公开(公告)号：US20240317671A1

公开(公告)日：2024-09-26

申请号：US18731457

申请日：2024-06-03

申请人： Buck Institute for Research on Aging

发明人： Scott Michael ULRICH

IPC分类号： C07C69/675 ,  A61P3/04 ,  C12N9/20 ,  C12N11/06 ,  C12N11/087 ,  C12P7/42 ,  C12P7/52 ,  C12P7/62 ,  C12P41/00

CPC分类号： C07C69/675 ,  A61P3/04 ,  C12N9/20 ,  C12P7/42 ,  C12P7/52 ,  C12P7/62 ,  C12P41/003 ,  C12N11/06 ,  C12N11/087

摘要： In various embodiments methods of preparing hydroxybutyryl 3-hydroxybutyrate and related compounds are provided along with methods of use thereof.

公开(公告)号：US12070543B2

公开(公告)日：2024-08-27

申请号：US18323055

申请日：2023-05-24

申请人： Orth Consulting, LLC

发明人： Donald S. Orth ,  Roger W. Orth

IPC分类号： A61M1/36 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/14 ,  A61M1/16 ,  A61M1/26 ,  A61M1/34 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/08 ,  B01J20/22 ,  B01J31/00 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00

CPC分类号： A61M1/3687 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/15632 ,  A61M1/1621 ,  A61M1/267 ,  A61M1/3489 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3679 ,  A61M1/3689 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/043 ,  B01D69/08 ,  B01J20/22 ,  B01J31/003 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00 ,  A61M2202/0445 ,  A61M2202/0456 ,  A61M2202/046 ,  A61M2202/07 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3303 ,  B01J2220/4812 ,  B01J2220/4868

摘要： A detoxification method for treating sepsis, microbial infections, and other inflammatory conditions includes the steps of inducing flow of patient blood through a blood treatment device consisting of a bioreactor inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) and extracellular adenosine triphosphate (ATP) contained within patient blood can be irreversibly detoxified by passage of patient blood over a bioreactor surface having attached or immobilized alkaline phosphatase enzymes and acyloxyacyl hydrolase enzyme, with the bioreactor being contained within the blood treatment device. The method uses continuous treatment of a patient's blood to convert LPS and extracellular ATP in blood into inhibitors of inflammation in vivo without adding any chemicals to the bloodstream of the patient.

公开(公告)号：US20240254436A1

公开(公告)日：2024-08-01

申请号：US18426809

申请日：2024-01-30

申请人： Alma Mater Studiorum - Università di Bologna

发明人： Stefania RAPINO ,  Francesco ZERBETTO ,  Gastone CASTELLANI ,  Stefano SALVIOLI ,  Beatrice FRABONI ,  Isabella ZIRONI ,  Maria CONTE ,  Claudio FRANCESCHI ,  Daniela SALVATORE ,  Maila BECCONI

IPC分类号： C12N5/00 ,  C12N5/09 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/08 ,  C12N11/04 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089 ,  C12N11/12 ,  G01N33/50

CPC分类号： C12N5/0018 ,  C12N5/0068 ,  C12N5/0693 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0036 ,  C12N9/0053 ,  C12N9/0061 ,  C12N9/0065 ,  C12N9/0069 ,  C12N9/0093 ,  C12N11/04 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089 ,  C12N11/12 ,  C12Y101/03004 ,  C12Y106/03001 ,  C12Y109/03001 ,  C12Y110/03002 ,  C12Y111/01006 ,  C12Y113/12004 ,  C12Y117/03002 ,  G01N33/5008 ,  C12N2500/02 ,  C12N2501/71 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2533/76 ,  C12N2533/78 ,  C12N2533/80 ,  C12N2537/10

摘要： The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.

公开(公告)号：US11911357B2

公开(公告)日：2024-02-27

申请号：US17332194

申请日：2021-05-27

申请人： Alcresta Therapeutics, Inc.

发明人： Robert Gallotto ,  Greta L. Loring ,  Kenneth Gary ,  Edward S. Park ,  David J. Brown ,  Willem Robert Klaas Schoevaart ,  Michiel Christian Alexander van Vliet

IPC分类号： A23L33/00 ,  C12N9/20 ,  A61K31/202 ,  A61L29/04 ,  A61M5/14 ,  A61M5/142 ,  C12N11/06 ,  A61J15/00 ,  A23L33/12 ,  C12N11/087 ,  C12N11/089

CPC分类号： A61K31/202 ,  A23L33/00 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0076 ,  A61L29/048 ,  A61M5/14 ,  A61M5/142 ,  A61M5/1413 ,  C12N9/20 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089

