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    Polyanionic compounds, process for their preparation and compositions in which they are present
    1.
    发明授权
    Polyanionic compounds, process for their preparation and compositions in which they are present 失效
    聚阴离子化合物，其制备方法及其存在的组合物

    公开(公告)号：US4814166A

    公开(公告)日：1989-03-21

    申请号：US867003

    申请日：1986-05-20

    Applicant: Guy Vanlerberghe ,  Henri Sebag

    Inventor： Guy Vanlerberghe ,  Henri Sebag

    IPC: C11D1/06 ,  A61K8/00 ,  A61K8/04 ,  A61K8/34 ,  A61K8/39 ,  A61K8/46 ,  A61K8/84 ,  A61K8/86 ,  A61K8/92 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/12 ,  C07C315/04 ,  C07C317/00 ,  C07C317/44 ,  C07C319/20 ,  C07C321/14 ,  C08G65/24 ,  C08G65/32 ,  C08G65/331 ,  C08G65/334 ,  C08G75/00 ,  C08L81/00 ,  C09K3/00 ,  C11D1/37 ,  C11D3/20 ,  A61K7/06 ,  C07C149/20

    CPC classification number: A61K8/84 ,  A61K8/46 ,  A61Q5/02 ,  A61Q5/12 ,  C07C317/00 ,  C07C323/00 ,  C08G65/24 ,  C08G65/331 ,  C08G65/334

    Abstract: Anionic oligomers of the general formula: ##STR1## in which T denotes the radical ##STR2## optionally in a mixture with the OH radical; u=0 or 1; p=1 or 2; M=H, Na, K, ammonium or a mono-, di- or tri-(alkyl or hydroxyalkyl)ammonium group, the alkyl part containing 1 to 4 carbon atoms; n=5-30; z=1-6; and R denotes an aliphatic, alicyclic, aryl, alkylaryl or aralkyl radical of valency z, which can contain 1 or more oxygen atoms, it being possible for the formula (I) to contain minor proportions of intermolecular or intra-molecular branches originating from a bis-epoxide.These oligomers are prepared by the addition of n mols of epihalogenohydrin, and optionally of a minor proportions of bis-epoxide, to 1 mol of compoundsR(OH).sub.z (II),in the presence of a Lewis acid, the polyhalogen compounds obtained then being converted into polythiocarboxylic compounds by reaction with a salt or an ester of thiloactic acid, thioglycolic acid or .alpha.-mercaptopropionic or .beta.-mercaptopropionic acid, and the resulting compounds, after saponification, if appropriate, being acidified and neutralized with NaOH, KOH, NH.sub.4 OH or an amine, and optionally oxidized or sulphoxidized.The compositions containing oligomers (I) are suitable for the treatment of keratin fibres, textiles and water.

    Abstract translation: 阴离子低聚物，其通式为：其中T表示基团，任选地与OH基团的混合物中; u = 0或1; p = 1或2; M = H，Na，K，铵或单 - ，二 - 或三 - （烷基或羟烷基）铵基团，烷基部分含有1至4个碳原子; n = 5-30; z = 1-6; 并且R表示价数z的脂族，脂环族，芳基，烷基芳基或芳烷基，其可以含有1个或更多个氧原子，式（I）可能含有少量的分子间或分子内分子， 双环氧化物。 通过在路易斯酸存在下，将1摩尔的表卤代醇和任选的少量双环氧化物加入1摩尔的化合物R（OH）z（II）中，得到的多卤素化合物制备这些低聚物 然后通过与硫代酸，巯基乙酸或α-巯基丙酸或β-巯基丙酸的盐或酯反应转化成多硫代羧酸化合物，并且所得化合物在皂化后，如果合适，被酸化并用NaOH，KOH， NH 4 OH或胺，并且任选被氧化或亚砜化。 含有低聚物（I）的组合物适用于治疗角蛋白纤维，纺织品和水。

    Method of making mixed pentaerythritol esters having up to 75 percent thio-containing side chains
    2.
    发明授权
    Method of making mixed pentaerythritol esters having up to 75 percent thio-containing side chains 失效
    制备具有高达75％含硫侧链的混合季戊四醇酯的方法

