公开(公告)号：US11478431B2

公开(公告)日：2022-10-25

申请号：US16902877

申请日：2020-06-16

申请人： Alcresta Therapeutics, Inc.

发明人： Eric First ,  David Widom

IPC分类号： A61K9/48 ,  A61K9/50 ,  A61K9/24 ,  A61M31/00 ,  A61K45/06 ,  A61J3/07 ,  A61J7/00 ,  A61K31/12 ,  A61J1/20 ,  A61K31/05 ,  A61K31/122 ,  A61K36/9066 ,  A61K31/202 ,  A23L33/115 ,  A61K31/4045 ,  A23L33/12 ,  A61K31/198 ,  A61K33/06

摘要： Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

公开(公告)号：US11045440B2

公开(公告)日：2021-06-29

申请号：US16287543

申请日：2019-02-27

申请人： Alcresta Therapeutics, Inc.

发明人： Robert Gallotto ,  Greta L. Loring ,  Kenneth Gary ,  Edward S. Park ,  David J. Brown ,  Willem Robert Klaas Schoevaart ,  Michiel Christian Alexander van Vliet

IPC分类号： A61K31/202 ,  C12N11/02 ,  A61L29/04 ,  A61M5/14 ,  A61M5/142 ,  C12N11/06 ,  C12N11/08 ,  A61J15/00 ,  A23L33/00 ,  A23L33/12 ,  C12N9/20

摘要： Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：US20200306196A1

公开(公告)日：2020-10-01

申请号：US16902877

申请日：2020-06-16

申请人： Alcresta Therapeutics, Inc.

发明人： Eric First ,  David Widom

IPC分类号： A61K9/48 ,  A61K9/50 ,  A61K9/24 ,  A61M31/00 ,  A61K45/06 ,  A61J3/07 ,  A61J7/00 ,  A61K31/12 ,  A61J1/20 ,  A61K31/05 ,  A61K31/122 ,  A61K36/9066 ,  A61K31/202 ,  A23L33/115 ,  A61K31/4045 ,  A23L33/12 ,  A61K31/198 ,  A61K33/06

摘要： Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

公开(公告)号：US09775783B2

公开(公告)日：2017-10-03

申请号：US15587513

申请日：2017-05-05

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC分类号： A01N1/00 ,  C12M3/00 ,  A61J15/00 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  B65D85/72 ,  B65D81/32 ,  B65D41/02 ,  B65D1/02 ,  A61K38/46 ,  A61K31/202 ,  A23K20/158 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A23K50/30

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20240350369A1

公开(公告)日：2024-10-24

申请号：US18756522

申请日：2024-06-27

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. MARGOLIN ,  Robert GALLOTTO ,  Bhami SHENOY

IPC分类号： A61J15/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US11998511B2

公开(公告)日：2024-06-04

申请号：US17853168

申请日：2022-06-29

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC分类号： C12M1/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61J15/00 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20240065943A1

公开(公告)日：2024-02-29

申请号：US18502995

申请日：2023-11-06

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. MARGOLIN ,  Robert GALLOTTO ,  Bhami SHENOY

IPC分类号： A61J15/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monogiycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US11872191B2

公开(公告)日：2024-01-16

申请号：US17211487

申请日：2021-03-24

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC分类号： B65D1/02 ,  A61K38/00 ,  A61J15/00 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A61K31/202 ,  A61K38/46 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  A23K50/30

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20220331208A1

公开(公告)日：2022-10-20

申请号：US17853168

申请日：2022-06-29

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. MARGOLIN ,  Robert GALLOTTO ,  Bhami SHENOY

IPC分类号： A61J15/00 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  A23K50/30

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20210259924A1

公开(公告)日：2021-08-26

申请号：US17317374

申请日：2021-05-11

申请人： Alcresta Therapeutics, Inc.

发明人： Eric FIRST ,  David Widom

IPC分类号： A61J9/00 ,  A61J1/20 ,  A23L33/115 ,  A61J15/00

摘要： Exemplary embodiments of the disclosure may be drawn to a device having a vessel configured to contain a source of lipids and a chamber fluidly connected to an outlet of the vessel. The chamber may contain immobilized lipase positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber. The device may also include an outlet through which the lipids flow after passing through the chamber.