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    Poly(ethylene glycol) and poly(ethylene oxide) by initiated chemical vapor deposition
    4.
    发明授权
    Poly(ethylene glycol) and poly(ethylene oxide) by initiated chemical vapor deposition 失效
    聚（乙二醇）和聚（环氧乙烷）通过引发化学气相沉积

    公开(公告)号：US08609193B2

    公开(公告)日：2013-12-17

    申请号：US13203425

    申请日：2010-03-17

    申请人： Kenneth K. S. Lau ,  Ranjita K. Bose

    发明人： Kenneth K. S. Lau ,  Ranjita K. Bose

    IPC分类号： C23C16/44 ,  C08G65/28

    CPC分类号： C08G65/105 ,  C08G65/2654 ,  C08G65/266 ,  C08G65/2678 ,  C08G65/2684

    摘要： A method for ionic polymerization of ethylene oxide. In the first step of the method, a gaseous monomer composition comprising ethylene oxide at a first flow rate is mixed with a gaseous ionic polymerization initiator at a second flow rate, thereby forming a mixture. The formed mixture is then heated with at least one heated filament to thereby form at least one polymer. The method may also be employed to coat a variety of different substrates in situ during the polymerization reaction.

    摘要翻译： 环氧乙烷的离子聚合方法。 在该方法的第一步中，将包含第一流速的环氧乙烷的气态单体组合物与气态离子聚合引发剂以第二流速混合，从而形成混合物。 然后将形成的混合物与至少一个加热的细丝加热，从而形成至少一种聚合物。 该方法也可用于在聚合反应期间原位涂布各种不同的底物。

    POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY
    5.
    发明申请
    POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY 审中-公开
    聚（乙二醇）衍生物用于单一化学

    公开(公告)号：US20130178600A1

    公开(公告)日：2013-07-11

    申请号：US13601606

    申请日：2012-08-31

    申请人： Kevin Sill

    发明人： Kevin Sill

    IPC分类号： C08G65/28

    CPC分类号： C08G65/2609 ,  A61K47/60 ,  C08G65/33337 ,  C08L2203/02

    摘要： The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

    摘要翻译： 本发明提供双官能聚合物，其制备方法及其中间体。 这些化合物可用于各种应用，包括生物活性分子的PEG化。 本发明还提供了使用所述化合物及其组合物的方法。

    COPOLYETHER GLYCOL MANUFACTURING PROCESS
    6.
    发明申请
    COPOLYETHER GLYCOL MANUFACTURING PROCESS 有权
    共聚糖制造工艺

    公开(公告)号：US20120259090A1

    公开(公告)日：2012-10-11

    申请号：US13247794

    申请日：2011-09-28

    申请人： Qun SUN ,  Gary L. KISER ,  Robert D. ORLANDI

    发明人： Qun SUN ,  Gary L. KISER ,  Robert D. ORLANDI

    IPC分类号： C08G65/28 ,  C08G65/30

    CPC分类号： C08G65/10 ,  C08G65/20 ,  C08G65/2609 ,  C08G65/2681 ,  C08G65/2684 ,  C08G65/2687 ,  C08G65/269 ,  C08G65/30

    摘要： The present invention provides a highly efficient process for manufacturing copolyether glycol having a mean molecular weight of from about 650 to about 5000 dalton by polymerization of tetrahydrofuran and at least one alkylene oxide in the presence of an acid catalyst and at least one compound containing reactive hydrogen atoms. More particularly, the invention relates to a process for manufacturing copolyether glycol which comprises recycle to the polymerization reaction step of at least a portion of the oligomeric cyclic ether which is co-produced with the copolyether glycol, said process exhibiting an Space Time Yield value of greater than about 0.9.

