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    FLUID PROCESSING MICRO-FEATURE DEVICES AND METHODS
    1.
    发明申请
    FLUID PROCESSING MICRO-FEATURE DEVICES AND METHODS 审中-公开

    公开(公告)号：US20200033239A1

    公开(公告)日：2020-01-30

    申请号：US16543993

    申请日：2019-08-19

    申请人： Ativa Medical Corporation

    发明人： Daniel R. McPeak ,  Ka Man Lee

    IPC分类号： G01N1/38 ,  B01L3/00 ,  G01N1/30 ,  G01N15/14 ,  G01N1/31

    摘要： The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid.

    Fluid holding and dispensing micro-feature
    2.
    发明授权
    Fluid holding and dispensing micro-feature 有权

    公开(公告)号：US11071982B2

    公开(公告)日：2021-07-27

    申请号：US15755676

    申请日：2016-08-29

    申请人： ATIVA MEDICAL CORPORATION

    发明人： Phillip Henning ,  Elizabeth Palaima ,  Pamela Wong ,  Daniel R. McPeak ,  Ka Man Lee ,  Eric R. Peltola

    IPC分类号： G01N1/40 ,  G01N33/80 ,  B01L3/00 ,  C12Q1/24 ,  G01N15/06 ,  G01N15/04 ,  G01N15/00 ,  G01N15/14

    摘要： Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature and/or multiple lysing channel structures. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, a soluble surface coating on a portion of the one or more surfaces of the chamber, and an outlet port to dispense at least a portion of the fluid from the chamber. In some implementations, the particle-laden fluid may be whole blood, and the soluble surface coating may include reagents and/or dyes that are diffused into the whole blood received within the chamber to generate signals to visualize various cellular components. In some implementations, the apparatus may also include a second soluble surface coating on portions of surfaces of the multiple lysing channel structures.

    FLUID HOLDING AND DISPENSING MICRO-FEATURE
    4.
    发明申请
    FLUID HOLDING AND DISPENSING MICRO-FEATURE 审中-公开
    流体保持和分配微特征

    公开(公告)号：US20170059590A1

    公开(公告)日：2017-03-02

    申请号：US14837524

    申请日：2015-08-27

    申请人： Ativa Medical Corporation

    发明人： Daniel R. McPeak ,  Ka Man Lee ,  Eric R. Peltola

    IPC分类号： G01N33/80 ,  G01N1/40

    CPC分类号： C12Q1/24 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/16 ,  B01L2400/0457 ,  G01N1/4077 ,  G01N33/80

    摘要： Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, and an outlet port to dispense at least a portion of the fluid from the chamber. The outlet port may have a normal vector that, when the apparatus is positioned to dispense the fluid, is substantially perpendicular to gravity. The apparatus may be used to measure a number of individual particles from the fluid that flow through the outlet port over a period of them, measure a total volume of the fluid dispensed through the outlet port over the period of time, and calculate a concentration of the particulate matter within the chamber. In some implementations, the particle-laden fluid may be whole blood.

    摘要翻译： 用于从流体保持和分配微特征分配含颗粒的流体的装置，系统和方法。 在一些实施方式中，该装置包括：具有一个或多个表面的腔室，其限定容积以容纳含有颗粒物质的流体，以及从腔室分配至少一部分流体的出口。 出口可以具有法向量，当装置定位成分配流体时，其基本上垂直于重力。 该装置可用于在其一段时间内从流经出口的流体中测量多个单个颗粒，测量在一段时间内通过出口分配的流体的总体积，并计算浓度 室内的颗粒物。 在一些实施方案中，载有颗粒的流体可以是全血。

    FLUID HOLDING AND DISPENSING MICRO-FEATURE
    5.
    发明申请
    FLUID HOLDING AND DISPENSING MICRO-FEATURE 审中-公开

    公开(公告)号：US20190022651A1

    公开(公告)日：2019-01-24

    申请号：US15755676

    申请日：2016-08-29

    申请人： ATIVA MEDICAL CORPORATION

    发明人： Phillip Henning ,  Elizabeth Palaima ,  Pamela Wong ,  Daniel R. McPeak ,  Ka Man Lee ,  Eric R. Peltola

    IPC分类号： B01L3/00 ,  C12Q1/24 ,  G01N1/40 ,  G01N33/80

    摘要： Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature and/or multiple lysing channel structures. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, a soluble surface coating on a portion of the one or more surfaces of the chamber, and an outlet port to dispense at least a portion of the fluid from the chamber. In some implementations, the particle-laden fluid may be whole blood, and the soluble surface coating may include reagents and/or dyes that are diffused into the whole blood received within the chamber to generate signals to visualize various cellular components. In some implementations, the apparatus may also include a second soluble surface coating on portions of surfaces of the multiple lysing channel structures.

    Fluid processing micro-feature devices and methods
    7.
    发明授权
    Fluid processing micro-feature devices and methods 有权
    流体加工微特征装置和方法

    公开(公告)号：US09366606B1

    公开(公告)日：2016-06-14

    申请号：US14837697

    申请日：2015-08-27

    申请人： Ativa Medical Corporation

    发明人： Daniel R. McPeak ,  Ka Man Lee

    IPC分类号： G01N1/38 ,  G01N33/50 ,  B01L3/00 ,  B01F13/00

    CPC分类号： G01N1/38 ,  B01F13/0062 ,  B01F13/0093 ,  B01L3/5027 ,  B01L3/502776 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487

    摘要： The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid.

    摘要翻译： 在一些实施例中，本说明书提供了一种用于在具有限定用于包括颗粒物质的流体的流动路径的入口通道的回路中混合流体的装置，与入口通道流体连通并限定第一试剂流的第一试剂通道 第一试剂的通路，入口通道和第一试剂通道，其构造成在第一接合处从入口通道剪切进入第一试剂通道的流体，与入口通道流体连通的剪切通道和第一接合处的第一试剂通道 以及在第二连接处与剪切通道流体连通的扩散通道，所述剪切流体可收集到扩散通道中，使得流体至少部分地被第一试剂压缩以具有接近颗粒直径的厚度 在流体中的物质。