公开(公告)号：US09915601B2

公开(公告)日：2018-03-13

申请号：US14423134

申请日：2013-08-23

申请人： SATAKE CORPORATION

发明人： Akiko Nakata ,  Shinya Fushida ,  Akira Eto ,  Masanori Matsuda ,  Yukio Hosaka

IPC分类号： G01N1/00 ,  G01N15/00 ,  G01N21/00 ,  G01N15/14 ,  C12M1/34 ,  C12Q1/06 ,  G01N21/64

CPC分类号： G01N15/1456 ,  C12M41/36 ,  C12Q1/06 ,  G01N21/645 ,  G01N2015/0065 ,  G01N2015/035 ,  G01N2015/1486 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/12

摘要： An examination apparatus 1 for microorganisms for measuring an amount of microorganisms in a sample solution, the apparatus including stirring and mixing means 7 for stirring and mixing the sample solution into which a sample and a fluorescent staining reagent are added, in a sample container 5 formed of a material allowing light to pass through, an excitation light source 10 including a light source that irradiates an irradiation target surface of the sample container 5 with excitation light while the sample solution is being stirred by the stirring and mixing means 7, light receiving means 14 for detecting light and converting the light resulting from a fluorescent emission caused by excitation light from the excitation light source 10, into an electric signal, and control means 23 for detecting the number of emissions based on the electric signal from the light receiving means 14 and calculating the amount of the microorganisms contained in the sample in the sample container 5 based on the number of emissions.

公开(公告)号：US20180180523A1

公开(公告)日：2018-06-28

申请号：US15759280

申请日：2016-09-16

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人： Ines FRESE

IPC分类号： G01N15/02

CPC分类号： G01N15/0205 ,  G01N2015/0038 ,  G01N2015/035 ,  G01N2015/0693 ,  G01N2015/1087

摘要： The invention relates to a method for determining the average radius of gyration (rg) of particles with a size of ≤1 μm in a suspension, and to a device for carrying out the method according to the invention. The method is based on the scattering of linearly polarised electromagnetic radiation on nanoparticles, which, suspended in a solution, are moved through a through-flow cell. The irradiation is carried out perpendicular to the movement direction, wherein the scattering intensity is measured via at least four detectors that are arranged in a defined plane at defined angles. Alternatively, at least one mirror can be used in the position of at least one of the detectors, which deflects the radiation to at least one detector. Based on the scattering intensities, both the average radius of gyration (rg) of the particles as well as the concentration thereof in the suspension can be determined.

公开(公告)号：US20160077218A1

公开(公告)日：2016-03-17

申请号：US14748961

申请日：2015-06-24

申请人： STMICROELECTRONICS S.r.I.

发明人： Sara LOI ,  Alberto PAGANI

IPC分类号： G01T1/178 ,  G01T1/29 ,  G01T1/24

CPC分类号： G01T1/178 ,  F04B19/06 ,  F04B37/00 ,  G01N15/02 ,  G01N15/0205 ,  G01N15/06 ,  G01N15/10 ,  G01N2001/2276 ,  G01N2015/035 ,  G01T1/244 ,  G01T1/2928

摘要： A detection device is formed in a body of semiconductor material having a first face, a second face, and a cavity. A detection area formed in the cavity, and a gas pump is integrated in the body and configured to force movement of gas towards the detection area. A detection system of an optical type or a detector of alpha particles is arranged at least in part in the detection area.

摘要翻译： 检测装置形成在具有第一面，第二面和空腔的半导体材料的主体中。 形成在空腔中的检测区域和气体泵集成在主体中并且构造成迫使气体朝向检测区域移动。 光学类型的检测系统或α粒子的检测器至少部分地布置在检测区域中。

公开(公告)号：US11747257B2

公开(公告)日：2023-09-05

申请号：US17355430

申请日：2021-06-23

申请人： Malvern Panalytical Limited

发明人： Jason Corbett

IPC分类号： G01N15/02 ,  G01N15/00

CPC分类号： G01N15/0211 ,  G01N2015/0222 ,  G01N2015/035

摘要： An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.