    摘要翻译： 本发明通过在酸催化剂和至少一种含有反应性氢的化合物存在下，通过四氢呋喃和至少一种烯化氧的聚合来提供平均分子量为约650至约5000道尔顿的共聚醚二醇的高效方法 原子 更具体地说，本发明涉及一种制备共聚醚二醇的方法，该方法包括将与共聚醚二醇共同生产的至少一部分低聚环醚再循环到聚合反应步骤中，所述方法表现出空时收率值 大于0.9。

    Materials and Food Additives Free of Endocrine Disruptive Activity
    7.
    发明申请
    Materials and Food Additives Free of Endocrine Disruptive Activity 审中-公开
    材料和食品添加剂没有内分泌破坏活动

    公开(公告)号：US20110168657A1

    公开(公告)日：2011-07-14

    申请号：US13033493

    申请日：2011-02-23

    申请人： George D. Bittner

    发明人： George D. Bittner

    IPC分类号： A61J9/00 ,  C08K3/32 ,  C08F110/06 ,  C08F110/02 ,  C08F14/06 ,  C08F12/08 ,  C08G64/06 ,  C08G75/20 ,  C08G65/28 ,  C08G65/38 ,  B32B1/02

    CPC分类号： G01N33/743 ,  A23L3/3463 ,  A23L33/10 ,  C08K5/1345 ,  G01N2500/04 ,  Y10T428/1352 ,  C08L23/02

    摘要： The present invention describes plastic materials and food additives that are free or substantially free from endocrine disruptive chemicals. The plastic materials may be used in products which are exposed to individuals in which endocrine disruptive activity is particularly disadvantageous, such as baby bottles, baby toys, food containers, medical containers, animal cages and medical products. The food additives may be used in food products that are ingested by individuals in which endocrine disruptive activity is particularly disadvantageous, such as newborns or the physically infirm. The present invention also describes a series of assays which, when performed in combination, provide a novel method for determining the presence of endocrine disruptive activity.

    摘要翻译： 本发明描述了游离或基本上不含内分泌破坏性化学物质的塑料材料和食品添加剂。 塑料材料可用于暴露于内分泌破坏活动特别不利的个体的产品，例如婴儿奶瓶，婴儿玩具，食品容器，医疗容器，动物笼和医疗产品。 食品添加剂可用于被内分泌破坏活动特别不利的个体摄入的食品中，例如新生儿或身体虚弱。 本发明还描述了一系列测定，当组合进行时，提供了确定内分泌破坏活性存在的新方法。

    MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE
    8.
    发明申请
    MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权
    改良的生物相关物质，其生产方法和中间体

    公开(公告)号：US20110082277A1

    公开(公告)日：2011-04-07

    申请号：US12942554

    申请日：2010-11-09

    申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yammamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

    发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yammamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

    IPC分类号： C08G65/28 ,  C08G63/06

    CPC分类号： C08G65/329 ,  A61K47/60 ,  C08G65/2609

    摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

    摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

    Process for preparing polyether alcohols with DMC catalysts using specific additives with aromatic hydroxyl functionalization
    9.
    发明申请
    Process for preparing polyether alcohols with DMC catalysts using specific additives with aromatic hydroxyl functionalization 审中-公开
    使用具有芳香族羟基官能化的特定添加剂的DMC催化剂制备聚醚醇的方法

    公开(公告)号：US20090137752A1

    公开(公告)日：2009-05-28

    申请号：US12277852

    申请日：2008-11-25

    申请人： Wilfried Knott ,  Frank Schubert

    发明人： Wilfried Knott ,  Frank Schubert

    IPC分类号： C08G65/28 ,  C08G71/04

    CPC分类号： C08G65/2663 ,  C08G65/2609 ,  C08G2650/58

    摘要： Process for preparing polyether alcohols by polymerization by means of double metal cyanide catalysts (DMC catalysts), characterized in that, before or during the polymerization, one or more, optionally mixed additives consisting of compounds having one or more aromatic structures which may be monosubstituted or else polysubstituted and which have at least one hydroxyl group on the aromatic system are added to the reaction mixture.

    摘要翻译： 通过双金属氰化物催化剂（DMC催化剂）聚合制备聚醚醇的方法，其特征在于在聚合之前或聚合过程中，一种或多种任选混合的添加剂由具有一个或多个芳族结构的化合物组成，所述芳族结构可以是单取代的或 另外多取代并且在芳族体系上具有至少一个羟基被加入到反应混合物中。