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    Novel phosphorus-containing thyromimetics
    2.
    发明申请
    Novel phosphorus-containing thyromimetics 失效
    新型含磷甲状腺素

    公开(公告)号：US20060046980A1

    公开(公告)日：2006-03-02

    申请号：US11137773

    申请日：2005-05-26

    Applicant: Mark Erion ,  Hongjian Jiang ,  Serge Boyer

    Inventor： Mark Erion ,  Hongjian Jiang ,  Serge Boyer

    IPC: A61K31/675 ,  A61K31/66 ,  C07F9/12

    CPC classification number: C07F9/4056 ,  C07F9/301 ,  C07F9/306 ,  C07F9/3808 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4075 ,  C07F9/4407 ,  C07F9/4465 ,  C07F9/5728 ,  C07F9/58 ,  C07F9/65517 ,  C07F9/657181

    Abstract: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

    Abstract translation: 本发明涉及含膦酸的T3模拟物及其单酯的化合物，其立体异构体，药学上可接受的盐，共晶体和前药以及其药学上可接受的盐和共结晶，以及它们的制备和用途 预防和/或治疗诸如肥胖，NASH，高胆固醇血症和高脂血症的代谢疾病，以及相关病症如动脉粥样硬化，冠心病，葡萄糖耐量降低，代谢综合症x和糖尿病。

    Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates
    7.
    发明授权
    Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates 失效
    通过双（酰氧基）丙基磷酰胺酸盐从骨髓中选择性消除恶性细胞

    公开(公告)号：US5055459A

    公开(公告)日：1991-10-08

    申请号：US335016

    申请日：1989-04-06

    Applicant: Borje S. Andersson ,  David Farquhar

    Inventor： Borje S. Andersson ,  David Farquhar

    IPC: C07F9/24 ,  C07F9/44 ,  C07H15/252 ,  C07H19/10

    CPC classification number: C07H15/252 ,  C07F9/2408 ,  C07F9/2433 ,  C07F9/245 ,  C07F9/2458 ,  C07F9/2479 ,  C07F9/2491 ,  C07F9/4407 ,  C07F9/4465 ,  C07H19/10

    Abstract: A method for purging tumor cells from bone marrow of a host, the method comprisingextracting bone marrow cells from the host;treating extracted bone marrow cells with a therapeutic level of a compound having the structure: ##STR1## wherein R is CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, t-C.sub.4 H.sub.9 or C.sub.6 H.sub.5 ; R.sup.1 is NH.sub.2, NHCH.sub.3, NHC.sub.2 H.sub.5, NHC.sub.3 H.sub.7, NHC.sub.4 H.sub.9, NHCH.sub.2 CH.sub.2 Cl, NHC.sub.6 H.sub.5, N(CH.sub.3).sub.2, N(C.sub.2 H.sub.5).sub.2, N(C.sub.3 H.sub.7).sub.2, NCH.sub.3 (C.sub.2 H.sub.5), NCH.sub.3 (C.sub.3 H.sub.7), N(CH.sub.2 CH.sub.2 Cl).sub.2, NHOH, NHNHCO.sub.2 CH.sub.2 C.sub.6 H.sub.5, NHNHCO.sub.2 C(CH.sub.3).sub.3, OCH.sub.3, OC.sub.2 H.sub.5, OC.sub.3 H.sub.7, OC.sub.4 H.sub.9, OC.sub.6 H.sub.5, OCH.sub.2 C.sub.6 H.sub.5, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, CH.sub.2 NO.sub.2 or CH.sub.2 NH.sub.2 ; and R.sup.2 is NHCH.sub.2 CH.sub.2 Cl or N(CH.sub.2 Ch.sub.2 Cl).sub.2. Intravascularly infusion of the treated bone marrow cells into the host then serves to reimplant tumor-free marrow cells.

    Abstract translation: 一种用于从宿主骨髓中清除肿瘤细胞的方法，所述方法包括从宿主中提取骨髓细胞; 用治疗水平的具有以下结构的化合物处理提取的骨髓细胞：其中R是CH 3，C 2 H 5，C 3 H 7，t-C 4 H 9或C 6 H 5; R1是NH2，NHCH3，NHC2H5，NHC3H7，NHC4H9，NHCH2CH2Cl，NHC6H5，N（CH3）2，N（C2H5）2，N（C3H7）2，NCH3（C2H5），NCH3（C3H7），N（CH2CH2Cl） NHOH，NHNHCO2CH2C6H5，NHNHCO2C（CH3）3，OCH3，OC2H5，OC3H7，OC4H9，OC6H5，OCH2C6H5，CH3，C2H5，C3H7，C4H9，CH2NO2或CH2NH2; 并且R 2是NHCH 2 CH 2 Cl或N（CH 2 CH 2 Cl）2。 将处理过的骨髓细胞血管内输注到宿主中，然后用于再植入无肿瘤的骨髓细胞。

    N-substituted-p-(2-chloroethyl)-phosphonamidates
    9.
    发明授权
    N-substituted-p-(2-chloroethyl)-phosphonamidates 失效
    N-取代对 - （2-氯乙基） - 膦酰胺化物

    公开(公告)号：US3951969A

    公开(公告)日：1976-04-20

    申请号：US441859

    申请日：1974-02-12

    Applicant: David I. Randall ,  Robert W. Wynn

    Inventor： David I. Randall ,  Robert W. Wynn

    IPC: C07F9/38 ,  C07F9/44 ,  C07F9/59 ,  C07F9/6533 ,  C07D295/00

    CPC classification number: C07F9/6533 ,  C07F9/3808 ,  C07F9/4407 ,  C07F9/591

    Abstract: Plant growth regulating compounds are N-substituted-P-(2-chloroethyl)-phosphonamidic esters of the formula: ##EQU1## wherein R is cycloalkyl, R.sub.1 is hydrogen or cycloalkyl or R and R.sub.1 together form a heterocyclic ring such as morpholine, piperidine or pyrrolidine and R.sub.2 is alkyl or haloalkyl. They are prepared by the reaction of 2-chloroethylphosphonohalidic esters with the appropriate secondary amine.

    Abstract translation: 植物生长调节化合物是下式的N-取代的P-（2-氯乙基） - 膦酰胺基酯：其中R是环烷基，R 1是氢或环烷基，或者R和R 1在一起 形成杂环，如吗啉，哌啶或吡咯烷，R2是烷基或卤代烷基。 它们通过2-氯乙基膦酰卤酯与适当的仲胺的反应制备。

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