公开(公告)号：US20190072476A1

公开(公告)日：2019-03-07

申请号：US15842889

申请日：2017-12-15

申请人： Industrial Technology Research Institute

发明人： Wei-Lan Chiu ,  Hsiang-Hung Chang

IPC分类号： G01N15/14

CPC分类号： G01N15/1434 ,  G01N15/0211 ,  G01N15/1404 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/0046 ,  G01N2015/035 ,  G01N2015/1447 ,  G01N2015/1486

摘要： An optical micro-particle detector including a light source, a gas channel and a plurality of optical detectors is provided. The light source is configured to generate a light beam. The gas channel has at least one curved segment. The curved segment has a light entrance and a plurality of light exits. The light beam from the light source enters the gas channel through the light entrance. The plurality of optical detectors are optically coupled to the light exits, respectively.

公开(公告)号：US20180013971A1

公开(公告)日：2018-01-11

申请号：US15637086

申请日：2017-06-29

申请人： OLYMPUS CORPORATION

发明人： Hideaki MATSUOTO ,  Osamu NONAKA

IPC分类号： H04N5/374 ,  H04N3/14

CPC分类号： H04N5/3741 ,  G01N2015/035 ,  G06K9/20 ,  G06K9/209 ,  H04N3/1587 ,  H04N3/1593 ,  H04N5/247

摘要： An observation system includes: a plurality of imaging sections to image one or more samples; a plurality of driving mechanisms that respectively move the imaging sections to change an imaging position for the samples; and a control circuit that controls operations of the driving mechanisms and the imaging sections to cause the imaging sections to image the samples, while causing the driving mechanisms to respectively move the imaging sections. The control circuit imposes different limitations on movement patterns of the imaging sections depending on a characteristic of the samples.

公开(公告)号：US20120162644A1

公开(公告)日：2012-06-28

申请号：US13336486

申请日：2011-12-23

申请人： Joonhyung KWON ,  Du Seop Yoon ,  Hee Yuel Roh ,  Soo Hyun Kim ,  Sung Yoon Ryu ,  Won Sik Kwon ,  Hyub Lee

发明人： Joonhyung KWON ,  Du Seop Yoon ,  Hee Yuel Roh ,  Soo Hyun Kim ,  Sung Yoon Ryu ,  Won Sik Kwon ,  Hyub Lee

IPC分类号： G01N21/47

CPC分类号： G01N15/06 ,  G01N21/21 ,  G01N21/53 ,  G01N21/64 ,  G01N2015/035 ,  G01N2015/0693

摘要： A microparticle detection apparatus is provided. The microparticle detection apparatus includes a light emitting optical element, a converging optical system disposed in an advancing direction of light emitted from the optical element to converge the light, a particle path located in an advancing direction of the light having passed through the converging optical system so that the particle path intersects the light, a beam blocking unit to block direct light having passed through the particle path, a condensing lens disposed at the rear of the beam blocking unit, and a detector disposed at the rear of the condensing lens to detect light scattered by particles. A focal point of light formed by the optical element and the converging optical system may be located at the rear of the particle path. A focal point of light irradiated to the particles may be different from the introduction position of the particles.

摘要翻译： 提供了微粒检测装置。 微粒检测装置包括发光光学元件，会聚光学系统，其沿着从光学元件发射的光的行进方向配置以会聚光，位于沿着通过会聚光学系统的光的前进方向上的粒子路径 使得粒子路径与光相交，光束阻挡单元阻止通过粒子路径的直接光，设置在光束阻挡单元的后部的聚光透镜和设置在聚光透镜后部的检测器 微粒散射光。 由光学元件和会聚光学系统形成的光的焦点可以位于粒子路径的后部。 照射到颗粒的光的焦点可以不同于颗粒的引入位置。

