公开(公告)号：US11814422B2

公开(公告)日：2023-11-14

申请号：US17474434

申请日：2021-09-14

Applicant: COLZYX AB

Inventor： Matthias Mörgelin ,  Suado Abdillahi

IPC: C07K14/78 ,  A61L27/54 ,  A61K38/00 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61K9/70 ,  A61K9/00

CPC classification number: C07K14/78 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L15/44 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/54 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61P17/02 ,  A61P31/04 ,  C07K14/4723 ,  C07K14/755 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/7023 ,  A61K38/00 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/00 ,  A61L2430/34 ,  C07K2319/00

Abstract: The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US20180333250A1

公开(公告)日：2018-11-22

申请号：US15777657

申请日：2015-11-20

Applicant: Dokter Philippe De Vleeschauwer BV BVBA

Inventor： Phillippe DE VLEESCHAUWER

IPC: A61F2/06 ,  A61L27/16 ,  A61L27/50 ,  A61L27/58 ,  A61L27/22 ,  A61L27/34 ,  B33Y80/00

CPC classification number: A61F2/06 ,  A61B2017/1132 ,  A61F2002/065 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2210/0076 ,  A61F2230/0067 ,  A61F2230/0091 ,  A61F2240/002 ,  A61F2240/004 ,  A61F2250/0039 ,  A61F2250/0097 ,  A61L27/16 ,  A61L27/222 ,  A61L27/34 ,  A61L27/507 ,  A61L27/58 ,  A61L2420/00 ,  B29C64/00 ,  B33Y80/00 ,  C08L27/18

Abstract: The invention pertains to a vascular graft (1) for interposition at a resection of vascular structures, said vascular graft comprising a hollow body (2) elongated along a longitudinal axis (3) which includes a first end (4) defining a first opening (5) and a second end (6) defining a second opening (7), wherein said resection of vascular structures concerns a resection of the carotid bifurcation, and wherein said first end (4) is configured to be attached to the common carotid artery and said second end (6) is configured to be attached to the internal carotid artery or the external carotid artery, and wherein said vascular graft comprises polytetrafluoroethylene, and wherein said vascular graft comprises an inside diameter which decreases from said first end (4) towards said second end (6).

公开(公告)号：US09956324B2

公开(公告)日：2018-05-01

申请号：US15244506

申请日：2016-08-23

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Takao Anzai ,  Kaori Nishida

IPC: A61L31/00 ,  A61L33/06 ,  A61L27/34 ,  A61L31/10 ,  C08F222/28 ,  C09D133/14 ,  C08F220/28

CPC classification number: A61L33/068 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0041 ,  A61L2300/42 ,  A61L2420/00 ,  C08F220/28 ,  C08F2220/281 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  C09D133/14 ,  C08F2220/606

Abstract: The disclosure relates to a medical material including a copolymer having a repeating unit (A) represented by the following formula (1): wherein R11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R12 is a C1-6 alkylene group, R13 and R14 are each independently a C1-4 alkyl group, and R15 is a C1-6 alkylene group, and a repeating unit (B) represented by the following formula (2): wherein R21 is a hydrogen atom or a methyl group, R22 is a C1-6 alkylene group, and R23 is a C1-4 alkyl group. The repeating unit (A) is contained in a proportion of 0.6 to 7 mol % based on all the structural units of the copolymer. The disclosure makes it possible to provide a medical material and a medical device, which exhibit excellent antithrombogenicity even when used under severe conditions prone to thrombus formation.

公开(公告)号：US09868696B2

公开(公告)日：2018-01-16

申请号：US14979782

申请日：2015-12-28

Applicant: Bezwada Biomedical, LLC

Inventor： Rao S Bezwada

IPC: C07C271/22 ,  C07C235/12 ,  A61K47/34 ,  C07C265/12 ,  C07C237/36 ,  C07C265/14 ,  C07C229/42 ,  A61L27/18 ,  A61L31/06 ,  A61L31/10 ,  A61L15/26 ,  A61L17/10 ,  A61L24/04 ,  C07C229/36 ,  C08G18/77 ,  C08G18/78 ,  C08G18/48 ,  C08G18/38 ,  A61L26/00 ,  C08G18/66 ,  C07C235/10 ,  C08G101/00

CPC classification number: C07C235/12 ,  A61K47/34 ,  A61L15/26 ,  A61L17/10 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/18 ,  A61L31/06 ,  A61L31/10 ,  A61L2420/00 ,  C07C229/36 ,  C07C229/42 ,  C07C235/10 ,  C07C237/36 ,  C07C265/12 ,  C07C265/14 ,  C08G18/38 ,  C08G18/48 ,  C08G18/4837 ,  C08G18/6607 ,  C08G18/771 ,  C08G18/7812 ,  C08G2101/00 ,  Y10T428/139 ,  Y10T428/249921 ,  Y10T442/10 ,  C08L77/04

Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

公开(公告)号：US20170265981A1

公开(公告)日：2017-09-21

申请号：US15612981

申请日：2017-06-02

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： JOHN ALLEN HINGSTON ,  MATTHEW B. HOLLYER

IPC: A61F2/00 ,  A61F2/04 ,  A61F2/90 ,  A61F2/95 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61F2/07 ,  A61F2/0077 ,  A61F2/04 ,  A61F2/86 ,  A61F2/90 ,  A61F2/95 ,  A61F2002/009 ,  A61F2002/044 ,  A61F2002/072 ,  A61F2002/9528 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0031 ,  A61F2250/0039 ,  A61F2250/0041 ,  A61F2250/0059 ,  A61L31/048 ,  A61L31/10 ,  A61L31/148 ,  A61L2420/00

Abstract: A medical product comprises a biodegradable filament and a non-biodegradeable coating. The biodegradable filament forms a stent body having a first end portion, a middle portion, and a second end portion opposite the first end portion. The middle portion extends between the first and second end portions. The non-biodegradeable coating encapsulates the at least one biodegradable filament along the middle portion of the stent body. The non-biodegradeable coating forms a barrier such that the non-biodegradeable coating prevents degradation of the at least one biodegradable filament along the middle portion. The first and second end portions are uncoated. After implantation, the end portions of the stent may biodegrade. The middle portion will not biodegrade due to its encapsulation by the non-biodegradeable coating.