    公开(公告)号：US4806675A

    公开(公告)日：1989-02-21

    申请号：US111470

    申请日：1987-10-19

    Applicant: Neil Dunski ,  Ali A. Bazzi

    Inventor： Neil Dunski ,  Ali A. Bazzi

    IPC: C08K5/10 ,  C07C67/00 ,  C07C69/612 ,  C07C69/732 ,  C07C313/00 ,  C07C323/16 ,  C07C323/22 ,  C07C323/52 ,  C08K5/13 ,  C08K5/24 ,  C08K5/37 ,  C08K5/375 ,  C09K15/14 ,  C07C149/20

    CPC classification number: C10L1/2418 ,  C07C323/00 ,  C08K5/375

    Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-dodecylthiopropionate] and (II) pentaerythritol bis[-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopropionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenylalkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.

    Abstract translation: 衍生自季戊四醇，（3-烷基-4-羟基苯基） - 链烷酸和烷基硫代链烷酸或这些酸的低级烷基酯的季戊四醇共 - 酯可用作通常易于氧化和/或热退化的有机材料的稳定剂。 共聚酯有利地通过这种酯与季戊四醇的酯交换制备。 优选的共酯是（I）季戊四醇三[3,5-二叔丁基-4-羟基苯基]丙酸酯] - 单[3-正十二烷基硫代丙酸酯]和（II）季戊四醇双[ - （3,5- 二叔丁基-4-羟基苯基）丙酸酯]双[3-正十二烷基硫代丙酸酯]。 共聚酯特别可用于稳定其中（i）（3-烷基-4-羟基苯基链烷酸酯的多元醇与（ii）烷基硫代链烷酸的聚链烷醇酯的物理混合物的物质混合物的稳定应用。

    Pentaerythritol co-esters where up to 75 percent of the acid component is alkylthioalkanoic
    3.
    发明授权
    Pentaerythritol co-esters where up to 75 percent of the acid component is alkylthioalkanoic 失效
    季戊四醇共酯，其中高达75％的酸组分是烷硫基链烷酸

    公开(公告)号：US4794138A

    公开(公告)日：1988-12-27

    申请号：US90819

    申请日：1987-08-28

    Applicant: Neil Dunski ,  Ali A. Bazzi

    Inventor： Neil Dunski ,  Ali A. Bazzi

    IPC: C08K5/10 ,  C07C67/00 ,  C07C69/612 ,  C07C69/732 ,  C07C313/00 ,  C07C323/16 ,  C07C323/22 ,  C07C323/52 ,  C08K5/13 ,  C08K5/24 ,  C08K5/37 ,  C08K5/375 ,  C09K15/14 ,  C07C149/20

    CPC classification number: C10L1/2418 ,  C07C323/00 ,  C08K5/375

    Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-do-decylthiopropionate] and (II) pentaerythritol bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopropionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenyl)alkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.

    Abstract translation: 衍生自季戊四醇，（3-烷基-4-羟基苯基） - 链烷酸和烷基硫代链烷酸或这些酸的低级烷基酯的季戊四醇共 - 酯可用作通常易于氧化和/或热退化的有机材料的稳定剂。 共聚酯有利地通过这种酯与季戊四醇的酯交换制备。 优选的共酯是（I）季戊四醇三[3-（3,5-二叔丁基-4-羟基苯基）丙酸酯] - 单[3-n-do-decy硫代丙酸酯]和（II）季戊四醇双[3 - （3,5-二叔丁基-4-羟基苯基）丙酸酯] - 双[3-正十二烷基硫代丙酸酯]。 共聚酯特别可用于稳定应用，其中（i）多元醇的（3-烷基-4-羟基苯基）烷酸酯与（ii）烷基硫代链烷酸的聚链烷醇酯的物理混合物迄今已被提出。

    Pentaerythritol co-esters
    5.
    发明授权
    Pentaerythritol co-esters 失效
    季戊四醇共酯

    公开(公告)号：US4734519A

    公开(公告)日：1988-03-29

    申请号：US871007

    申请日：1986-06-05

    Applicant: Neil Dunski ,  Ali A. Bazzi

    Inventor： Neil Dunski ,  Ali A. Bazzi

    IPC: C08K5/10 ,  C07C67/00 ,  C07C69/612 ,  C07C69/732 ,  C07C313/00 ,  C07C323/16 ,  C07C323/22 ,  C07C323/52 ,  C08K5/13 ,  C08K5/24 ,  C08K5/37 ,  C08K5/375 ,  C09K15/14 ,  C07C149/20

    CPC classification number: C10L1/2418 ,  C07C323/00 ,  C08K5/375

    Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3-(3,5-di-tert-butyl-4-hydroxylphenyl)propionate]-mono[3-n-dodecylthiopropionate] and (II) pentaerythritol bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopropionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenyl)alkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.

