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公开(公告)号：US20240118273A1
公开(公告)日：2024-04-11
申请号：US18368931
申请日：2023-09-15
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： G01N33/543 , C40B40/06 , C40B40/10 , G01N35/00 , G16B20/00
CPC分类号： G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/1034
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and methods of assuring a uniformly high quality of a microarray of features that are attached to a surface of the microarray at positionally-defined locations.
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公开(公告)号：US20210380629A1
公开(公告)日：2021-12-09
申请号：US17054067
申请日：2019-05-09
发明人： John J. Rajasekaran , Vasanth Jayaraman , Anirudh Venugopal , Kang Bei , Tianhao Wang , Karthik Krishna , Hari Krishnan Krishnamurthy
摘要： Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.
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公开(公告)号：US10286376B2
公开(公告)日：2019-05-14
申请号：US14442389
申请日：2013-11-14
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy , Punitha Vedantham
摘要： Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
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公开(公告)号：US10175234B2
公开(公告)日：2019-01-08
申请号：US15216267
申请日：2016-07-21
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： C12Q1/68 , G01N33/543 , C40B40/10 , C40B40/06 , G01N35/00
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20170192007A1
公开(公告)日：2017-07-06
申请号：US14768196
申请日：2014-02-17
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20160067667A1
公开(公告)日：2016-03-10
申请号：US14941404
申请日：2015-11-13
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00596 , B01J2219/00621 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , C07K1/047 , C40B40/10 , C40B60/14 , G01N33/54353 , G01N2800/00
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
摘要翻译： 本文公开了制剂，底物和阵列。 本文还公开了制备和使用制剂，基底和阵列的方法。 还公开了用于鉴定可用于疾病的诊断和治疗的肽序列的方法，以及使用肽序列诊断和治疗疾病例如乳糜泻的方法。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。
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公开(公告)号：US20230294063A1
公开(公告)日：2023-09-21
申请号：US17933465
申请日：2022-09-19
申请人： Vibrant Holdings LLC
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： B01J19/00 , C07K1/04 , G01N33/543
CPC分类号： B01J19/0046 , C07K1/047 , G01N33/54353 , C40B40/10
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US11565231B2
公开(公告)日：2023-01-31
申请号：US16581730
申请日：2019-09-24
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： C40B40/10 , B01J19/00 , C07K1/04 , G01N33/543 , C40B60/14
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20220365080A1
公开(公告)日：2022-11-17
申请号：US17839160
申请日：2022-06-13
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： G01N33/543 , G01N35/00 , C40B40/10 , C40B40/06 , G16B20/00
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：US20220162698A1
公开(公告)日：2022-05-26
申请号：US17492189
申请日：2021-10-01
申请人： Vibrant Holdings LLC
发明人： John J. Rajasekaran
IPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q1/6874 , C40B30/04
摘要： Disclosed herein are compositions, probes, devices, and processes useful for detecting specific reactions and binding interactions with biological molecules. In certain embodiments, methods of binding one or more biomolecules to a solid support are disclosed. Methods of generating site-specific sequences for one or more biomolecules from a solid support are also disclosed. Biological complexes generated by these methods are also disclosed.
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