公开(公告)号：US20240210296A1

公开(公告)日：2024-06-27

申请号：US18573961

申请日：2022-06-24

申请人： ams-OSRAM AG

发明人： Jochen KRAFT ,  Jaka PRIBOSEK ,  Andreas TORTSCHANOFF

IPC分类号： G01N15/0205 ,  G01N15/00 ,  G01N15/075 ,  G02B6/12

CPC分类号： G01N15/0205 ,  G01N15/075 ,  G02B6/12 ,  G01N2015/035 ,  G02B2006/1215

摘要： A particulate matter detector includes a light emitter configured to emit light, a first, a second and a third waveguide, a waveguide splitter, a detector, and a controller. The third waveguide is free of cladding. The first waveguide is coupled to the light emitter and guides emitted light toward the waveguide splitter. The first waveguide includes an interrogation region formed by a cladding-free surface of the first waveguide. During a measurement phase, a first intensity of the light in the first waveguide is set for determining a change in the intensity of the light detected by the detector. An indication of an opacity of the surface of the first waveguide with accumulated particulate matter is output. During a cleaning phase, a second intensity of the light in the first waveguide is set for directing the accumulated particulate matter from the interrogation region to the third waveguide via optical forces.

公开(公告)号：US20170167981A1

公开(公告)日：2017-06-15

申请号：US14965948

申请日：2015-12-11

申请人： International Business Machines Corporation

发明人： Huan Hu ,  Oki Gunawan ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt ,  Yann Astier

IPC分类号： G01N21/64 ,  B01L3/00 ,  G01N15/14

CPC分类号： G01N21/6486 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2400/086 ,  G01N15/0255 ,  G01N15/1429 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/05 ,  G01N21/645 ,  G01N2015/0038 ,  G01N2015/0065 ,  G01N2015/035 ,  G01N2015/1081 ,  G01N2021/0346 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

摘要： Methods, apparatuses, and computer program products are provided where fluid, such as a blood sample, is entered into a microfluidic channel in a microchip where the microfluidic channel possesses a micro/nanopillar array for sorting molecules by size. When the fluid passes through the micro/nanopillar array it is separated into particles of interest or particles not of interest or both. When particles of interest are lit by a light source via a first waveguide in the microchip connecting the light source to the microfluidic channel, then lighted particles of interest can be detected by an optical detector via a second waveguide in the microchip connecting the optical detector to the microfluidic channel. The information from the optical detector can be analyzed further by connecting the microchip to a mobile computing device with its own processing abilities or abilities via the internet or cloud.

公开(公告)号：US20170059459A1

公开(公告)日：2017-03-02

申请号：US15151745

申请日：2016-05-11

申请人： Ativa Medical Corporation

发明人： Daniel R. McPeak ,  Ka Man Lee

IPC分类号： G01N1/38 ,  B01L3/00 ,  G01N1/30

CPC分类号： G01N1/38 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502776 ,  B01L2200/06 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0457 ,  G01N1/30 ,  G01N1/31 ,  G01N15/1484 ,  G01N33/4915 ,  G01N2001/386 ,  G01N2015/0065 ,  G01N2015/035 ,  G01N2015/1006 ,  G01N2015/1411 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2035/00148 ,  G01N2035/00158

摘要： The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid.

摘要翻译： 在一些实施例中，本说明书提供了一种用于在具有限定用于包括颗粒物质的流体的流动路径的入口通道的回路中混合流体的装置，与入口通道流体连通并限定第一试剂流的第一试剂通道 第一试剂的通路，入口通道和第一试剂通道，其构造成在第一接合处从入口通道剪切进入第一试剂通道的流体，与入口通道流体连通的剪切通道和第一接合处的第一试剂通道 以及在第二连接处与剪切通道流体连通的扩散通道，所述剪切流体可收集到扩散通道中，使得流体至少部分地被第一试剂压缩以具有接近颗粒直径的厚度 在流体中的物质。