板” 以及流体部件。

公开(公告)号：US20150276089A1

公开(公告)日：2015-10-01

申请号：US14188664

申请日：2014-02-24

申请人： California Institute of Technology

发明人： Marc Alexander Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

IPC分类号： F16K99/00

CPC分类号： B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08986630B2

公开(公告)日：2015-03-24

申请号：US13822634

申请日：2012-09-25

申请人： Sekisui Chemical Co., Ltd.

发明人： Yoshinori Akagi ,  Shigeru Nomura

IPC分类号： C06B43/00 ,  B82B1/00 ,  C06D5/00 ,  B01L3/00

CPC分类号： C06B43/00 ,  B01L3/50273 ,  B01L2400/046 ,  B82B1/00 ,  C06D5/00 ,  C06D5/04 ,  F04B19/24 ,  Y10T137/0396

摘要： Provided is a gas-generating material which can generate a gas in a large amount per unit time and has high storage stability.The gas-generating material 11a according to the present invention comprises a gas-generating agent that is an azo compound or an azide compound, a tertiary amine, a photosensitizing agent and a binder resin.

摘要翻译： 本发明提供一种能够每单位时间产生大量气体并具有高储存稳定性的气体发生材料。 根据本发明的气体发生材料11a包括作为偶氮化合物或叠氮化合物的气体发生剂，叔胺，光敏剂和粘合剂树脂。

公开(公告)号：US08771612B2

公开(公告)日：2014-07-08

申请号：US12920884

申请日：2009-03-11

申请人： Masateru Fukuoka ,  Kazuki Yamamoto ,  Yoshinori Akagi ,  Hiroji Fukui

发明人： Masateru Fukuoka ,  Kazuki Yamamoto ,  Yoshinori Akagi ,  Hiroji Fukui

IPC分类号： B01L3/00 ,  C06B45/10 ,  C06B45/12

CPC分类号： B01L3/50273 ,  B01L2300/0887 ,  B01L2400/046 ,  F04B19/006 ,  Y10T137/2082

摘要： The present invention provides a photoresponsive gas-generating material that is to be used in a micropump of a microfluid device having fine channels formed therein, and is capable of effectively generating gases for transporting a microfluid in response to light irradiation and transporting the microfluid at an improved transport efficiency. The present invention also provides a micropump incorporating the photoresponsive gas-generating material.A photoresponsive gas-generating material 13 is to be used in a micropump having fine channels formed in a substrate, and comprises a photo-sensitive acid-generating agent and an acid-sensitive gas-generating agent, and a micropump 10 has the photoresponsive gas-generating material 13 housed therein.

摘要翻译： 本发明提供一种光反应性气体发生材料，其用于具有形成在其中的细通道的微流体装置的微型泵中，并且能够有效地产生用于响应于光照射输送微流体的气体，并在 提高运输效率。 本发明还提供了一种结合光响应气体发生材料的微型泵。 光响应性气体发生材料13用于形成在基板上的细通道的微型泵中，并且包含光敏酸产生剂和酸敏感气体发生剂，微泵10具有光响应气体 其中容纳有生产材料13。

公开(公告)号：US20140161687A1

公开(公告)日：2014-06-12

申请号：US13822634

申请日：2012-09-25

申请人： SEKISUI CHEMICAL CO., LTD.

发明人： Yoshinori Akagi ,  Shigeru Nomura

IPC分类号： C06B43/00 ,  B01L3/00

CPC分类号： C06B43/00 ,  B01L3/50273 ,  B01L2400/046 ,  B82B1/00 ,  C06D5/00 ,  C06D5/04 ,  F04B19/24 ,  Y10T137/0396

摘要： Provided is a gas-generating material which can generate a gas in a large amount per unit time and has high storage stability.The gas-generating material 11a according to the present invention comprises a gas-generating agent that is an azo compound or an azide compound, a tertiary amine, a photosensitizing agent and a binder resin.

摘要翻译： 本发明提供一种能够每单位时间产生大量气体并具有高储存稳定性的气体发生材料。 根据本发明的气体发生材料11a包括作为偶氮化合物或叠氮化合物的气体发生剂，叔胺，光敏剂和粘合剂树脂。

公开(公告)号：US08679827B2

公开(公告)日：2014-03-25

申请号：US13495224

申请日：2012-06-13

申请人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

发明人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

IPC分类号： C12M3/00

CPC分类号： G01N33/543 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N35/08 ,  G01N2035/0436

摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

摘要翻译： 本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在 说导管。 包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。 所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。