摘要： Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：US11905548B2

公开(公告)日：2024-02-20

申请号：US17881175

申请日：2022-08-04

申请人： Waters Technologies Corporation

发明人： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

IPC分类号： C12Q1/37 ,  C12N11/06 ,  C12N11/14 ,  C12M1/40 ,  C12M1/34 ,  C12Q1/48

CPC分类号： C12Q1/37 ,  C12M21/18 ,  C12M41/40 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/48

摘要： An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

公开(公告)号：US20230340296A1

公开(公告)日：2023-10-26

申请号：US18070870

申请日：2022-11-29

申请人： Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

发明人： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC分类号： C09D189/00 ,  C12N9/14 ,  C12N9/20 ,  C09D7/40 ,  C09D5/16 ,  C12N11/06 ,  C12N9/54 ,  C12N9/96 ,  C12N9/26 ,  C08G65/333 ,  C09D5/02 ,  A61K47/60 ,  C12N11/089 ,  C09D175/16

CPC分类号： C09D189/00 ,  A61K47/60 ,  C08G65/33337 ,  C09D5/024 ,  C09D5/16 ,  C09D7/40 ,  C09D175/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/2408 ,  C12N9/2411 ,  C12N9/54 ,  C12N9/96 ,  C12N11/06 ,  C12N11/089 ,  C08L2203/02 ,  C08L2205/02

摘要： Bioactive coatings are provided with two component solvent borne resin and an enzyme dispersed therein. The unique coatings provide for enzyme dispersion in the two component solvent borne resin in aggregates with small particle sizes of up to 5 micrometers. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

公开(公告)号：US20230212426A1

公开(公告)日：2023-07-06

申请号：US18069508

申请日：2022-12-21

申请人： Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

发明人： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC分类号： C09D189/00 ,  C09D5/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/26 ,  C12N9/54 ,  C12N9/96 ,  C08G65/333 ,  C09D5/02 ,  A61K47/60 ,  C09D7/40 ,  C12N11/089 ,  C12N11/06 ,  C09D175/16

CPC分类号： C09D189/00 ,  C09D5/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/2411 ,  C12N9/54 ,  C12N9/96 ,  C12N9/2408 ,  C08G65/33337 ,  C09D5/024 ,  A61K47/60 ,  C09D7/40 ,  C12N11/089 ,  C12N11/06 ,  C09D175/16 ,  C08L2203/02 ,  C08L2205/02

摘要： A process of stabilizing the activity of an enzyme against inactivation by water weathering are provided including associating one or more polymeric moieties of a polyoxyethylene having a molecular weight of 10,000 Daltons or greater with an enzyme to form a chemically modified enzyme; and dispersing said chemically modified enzyme in a base to form a water-stabilized active coating material.

公开(公告)号：US11597853B2

公开(公告)日：2023-03-07

申请号：US16258564

申请日：2019-01-26

申请人： Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

发明人： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC分类号： C12N11/08 ,  C09D5/16 ,  C12N11/06 ,  C09D5/02 ,  C09D189/00 ,  C12N9/14 ,  C12N9/20 ,  C12N9/26 ,  C12N9/54 ,  C12N9/56 ,  C08G65/333 ,  A61K47/60 ,  C09D7/40 ,  C09D175/16 ,  C12N9/96 ,  C12N11/089

摘要： Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

公开(公告)号：US11542410B2

公开(公告)日：2023-01-03

申请号：US16724682

申请日：2019-12-23

申请人： Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

发明人： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC分类号： C12N9/14 ,  C12N9/20 ,  C12N9/54 ,  C12N9/96 ,  C12N11/06 ,  C09D189/00 ,  C09D5/16 ,  C12N9/26 ,  C08G65/333 ,  C09D5/02 ,  A61K47/60 ,  C09D7/40 ,  C12N11/089 ,  C09D175/16

摘要： Bioactive coatings that are stabilized against inactivation by weathering are provided including a base including an enzyme associated therein, and a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

公开(公告)号：US20220348976A1

公开(公告)日：2022-11-03

申请号：US17838852

申请日：2022-06-13

申请人： CureVac AG

发明人： Tilmann ROOS ,  Benyamin YAZDAN PANAH ,  Markus CONZELMANN ,  Veronika WAGNER

IPC分类号： C12P19/34 ,  C12N9/12 ,  C12N11/06 ,  C12N11/14 ,  C12N11/02 ,  C12N15/10 ,  C12N15/113 ,  C12Q1/6806

摘要： The present invention relates to an immobilized poly(N)polymerase (PNP), methods of producing said PNP and uses thereof. Further disclosed is an enzyme reactor and kit comprising the PNP for producing polynucleotidylated ribonucleic acid (poly(N)RNA) molecules which are useful in gene therapy, immunotherapy, protein replacement therapy and/or vaccination.