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公开(公告)号：US20230071765A1
公开(公告)日：2023-03-09
申请号：US17758352
申请日：2021-01-04
发明人： Peter B. Heifetz , Haim Moskowitz
摘要： The present disclosure relates to preparations, formulations and uses of a protein or peptide having thioredoxin action for treating diseases and/or conditions. One aspect of the invention is a method to decrease viscoelasticity of mucus or sputum in a patient that has excessively viscous or cohesive mucus or sputum. The method includes contacting the mucus or sputum of the patient with a composition comprising a protein or peptide comprising a thioredoxin monocysteinic active site, wherein the protein or peptide does not contain any cysteine residues except for a single Cys at the N-terminal position of the thioredoxin monocysteinic active site.
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公开(公告)号：US20110171161A1
公开(公告)日：2011-07-14
申请号：US13119216
申请日：2009-09-17
IPC分类号： A61K38/10 , C08G65/333 , A61P31/00
摘要： The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and/or reduced clearance.
摘要翻译： 本发明提供了通过共价连接水溶性寡聚物进行化学修饰的整合素。 本发明的共轭物具有增强的半衰期和/或减少的间隙。
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公开(公告)号：US20110165113A1
公开(公告)日：2011-07-07
申请号：US13119236
申请日：2009-09-17
申请人： Steven O. Roczniak , Ping Zhang , Haim Moskowitz
发明人： Steven O. Roczniak , Ping Zhang , Haim Moskowitz
CPC分类号： C07K14/4723 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US06475763B1
公开(公告)日：2002-11-05
申请号：US09487716
申请日：2000-01-19
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
IPC分类号： C12Q100
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
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公开(公告)号：US20110166063A1
公开(公告)日：2011-07-07
申请号：US13119297
申请日：2009-09-17
申请人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
发明人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
IPC分类号： A61K38/28 , A61K38/16 , A61K38/08 , A61K38/06 , A61K38/07 , A61K38/10 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/00 , A61P3/10
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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6.发明申请公开(公告)号：US20050158708A1
公开(公告)日：2005-07-21
申请号：US10480149
申请日：2002-06-06
申请人： Iris Alroy , Haim Moskowitz , Yuval Reiss , Benjamin Shoham
发明人： Iris Alroy , Haim Moskowitz , Yuval Reiss , Benjamin Shoham
IPC分类号： C07D207/40 , C07D207/416 , C07D319/06 , C07D405/12 , C07D491/04 , C07D491/14 , C07F5/02 , C07K1/107 , C07K1/13 , C07K14/705 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/554 , G01N33/567 , G01N33/58 , G01N33/68 , C07D47/02
CPC分类号： C07D405/12 , C07D207/416 , C07D319/06 , C07D491/04 , C07D491/14 , C07F5/025 , C07K1/1077 , C07K1/13 , C07K14/705 , G01N33/5005 , G01N33/554 , G01N33/582 , G01N33/6803
摘要： This invention relates to methods and reagents for selectively labeling membrane surface proteins using a labeling agent. The label may be used to isolate preparations of membrane surface proteins. Preparations of membrane surface proteins may be analysed by a variety of high-throughput techniques to allow rapid profiling of membrane surface protein composition.
摘要翻译： 本发明涉及使用标记试剂选择性标记膜表面蛋白的方法和试剂。 该标记可用于分离膜表面蛋白的制备物。 可以通过各种高通量技术分析膜表面蛋白质的制备，以允许膜表面蛋白质组成的快速分析。
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7.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06348344B1
公开(公告)日：2002-02-19
申请号：US09260038
申请日：1999-03-02
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
IPC分类号： C12N942
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
摘要翻译： 细菌，酵母和动物细胞和细胞系中过表达重组肝素酶的方法，从其中纯化重组肝素酶的方法和通过蛋白水解产生高活性乙酰肝素酶的前体的修饰的乙酰肝素酶。
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公开(公告)号：US6162430A
公开(公告)日：2000-12-19
申请号：US20216
申请日：1998-02-06
IPC分类号： C12N15/09 , A01N63/02 , C07K14/435 , C12N7/00 , C12N7/01 , C12N15/866 , C12R1/92 , A01N63/00 , A01N37/18 , C07K2/00
CPC分类号： C12N15/86 , A01N63/02 , C07K14/43522 , C12N2710/14143 , Y10S530/858 , A01N2300/00
摘要： A method is provided that accelerates the rate of kill of pests such as from the order Lepidoptera. The method comprises treating the pests or their loci with at least two different insect toxins which are expressed from at least one recombinant microbe. Pairs of toxins that do not compete with each other on the same binding site and that differ in their pharmacology have been found to provide synergistic control. Preferred insecticidal microbes are baculoviruses.
摘要翻译： 提供了一种加速杀虫害的速度的方法，例如鳞翅目。 该方法包括用至少两种由至少一种重组微生物表达的不同昆虫毒素处理害虫或其基因座。 已经发现，在相同结合位点上彼此不竞争并且其药理学不同的毒素对已经被发现提供协同控制。 优选的杀虫微生物是杆状病毒。
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公开(公告)号：US5756340A
公开(公告)日：1998-05-26
申请号：US435040
申请日：1995-05-08
IPC分类号： C12N15/09 , A01N63/02 , C07K14/435 , C12N7/00 , C12N7/01 , C12N15/866 , C12R1/92 , A01N63/00
CPC分类号： C12N15/86 , A01N63/02 , C07K14/43522 , C12N2710/14143 , Y10S530/858
摘要： A method is provided that accelerates the rate of kill of pests such as from the order Lepidoptera. The method comprises treating the pests or their loci with at least two different insect toxins which are expressed from at least one recombinant microbe. Pairs of toxins that do not compete with each other on the same binding site and that differ in their pharmacology have been found to provide synergistic control. Preferred insecticidal microbes are baculoviruses.
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公开(公告)号：US20050181355A1
公开(公告)日：2005-08-18
申请号：US10485225
申请日：2002-07-31
申请人： Tsvika Greener , Haim Moskowitz , Yuval Reiss , Iris Alroy
发明人： Tsvika Greener , Haim Moskowitz , Yuval Reiss , Iris Alroy
IPC分类号： C07H21/04 , C07K14/16 , C07K14/47 , C07K16/08 , C12N9/00 , C12N15/33 , C12N15/867 , C12Q1/70
CPC分类号： C07K14/005 , C07K14/47 , C07K16/08 , C12N9/93 , C12N2740/16023 , C12N2740/16222 , C12Y603/02019 , G01N2500/20
摘要： This application describes a family of nucleic acid sequences and proteins encoded thereby that play a role in viral maturation: the Alternate Viral Maturation Scaffolding Protein, or the AVMSP family of proteins.
摘要翻译： 该应用描述了一系列由其编码的核酸序列和蛋白质，其在病毒成熟中起作用：替代病毒成熟脚手架蛋白或AVMSP蛋白家族。
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