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162 条记录 (耗时 0.037 秒)

    Quinazoline derivatives
    1.
    发明授权
    Quinazoline derivatives 失效
    喹唑啉衍生物

    公开(公告)号：US07141577B2

    公开(公告)日：2006-11-28

    申请号：US10475016

    申请日：2002-04-15

    申请人： Patrick Ple

    发明人： Patrick Ple

    IPC分类号： A61K31/517 ,  C07D47/02

    CPC分类号： C07D405/12

    摘要： The invention concerns quinazoline derivatives of Formula I (A Chemical Formula should be inserted here—please see paper copy enclosed) wherein each of Z, m, R1, n and R3 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumor disease.

    摘要翻译： 本发明涉及式I的喹唑啉衍生物（A化学式应在此插入 - 请参见附有文件的复印件），其中Z，m，R 1，n和R 3 >具有上文在描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

    Thrombin receptor antagonists
    6.
    发明申请
    Thrombin receptor antagonists 有权
    凝血酶受体拮抗剂

    公开(公告)号：US20040152736A1

    公开(公告)日：2004-08-05

    申请号：US10671216

    申请日：2003-09-25

    发明人： Samuel Chackalamannil ,  Mariappan V. Chelliah ,  Yan Xia

    IPC分类号： A61K031/4433 ,  C07D47/02

    CPC分类号： C07D417/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/06 ,  C07D405/14 ,  C07D413/14

    摘要： A series of compounds represented by the structural formulas 1 2 and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and binders to cannabinoid receptors.

    摘要翻译： 公开了一系列由结构式表示的化合物及其药学上可接受的异构体，盐，溶剂化物和多晶型物。 还公开了含有所述化合物的药物组合物及其作为大麻素受体的凝血酶受体拮抗剂和粘合剂的用途。

    Dihydro-furan-2-one derivatives, their intermediates and methods of manufacture
    7.
    发明申请
    Dihydro-furan-2-one derivatives, their intermediates and methods of manufacture 审中-公开
    二氢呋喃-2-酮衍生物，其中间体和制备方法

    公开(公告)号：US20040049057A1

    公开(公告)日：2004-03-11

    申请号：US10431278

    申请日：2003-05-07

    申请人： Pfizer Inc.

    发明人： Frank J. Urban ,  V. John Jasys ,  Zhengong B. Li

    IPC分类号： C07D307/93 ,  C07D305/12 ,  C07D47/02

    CPC分类号： C07D307/33

    摘要： This invention relates to dihydro-furan-2-one derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formula (V-1) 1 wherein R2 and P are herein defined. The present invention also relates to the compounds used in such processes, as well as the compounds made by the processes.

    摘要翻译： 本发明涉及二氢呋喃-2-酮衍生物，其中间体和制备方法。 因此，本发明包括制备其中R 2和P在本文中定义的式（V-1）化合物的方法。 本发明还涉及在这些方法中使用的化合物以及通过该方法制备的化合物。

    Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance
    8.
    发明申请
    Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance 失效
    单硝酸异山梨酯的衍生物及其作为具有降低耐受性的血管舒张剂的用途

    公开(公告)号：US20030225134A1

    公开(公告)日：2003-12-04

    申请号：US10424828

    申请日：2003-04-28

    申请人： LACER, S.A.

    发明人： Jose Repolles Moliner ,  Francisco Pubill Coy ,  Lydia Cabeza Llorente ,  Marcel.li Carbo Banus ,  Cristina Negrie Rofes ,  Juan Antonio Cerda Riudavets ,  Alicia Ferrer Siso ,  Marek W. Radomski ,  Eduardo Perez-Rasilla ,  Juan Martinez Bonnin

    IPC分类号： C07D47/02 ,  C07D493/02 ,  A61K031/4433

    CPC分类号： C07D493/04

    摘要： Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) 1 in which A and B individually represent any of the groups nullONO2 and -Z-COnullR, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, or the group 2 in which R1 is hydrogen, or an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always nullONO2, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group 3

    摘要翻译： 其中A和B各自表示-ONO 2和-Z-CO-R中的任何基团的通式（I）的具有降低的耐受性的血管扩张活性的单硝酸异山梨酯及其药学上可接受的盐的新衍生物， 其中Z是氧原子或硫原子，R是最终取代的烷基C1-C4基团，芳基或芳烷基，或其中R 1是氢的基团或烷基C1-C4基团， 芳基或芳烷基，最终被取代，条件是A或B中的一个一直是-ONO 2，但是当Z是硫原子时，它们同时不是两者，R是烷基C 1 -C 4基团， 芳基或芳烷基，最后被取代，当Z为氧原子时R为基团

    Novel compounds useful, for example, in optical switching and manufacturing method thereof
    9.
    发明申请
    Novel compounds useful, for example, in optical switching and manufacturing method thereof 失效
    新颖的化合物可用于例如光开关及其制造方法

    公开(公告)号：US20030220511A1

    公开(公告)日：2003-11-27

    申请号：US10404655

    申请日：2003-04-02

    申请人： Fuji Xerox Co., Ltd.

    发明人： Minquan Tian ,  Makoto Furuki ,  Lyong Sun Pu ,  Yasuhiro Sato ,  Izumi Iwasa ,  Satoshi Tatsuura

    IPC分类号： C07D47/02

    CPC分类号： C09B23/0075

    摘要： A dibenzofuranonylium methylate compound represented by the following formula (I), having maximum absorption wavelength of over 1 nullm, high thermal stability and good solubility in organic solvents, and a production method thereof are provided: 1 where R1 and R2 may be identical or different from each other and each represents a linear alkyl group or a branched alkyl group, respectively.

    摘要翻译： 提供了具有最大吸收波长超过1μm的下式（I）表示的二苯并呋喃基甲基化钛化合物及其制备方法，其中R1和R2可相同或不同 彼此分别表示直链烷基或支链烷基。