公开(公告)号：US11998511B2

公开(公告)日：2024-06-04

申请号：US17853168

申请日：2022-06-29

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: C12M1/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61J15/00 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

CPC classification number: A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US11872191B2

公开(公告)日：2024-01-16

申请号：US17211487

申请日：2021-03-24

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: B65D1/02 ,  A61K38/00 ,  A61J15/00 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A61K31/202 ,  A61K38/46 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  A23K50/30

CPC classification number: A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US12138226B2

公开(公告)日：2024-11-12

申请号：US17853159

申请日：2022-06-29

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A23L33/00 ,  A23D7/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/115 ,  A23L33/12 ,  A61J15/00 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US11045440B2

公开(公告)日：2021-06-29

申请号：US16287543

申请日：2019-02-27

Applicant: Alcresta Therapeutics, Inc.

Inventor： Robert Gallotto ,  Greta L. Loring ,  Kenneth Gary ,  Edward S. Park ,  David J. Brown ,  Willem Robert Klaas Schoevaart ,  Michiel Christian Alexander van Vliet

IPC: A61K31/202 ,  C12N11/02 ,  A61L29/04 ,  A61M5/14 ,  A61M5/142 ,  C12N11/06 ,  C12N11/08 ,  A61J15/00 ,  A23L33/00 ,  A23L33/12 ,  C12N9/20

Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：US09775783B2

公开(公告)日：2017-10-03

申请号：US15587513

申请日：2017-05-05

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A01N1/00 ,  C12M3/00 ,  A61J15/00 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  B65D85/72 ,  B65D81/32 ,  B65D41/02 ,  B65D1/02 ,  A61K38/46 ,  A61K31/202 ,  A23K20/158 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A23K50/30

CPC classification number: A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  C12Y301/01

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US12178784B2

公开(公告)日：2024-12-31

申请号：US17853159

申请日：2022-06-29

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A23L33/00 ,  A23D7/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/115 ,  A23L33/12 ,  A61J15/00 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20210212904A1

公开(公告)日：2021-07-15

申请号：US17211487

申请日：2021-03-24

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A61J15/00 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  A23K50/30

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monogiycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US10258590B2

公开(公告)日：2019-04-16

申请号：US15291530

申请日：2016-10-12

Applicant: ALCRESTA THERAPEUTICS, INC.

Inventor： Robert Gallotto ,  Greta L. Loring ,  Kenneth Gary ,  Edward S. Park ,  David J. Brown ,  Willem Robert Klaas Schoevaart ,  Michiel Christian Alexander van Vliet

IPC: C12M3/00 ,  C12N11/00 ,  B01L3/00 ,  A61K31/202 ,  A61L29/04 ,  A61M5/14 ,  A61M5/142 ,  C12N11/06 ,  C12N11/08 ,  A61J15/00 ,  A23L33/00 ,  A23L33/12 ,  C12N9/20

Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：US09687420B2

公开(公告)日：2017-06-27

申请号：US15240596

申请日：2016-08-18

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A61K9/00 ,  A61J15/00 ,  A23D7/01 ,  A23D9/013 ,  A61K31/202 ,  A61K38/46 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  A23K20/158 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A23K50/30

CPC classification number: A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  C12Y301/01

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US12059391B2

公开(公告)日：2024-08-13

申请号：US17852928

申请日：2022-06-29

Applicant: Alcresta Therapeutics, Inc.

Inventor： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC: A23L33/00 ,  A23D7/01 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/00 ,  A23L33/115 ,  A23L33/12 ,  A61J15/00 ,  A61K9/00 ,  A61K31/202 ,  A61K38/46 ,  B01L3/00 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72

CPC classification number: A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  A23V2002/00 ,  C12Y301/01

Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.