公开(公告)号：US20170166756A1

公开(公告)日：2017-06-15

申请号：US15178255

申请日：2016-06-09

Applicant: Northwestern University

Inventor： Phillip B. Messersmith ,  Haeshin Lee

IPC: C09D5/16 ,  C09D179/04

CPC classification number: C09D5/1662 ,  A61L2420/00 ,  A61L2420/08 ,  B05D1/185 ,  B05D5/00 ,  B05D7/5483 ,  C02F1/281 ,  C02F1/285 ,  C02F1/288 ,  C02F2101/20 ,  C08J7/123 ,  C09D5/1681 ,  C09D179/04 ,  C23C18/1608 ,  C23C18/1803 ,  C23C18/1834 ,  C23C18/1844 ,  C23C18/2006 ,  C23C18/2066 ,  C23C18/31 ,  C23C18/40 ,  C23C18/42

Abstract: The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.

公开(公告)号：US20170056553A1

公开(公告)日：2017-03-02

申请号：US15251957

申请日：2016-08-30

Applicant: NovaBone Products, LLC

Inventor： Gregory J. Pomrink ,  Zehra Tosun ,  R. Layne Howell

IPC: A61L27/30 ,  A61L27/18

CPC classification number: A61L27/306 ,  A61B17/8811 ,  A61B17/8816 ,  A61B17/8819 ,  A61L24/02 ,  A61L24/046 ,  A61L27/04 ,  A61L27/10 ,  A61L27/16 ,  A61L27/18 ,  A61L27/30 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/102 ,  A61L2400/06 ,  A61L2420/00 ,  A61L2430/02 ,  C08L71/02 ,  C08L5/00

Abstract: Compositions including bioactive glass ceramic material surface-coated with a metallic material and methods of making and using the metallic material-coated compositions.

Abstract translation: 组合物，包括表面涂覆有金属材料的生物活性玻璃陶瓷材料以及制备和使用金属材料涂覆组合物的方法。

公开(公告)号：US09468707B2

公开(公告)日：2016-10-18

申请号：US14752637

申请日：2015-06-26

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  O. Mikael Trollsas

IPC: A61F2/00 ,  A61F13/00 ,  A61K38/00 ,  A61F2/04 ,  A61L31/10 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/16 ,  A61K31/436 ,  A61L31/06 ,  C08G81/00

CPC classification number: A61L31/10 ,  A61K31/436 ,  A61L29/041 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/00 ,  C08G81/00

Abstract: The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.

公开(公告)号：US09468512B2

公开(公告)日：2016-10-18

申请号：US13877695

申请日：2011-10-06

Applicant: Edouard A. Koullick ,  Thomas Q. Dinh ,  Robert C. Grant

Inventor： Edouard A. Koullick ,  Thomas Q. Dinh ,  Robert C. Grant

IPC: A61F2/02 ,  A61F2/00 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61F2/0045 ,  A61F2/0063 ,  A61F2002/0068 ,  A61F2002/0072 ,  A61F2210/0076 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L31/048 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/18 ,  A61L2420/00 ,  C08L23/06

Abstract: Described are methods, devices, and systems related to implants for the treatment of a female pelvic condition. The implants include absorbable and non-absorbable materials and can be introduced into the pelvic area transvaginally. Meshes of the invention provide benefits relating to improved tissue integration into the mesh, reduced infection likelihood, improved patient comfort following implantation, or combinations of thereof.

Abstract translation: 描述了与用于治疗女性盆腔病症的植入物相关的方法，装置和系统。 植入物包括可吸收和不可吸收的材料，并可经阴道引入骨盆区域。 本发明的网格提供了与改进的组织整合到网中有关的益处，降低的感染可能性，植入后改善的患者舒适度或其组合。

公开(公告)号：US20160250385A1

公开(公告)日：2016-09-01

申请号：US15032677

申请日：2014-11-03

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： D. Kacy CULLEN ,  Douglas H. SMITH

IPC: A61L27/52 ,  A61L27/54 ,  A61L27/38 ,  A61L27/36 ,  C12N5/0793 ,  A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/58 ,  A61L27/34

CPC classification number: A61L27/52 ,  A61K35/30 ,  A61L27/20 ,  A61L27/225 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/3675 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2420/00 ,  A61L2430/32 ,  C12N5/0619 ,  C12N2533/52 ,  C12N2533/56 ,  C12N2533/76 ,  C12N2533/78 ,  C12N2533/80 ,  C12N2533/90

Abstract: The present invention provides compositions and methods for modulation of neuronal networks in the CNS and/or PNS. In certain embodiments, the invention includes modulation of existing networks or restoring one or more damaged or lost axonal connections. In one embodiment, the invention comprises a tissue-engineered composition comprising an elongated tubular construct having at least one neuron and axon extending through the core of the construct.

Abstract translation: 本发明提供了调节CNS和/或PNS中神经元网络的组合物和方法。 在某些实施例中，本发明包括调制现有网络或恢复一个或多个损伤或丢失的轴突连接。 在一个实施方案中，本发明包括组织工程化组合物，其包含具有延伸穿过构建体的核心的至少一个神经元和轴突的细长管状构建体。