公开(公告)号：US20230296627A1

公开(公告)日：2023-09-21

申请号：US17971081

申请日：2022-10-21

申请人： CORNELL UNIVERSITY

发明人： Alexander J.A. TRAVIS ,  Roy COHEN

IPC分类号： G01N33/68 ,  C12Q1/25 ,  C12Q1/32 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/66 ,  C12N11/18

CPC分类号： G01N33/6896 ,  C12Q1/25 ,  C12Q1/32 ,  C12Q1/42 ,  C12Q1/485 ,  C12Q1/66 ,  C12N11/18 ,  G01N2800/2871 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/2857

摘要： The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.

公开(公告)号：US11512305B2

公开(公告)日：2022-11-29

申请号：US15840283

申请日：2017-12-13

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Igor L. Medintz ,  James N. Vranish ,  Mario Ancona ,  Kimihiro Susumu ,  Sebastian A. Diaz

IPC分类号： C12N11/18 ,  C12N9/12 ,  C12N9/04 ,  C12N9/88 ,  C12N9/92 ,  C12N9/02 ,  C12N9/90 ,  C12P9/00

摘要： A nanoparticle (for example, quantum dot) serves as a substrate for immobilizing enzymes involved in consecutive reactions as a cascade. This results in a significant increase in the rate of catalysis as well as final product yield compared to non-immobilized enzymes.

公开(公告)号：US20220290126A1

公开(公告)日：2022-09-15

申请号：US17829768

申请日：2022-06-01

申请人： The Board of Regents of The University of Texas System

发明人： Sanjay Awasthi

IPC分类号： C12N15/10 ,  C12N11/18 ,  C12N15/11 ,  C12N5/09 ,  C07K16/40 ,  C12N15/113 ,  A61P35/00

摘要： Partial depletion of RLIP76 in p53 deficient living subject has shown many health benefits. In one embodiment, partical Rlip depletion is used to prevent or treat cancer in p53 deficient living subjects. In another embodiment, partial Rlip depletion is used for reversion of DNA-methylation abnormalities caused by the lack of p53 to normal in p53 deficient living subjects. In yet another embodiment, partial Rlip depletion is used in reduction of blood glucose, insulin-resistance, hyperlipidemina, or any combination thereof in p53 deficient living subjects. Methods of using liposome containing anti-sense nucleic acid or double stranded siRNA to partially deplete RLIP76 and thus treat p53 deficient subject are disclosed. The approaches described herein can be especially helpful in preventing cancer in Li-Fraumeni patients.

公开(公告)号：US10881102B2

公开(公告)日：2021-01-05

申请号：US15572306

申请日：2016-05-09

申请人： ZYMtronix, LLC

发明人： Stephane Corgie

IPC分类号： A01N25/14 ,  C12N11/18 ,  C12N9/00 ,  C12N11/14 ,  A01N59/00 ,  A61P31/12 ,  A61P31/04 ,  B82Y5/00

摘要： The present invention provides compositions and methods for reducing microbial contamination or infection in plants, animals, fabrics, and products therefrom. The present invention also provides compositions and methods for reducing human infections. In particular, it provides solid magnetic nanoparticles comprising bacteriostatic, bactericidal, fungistatic, or fungicidal enzymes in one component, and substrates for the enzymes in another component. The compositions are dormant and become active upon exposure to hydration and oxygen.

公开(公告)号：US20200255881A1

公开(公告)日：2020-08-13

申请号：US16752222

申请日：2020-01-24

申请人： Lawrence Livermore National Security, LLC

发明人： Nicholas N. Watkins ,  Neil Reginald Beer ,  Kenneth W. Turteltaub

IPC分类号： C12P21/02 ,  B01D15/38 ,  C12N11/18

摘要： Provided herein are cell free protein synthesis (CFPS) systems comprising a plurality of ribosomes attached to or encapsulated within a structure, or a plurality of structures, and, optionally, a solid support. Also provided are related kits and uses of the CFPS systems. Methods of producing a protein and methods of treating a disease are provided herein.

公开(公告)号：US08535924B2

公开(公告)日：2013-09-17

申请号：US13288680

申请日：2011-11-03

申请人： Douglas A. Dale ,  Thomas S. Green

发明人： Douglas A. Dale ,  Thomas S. Green

IPC分类号： C12N9/98 ,  C12N11/18 ,  C12N11/14 ,  C12N11/02 ,  C12N11/08 ,  C12N11/04 ,  D06M16/00 ,  C11D7/42 ,  C11D3/386

CPC分类号： C11D17/0039 ,  C11D3/38672 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57449 ,  G01N33/6872 ,  Y10T428/2991 ,  Y10T428/2998

摘要： A granule with an allergenic component has reduced dust by including antifoam added during the production of the granule. The antifoam may be dispersed throughout the granule or added to one of the components of the granule. The granule with antifoam produces at least 30% less dust than a comparable granule produced according to a process in which no antifoam is added.