    Aliphatic thioethers
    6.
    发明授权
    Aliphatic thioethers 失效
    脂族硫醚

    公开(公告)号：US4649215A

    公开(公告)日：1987-03-10

    申请号：US748656

    申请日：1985-06-25

    Applicant: Andreas von Sprecher ,  Ivan Ernest ,  Alan J. Main ,  Andreas Beck

    Inventor： Andreas von Sprecher ,  Ivan Ernest ,  Alan J. Main ,  Andreas Beck

    IPC: A61K38/00 ,  C07D309/12 ,  C07K5/06 ,  C07C149/20 ,  C07C147/02

    CPC classification number: C07K5/06191 ,  C07C323/00 ,  C07D309/12 ,  C07K5/0606 ,  A61K38/00

    Abstract: Novel asymmetric thioethers of the formula ##STR1## in which R.sup.1 represents a C.sub.1-3 -alkyl radical or a C.sub.1-3 -hydroxyalkyl radical of which the hydroxy group may be in esterified form,R.sup.2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms,R.sup.3 represents hydroxy, alkoxy or an optionally substituted amino group, and-X- represents a single bond, a methylene group or an optionally N-acylated primary aminomethylene groupwherein the O-atom of the hydroxy group is in the transconfiguration relative to the S-atom, are effective as leucotriene-antagonists since they eliminate the contractions of smooth muscles caused by leucotrienes and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.

    Abstract translation: 式（I）的新型不对称硫醚，其中R 1表示C 1-3 - 烷基或羟基可以被酯化形成的C 1-3 - 羟基烷基，R 2表示具有 5至15个碳原子，R 3表示羟基，烷氧基或任选取代的氨基，-X-表示单键，亚甲基或任选N-酰化的伯氨基亚甲基，其中羟基的O-原子是 在相对于S原子的反式构型中，作为白三烯拮抗剂是有效的，因为它们消除了由白三烯引起的平滑肌的收缩，因此适用于治疗变态反应，特别是哮喘病症。

    Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
    7.
    发明授权
    Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them 失效
    羧酸衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US4609673A

    公开(公告)日：1986-09-02

    申请号：US682935

    申请日：1984-12-18

    Applicant: Hermann Eggerer ,  Bernd Hagenbruch ,  Tran G. Nguyen ,  Karlheinz Stegmeier ,  Johannes Pill

    Inventor： Hermann Eggerer ,  Bernd Hagenbruch ,  Tran G. Nguyen ,  Karlheinz Stegmeier ,  Johannes Pill

    IPC: A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/23 ,  A61P3/06 ,  C07C67/00 ,  C07C301/00 ,  C07C313/00 ,  C07C315/04 ,  C07C317/44 ,  C07C317/46 ,  C07C323/51 ,  C07C149/20 ,  C07C147/05

    CPC classification number: A61K31/23

    Abstract: The present invention provides carboxylic acid derivatives of the general formula: ##STR1## wherein R is a hydrogen atom, alkyl, a metal cation or an ammonium or alkylammonium ion, R.sub.1 is a hydrogen atom, a hydroxyl group or an alkyl, O-alkyl,O-benzyl or O-acyl radical, R.sub.2 is a hydrogen atom or an alkyl, aryl or aralkyl radical, n is 0, 1 or 2 and R.sub.3 is an acyl radical, this radical being(a) a straight-chained or branched, saturated or unsaturated alkanoyl radical containing 2 to 11 carbon atoms; or(b) the radical ##STR2## in which A is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 4 carbon atoms, which is optionally substituted by hydroxyl, and B is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 8 carbon atoms, which is optionally substituted one or more times by hydroxyl, carboxyl or phenyl, or B is a phenyl or cycloalkyl radical; or(c) the radical ##STR3## in which A and B have the same meanings as in (b) and R.sub.4 is a hydrogen atom or an alkyl or aralkyl radical; as well as the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.

