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公开(公告)号：US11815512B2
公开(公告)日：2023-11-14
申请号：US16925224
申请日：2020-07-09
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/00326 , G01N2035/1034
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and methods of assuring a uniformly high quality of a microarray of features that are attached to a surface of the microarray at positionally-defined locations.
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公开(公告)号：US11674956B2
公开(公告)日：2023-06-13
申请号：US17839160
申请日：2022-06-13
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/00326 , G01N2035/1034
Abstract: Disclosed herein are methods for collecting data from chip arrays and for piecewise real-time scanning and stitching of said data. Such arrays can comprise a plurality of microarrays, each microarray comprising biomolecular features that are attached to a surface of the microarray.
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公开(公告)号：US20210339247A1
公开(公告)日：2021-11-04
申请号：US17316111
申请日：2021-05-10
Applicant: Vibrant Holdings LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy , Karthik Krishna
IPC: B01L3/00 , G01N1/28 , G01N35/00 , G01N35/02 , C12Q1/6837
Abstract: Disclosed herein are methods, tools, pillar plates, and tool assemblies for biomolecular analysis using microarrays that reduces the likelihood of air bubbles being trapped by the microarrays. Embodiments of the tools include two clamps that have a tool mount portion and a grasping portion. The tool mount portion is configured to engage a lifting mechanism of a plate handling robot for moving a pillar plate that include microarrays. The grasping portion is configured to freely suspend the pillar plate at an inclination of a non-zero tilt angle relative to a plane normal to the tool mount portion. Embodiments of pillar plates include two protruding edges on opposite sides of the pillar plate and a plurality of pillars with one or more affixed microarrays. Embodiments of the tool assembly include the tool and the pillar plate, wherein the protruding edges are configured to engage with the grasping portions.
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公开(公告)号：US20170269077A1
公开(公告)日：2017-09-21
申请号：US15510223
申请日：2015-09-10
Applicant: VIBRANT HOLDINGS, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Kang Bei , Tianhao Wang , Karthik Krishna , Hari Krishnan Krishnamurthy
IPC: G01N33/564 , C07K7/08 , A61K38/10 , G01N33/68
CPC classification number: G01N33/564 , A61K38/10 , A61K39/00 , C07K7/08 , C40B40/10 , G01N33/6854 , G01N33/6878 , G01N2800/02 , G01N2800/24
Abstract: The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
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公开(公告)号：US20240118273A1
公开(公告)日：2024-04-11
申请号：US18368931
申请日：2023-09-15
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC: G01N33/543 , C40B40/06 , C40B40/10 , G01N35/00 , G16B20/00
CPC classification number: G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/1034
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and methods of assuring a uniformly high quality of a microarray of features that are attached to a surface of the microarray at positionally-defined locations.
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Patent Agency Ranking
公开(公告)号：US20210380629A1
公开(公告)日：2021-12-09
申请号：US17054067
申请日：2019-05-09
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Anirudh Venugopal , Kang Bei , Tianhao Wang , Karthik Krishna , Hari Krishnan Krishnamurthy
Abstract: Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.
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公开(公告)号：US10286376B2
公开(公告)日：2019-05-14
申请号：US14442389
申请日：2013-11-14
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy , Punitha Vedantham
Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
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公开(公告)号：US10175234B2
公开(公告)日：2019-01-08
申请号：US15216267
申请日：2016-07-21
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC: C12Q1/68 , G01N33/543 , C40B40/10 , C40B40/06 , G01N35/00
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20170192007A1
公开(公告)日：2017-07-06
申请号：US14768196
申请日：2014-02-17
Applicant: VIBRANT HOLDINGS, LLC.
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20160067667A1
公开(公告)日：2016-03-10
申请号：US14941404
申请日：2015-11-13
Applicant: Vibrant Holdings, LLC
Inventor： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00432 , B01J2219/00596 , B01J2219/00621 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , C07K1/047 , C40B40/10 , C40B60/14 , G01N33/54353 , G01N2800/00
Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
Abstract translation: 本文公开了制剂，底物和阵列。 本文还公开了制备和使用制剂，基底和阵列的方法。 还公开了用于鉴定可用于疾病的诊断和治疗的肽序列的方法，以及使用肽序列诊断和治疗疾病例如乳糜泻的方法。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。
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