摘要翻译： 具有过敏成分的颗粒通过在颗粒生产期间加入消泡剂来减少粉尘。 消泡剂可以分散在整个颗粒中或加入到颗粒的一种组分中。 具有消泡剂的颗粒与根据不加入消泡剂的方法制备的相当的颗粒相比，产生的灰尘少至少30％。

公开(公告)号：US08252570B2

公开(公告)日：2012-08-28

申请号：US11900773

申请日：2007-09-12

申请人： Ed Harlow ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Lowell L. Wood, Jr.

发明人： Ed Harlow ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Lowell L. Wood, Jr.

IPC分类号： C12N11/18 ,  A61K9/48 ,  C12N9/00

CPC分类号： A61F2/00 ,  A61K9/0024 ,  A61K47/6901 ,  A61K2035/126 ,  A61L27/3608 ,  A61L27/3808 ,  B33Y80/00 ,  C12N5/0654 ,  C12N2510/00

摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.

公开(公告)号：US20110262963A1

公开(公告)日：2011-10-27

申请号：US13125547

申请日：2009-10-23

申请人： Bernhard Geierstanger ,  Weijia Ou ,  Susan E. Cellitti ,  Tetsuo Uno ,  Tiffany Crossgrove ,  Hsien-Po Chiu ,  Jan Grunewald ,  Xueshi Hao

发明人： Bernhard Geierstanger ,  Weijia Ou ,  Susan E. Cellitti ,  Tetsuo Uno ,  Tiffany Crossgrove ,  Hsien-Po Chiu ,  Jan Grunewald ,  Xueshi Hao

IPC分类号： C12P21/02 ,  C07D207/22 ,  C07K16/00 ,  C12P21/08 ,  C07K14/485 ,  C12N11/18 ,  C12N9/90 ,  C07K14/50 ,  C07K14/525 ,  C07K14/435 ,  C07K14/505

CPC分类号： C12P21/00 ,  C07D207/20 ,  C07D207/48 ,  C07K5/0215

摘要： Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.

摘要翻译： 本文公开的是吡咯啉 - 羧基赖氨酸（PCL），吡咯赖氨酸类似物，其是天然的，生物合成产生的氨基酸，以及用于生物合成生成PCL的方法。 本文还公开了具有并入其中的PCL的蛋白质，多肽和肽以及将PCL并入此类蛋白质，多肽和肽的方法。 本文还公开了具有并入其中的PCL或吡咯赖胺的蛋白质，多肽和肽的位点特异性衍生化。 本文还公开了具有并入其中的PCL或吡咯赖氨酸的蛋白质，多肽和肽的交联。

公开(公告)号：US20110059373A1

公开(公告)日：2011-03-10

申请号：US12738367

申请日：2008-10-16

申请人： Alexander Travis

发明人： Alexander Travis

IPC分类号： H01M8/16 ,  C12N11/00 ,  C12N11/18 ,  C12M1/40 ,  C12P19/32

CPC分类号： C12P19/32

摘要： The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system.

摘要翻译： 本发明涉及一种生产ATP的系统。 该系统由支持物和与该载体偶联的一种或多种酶组成，其能够共同地从葡萄糖或果糖代谢产生ATP。 本发明还涉及包括该系统的装置以及涉及使用该系统进行涉及ATP转化成ADP的反应的方法。

公开(公告)号：US20050201973A1

公开(公告)日：2005-09-15

申请号：US10997679

申请日：2004-11-09

申请人： Jorma Virtanen ,  Sinikka Virtanen

发明人： Jorma Virtanen ,  Sinikka Virtanen

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K38/00 ,  A61K38/43 ,  A61K38/46 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61K48/00 ,  A61P9/10 ,  A61P31/12 ,  A61P43/00 ,  C07K14/73 ,  C07K16/10 ,  C07K19/00 ,  C12N11/18 ,  C12N15/88 ,  C12Q1/68 ,  G01N33/535 ,  A61K38/17 ,  A61K31/785 ,  C08G63/91

CPC分类号： A61K9/1271 ,  A61K38/00 ,  A61K47/56 ,  A61K47/68 ,  A61K47/6807 ,  A61K47/6839 ,  A61K47/6911 ,  C07K16/1063 ,  C07K19/00 ,  C07K2319/00 ,  C12N15/88 ,  C12Q1/68 ,  G01N33/535 ,  Y10S530/812 ,  Y10S977/907

摘要： A therapeutic supramolecule including a first component having a binding effector molecule such as a protein, a polypeptide, a lipid, or a sugar; and a second component including a therapeutic effector molecule such as a protein, a polypeptide, a lipid, or a sugar, where the binding effector molecule and therapeutic effector molecule are linked by a joining molecule, a peptide, or a dendrimer.

摘要翻译： 一种治疗性超分子，其包括具有结合效应分子如蛋白质，多肽，脂质或糖的第一成分; 以及包含治疗效应分子例如蛋白质，多肽，脂质或糖的第二组分，其中结合效应子分子和治疗效应分子通过连接分子，肽或树枝状大分子连接。