    Abstract translation: 本发明提供以下通式的羧酸衍生物：其中R是氢原子，烷基，金属阳离子或铵或烷基铵离子，R1是氢原子，羟基或烷基， O-烷基，O-苄基或O-酰基，R2是氢原子或烷基，芳基或芳烷基，n是0,1或2，R3是酰基，该基团是（a） 含有2至11个碳原子的链或支链，饱和或不饱和烷酰基; 或（b）其中A是含有至多4个碳原子的直链或支链，饱和或不饱和的脂族烃基的基团，其任选被羟基取代，B是直链或支链的， 含有至多8个碳原子的饱和或不饱和脂族烃基，其任选被羟基，羧基或苯基取代一次或多次，或B是苯基或环烷基; 或（c）其中A和B具有与（b）中相同含义的基团，R4为氢原子或烷基或芳烷基; 以及其药理学上可接受的盐。 本发明还提供了制备这些化合物的方法，以及含有它们的药物组合物。

    Method of sulfation
    9.
    发明授权
    Method of sulfation 失效
    硫酸化方法

    公开(公告)号：US4444682A

    公开(公告)日：1984-04-24

    申请号：US439312

    申请日：1982-11-04

    Applicant: Jean E. F. Rivier ,  Botond Penke

    Inventor： Jean E. F. Rivier ,  Botond Penke

    IPC: C07D207/16 ,  C07D213/20 ,  C07D213/74 ,  C07K1/00 ,  C07K7/23 ,  C07K14/595 ,  C07C103/52 ,  C07C147/02 ,  C07C149/20 ,  C07C149/40

    CPC classification number: C07D213/20 ,  C07D207/16 ,  C07D213/74 ,  C07K1/006 ,  C07K14/595 ,  C07K7/23 ,  Y10S930/13

    Abstract: A method for sulfating a hydroxy amino acid or a residue of such an amino acid in a peptide by reaction with a reagent which is a tertiaryammonium salt of acetylsulfuric acid having the formula:[CH.sub.3 COOSO.sub.3 ].sup.- [R].sup.+wherein R is triethylamine, ethyldiisopropylamine, pyridine, 4-methylmorpholine or 4-N,N-dimethylaminopyridine. The .alpha.-amino group and any other labile side chains present may be protected or may be left unprotected at the time the sulfation takes place.

    Abstract translation: 通过与具有下式的[CH3COOSO3] - [R] +的乙酰硫酸的叔铵盐的试剂反应来硫酸化肽中的羟基氨基酸或这种氨基酸的残基的方法，其中R是三乙胺，乙基二异丙胺 ，吡啶，4-甲基吗啉或4-N，N-二甲基氨基吡啶。 存在的α-氨基和任何其它不稳定的侧链可以被保护，或者可能在硫酸化发生时不被保护。

    Recovery of mercaptoalkanoic acids using alkylene glycol ethers
    10.
    发明授权
    Recovery of mercaptoalkanoic acids using alkylene glycol ethers 失效
    使用亚烷基二醇醚回收巯基链烷酸

    公开(公告)号：US4322550A

    公开(公告)日：1982-03-30

    申请号：US193871

    申请日：1980-10-03

    Applicant: James B. Kimble

    Inventor： James B. Kimble

    IPC: C07C148/04 ,  C07C149/20 ,  C07C149/22 ,  C07C149/26

    CPC classification number: C07C319/28 ,  C07C2101/14

    Abstract: Various mercaptoalkanoic acids are recovered from an aqueous medium or water in which they are contained by a liquid-liquid solvent extraction operation employing at least one of an alkanoic acid ester and an alkylene glycol ether. In one embodiment, thioglycolic acid has been extracted with ethyl acetate. In another embodiment, it has been recovered with ethylene glycol monoethyl ether acetate. In a further embodiment, it has been recovered with diethylene glycol diethyl ether.

    Abstract translation: 通过使用链烷酸酯和亚烷基二醇醚中的至少一种的液 - 液溶剂萃取操作从含水介质或水中回收各种巯基链烷酸。 在一个实施方案中，巯基乙酸已经用乙酸乙酯萃取。 在另一个实施方案中，其已用乙二醇单乙醚乙酸酯回收。 在另一个实施方案中，其已用二甘醇二乙醚回收。

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