-
公开(公告)号：US20190018006A1
公开(公告)日：2019-01-17
申请号：US15977951
申请日：2018-05-11
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC: G01N33/543 , G01N35/00 , C40B40/10 , C40B40/06
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G01N2035/00158 , G01N2035/00168 , G01N2035/00326 , G01N2035/1034
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
-
公开(公告)号：US20180106795A1
公开(公告)日：2018-04-19
申请号：US15556482
申请日：2016-03-14
Applicant: VIBRANT HOLDINGS, LLC
Inventor： John J. Rajasekaran , Tianhao Wang , Kang Bei , Vasanth Jayaraman , Hari Krishnan Krishnamurthy
IPC: G01N33/543 , B01J19/00
CPC classification number: G01N33/54353 , B01J19/0046 , B01J2219/00432 , B01J2219/00509 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00711 , B01J2219/00725
Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, methods of attaching a biomolecule to an array using a photoactivated conjugation compound are disclosed. Methods of generating site-specific attachment of biomolecules to an array are also disclosed. Arrays generated by these methods and methods of using these arrays are also disclosed.
-
公开(公告)号：US11815512B2
公开(公告)日：2023-11-14
申请号：US16925224
申请日：2020-07-09
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/00326 , G01N2035/1034
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and methods of assuring a uniformly high quality of a microarray of features that are attached to a surface of the microarray at positionally-defined locations.
-
公开(公告)号：US20230294064A1
公开(公告)日：2023-09-21
申请号：US18106443
申请日：2023-02-06
Applicant: VIBRANT HOLDINGS, LLC
Inventor： John J. Rajasekaran
CPC classification number: B01J19/0046 , C12Q1/6837 , C40B50/14 , G03F7/0045 , G03F7/2004 , G03F7/42 , C40B50/00 , C12Q1/68 , B01J2219/00432 , B01J2219/00504 , B01J2219/00529 , B01J2219/00533 , B01J2219/00596 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00729 , G03F7/162
Abstract: Disclosed herein are formulations, substrates, and arrays for the synthesis of PNA chains and PNA-DNA chimera on microarrays. In some embodiments, the formulations include a photo-protective compound that shields any PNA monomers, PNA polymers, or PNA-DNA chimera already attached to a microarray from radiation exposure during the synthesis of the PNA or PNA-DNA chains. In some embodiments, substrates and arrays comprise a porous or a planar layer for synthesis and attachment of PNA or DNA monomers, or PNA or PNA-DNA polymers. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of PNA monomers or PNA polymers to a microarray substrate.
-
公开(公告)号：US11674956B2
公开(公告)日：2023-06-13
申请号：US17839160
申请日：2022-06-13
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/00326 , G01N2035/1034
Abstract: Disclosed herein are methods for collecting data from chip arrays and for piecewise real-time scanning and stitching of said data. Such arrays can comprise a plurality of microarrays, each microarray comprising biomolecular features that are attached to a surface of the microarray.
-
Patent Agency Ranking
公开(公告)号：US20210339247A1
公开(公告)日：2021-11-04
申请号：US17316111
申请日：2021-05-10
Applicant: Vibrant Holdings LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy , Karthik Krishna
IPC: B01L3/00 , G01N1/28 , G01N35/00 , G01N35/02 , C12Q1/6837
Abstract: Disclosed herein are methods, tools, pillar plates, and tool assemblies for biomolecular analysis using microarrays that reduces the likelihood of air bubbles being trapped by the microarrays. Embodiments of the tools include two clamps that have a tool mount portion and a grasping portion. The tool mount portion is configured to engage a lifting mechanism of a plate handling robot for moving a pillar plate that include microarrays. The grasping portion is configured to freely suspend the pillar plate at an inclination of a non-zero tilt angle relative to a plane normal to the tool mount portion. Embodiments of pillar plates include two protruding edges on opposite sides of the pillar plate and a plurality of pillars with one or more affixed microarrays. Embodiments of the tool assembly include the tool and the pillar plate, wherein the protruding edges are configured to engage with the grasping portions.
-
公开(公告)号：US20200095635A1
公开(公告)日：2020-03-26
申请号：US16709423
申请日：2019-12-10
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran
IPC: C12Q1/6876 , C12Q1/6837 , C12Q1/6874 , C40B30/04
Abstract: Disclosed herein are compositions, probes, devices, and processes useful for detecting specific reactions and binding interactions with biological molecules. In certain embodiments, methods of binding one or more biomolecules to a solid support are disclosed. Methods of generating site-specific sequences for one or more biomolecules from a solid support are also disclosed. Biological complexes generated by these methods are also disclosed.
-
公开(公告)号：US20170269077A1
公开(公告)日：2017-09-21
申请号：US15510223
申请日：2015-09-10
Applicant: VIBRANT HOLDINGS, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Kang Bei , Tianhao Wang , Karthik Krishna , Hari Krishnan Krishnamurthy
IPC: G01N33/564 , C07K7/08 , A61K38/10 , G01N33/68
CPC classification number: G01N33/564 , A61K38/10 , A61K39/00 , C07K7/08 , C40B40/10 , G01N33/6854 , G01N33/6878 , G01N2800/02 , G01N2800/24
Abstract: The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
-
公开(公告)号：US20160003816A1
公开(公告)日：2016-01-07
申请号：US14432200
申请日：2013-09-30
Applicant: VIBRANT HOLDINGS LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Bei Kang , Hari Krishnan Krishnamurthy
IPC: G01N33/543
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N2035/00158 , G01N2035/00168
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
-
公开(公告)号：US20150260712A1
公开(公告)日：2015-09-17
申请号：US14672123
申请日：2015-03-28
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Bei Kang , Hari Krishnan Krishnamurthy
IPC: G01N33/543
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N2035/00158 , G01N2035/00168
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
Abstract translation: 本文公开了制剂，底物和阵列。 本文还公开了制备和使用制剂，基底和阵列的方法。 还公开了用于鉴定可用于疾病的诊断和治疗的肽序列的方法，以及使用肽序列诊断和治疗疾病例如乳糜泻的方法。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。
-
-
-
-
-
-
-
-
-
Search Results
43
records
(took 0.03 seconds)
