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    Copolymer mordant for photographic dyes and photographic element containing the same
    2.
    发明授权
    Copolymer mordant for photographic dyes and photographic element containing the same 失效
    用于照相染料的共聚物媒染剂和含有它们的摄影元素

    公开(公告)号：US4596756A

    公开(公告)日：1986-06-24

    申请号：US614596

    申请日：1984-05-29

    申请人： Junichi Yamanouchi ,  Yukio Sudo

    发明人： Junichi Yamanouchi ,  Yukio Sudo

    IPC分类号： C08F8/00 ,  C08F8/32 ,  G03C1/835 ,  G03C7/396 ,  G03C8/56 ,  G03C5/54 ,  C08F20/44

    CPC分类号： G03C1/835 ,  G03C7/396 ,  G03C8/56 ,  Y10S430/142

    摘要： A photographic element having at least one layer containing a copolymer mordant having the repeating unit represented by the following general formula (I) ##STR1## wherein A represents a monomer unit (copolymer component) derived from a copolymerizable monomer having at least two ethylenically unsaturated groups; B represents a monomer unit (copolymer unit) derived from a copolymerizable ethylenically unsaturated monomer represented by the following general formula (II) ##STR2## wherein R.sub.5 represents a hydrogen atom or an alkyl group; L represents an alkylene group or an arylene group; and m is 0 or 1; D represents a monomer unit (copolymer component) derived from a copolymerizable ethylenically unsaturated monomer other than the monomer units shown by A and B and the monomer unit having component ratio z; R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, each represents an alkyl group or an aralkyl group, and at least two of R.sub.2, R.sub.3 and R.sub.4 may combine to form a heterocyclic structure with a nitrogen atom; n represents an integer of from 1 to about 12; x.sup..crclbar. represents an anion; w represents 0 to about 10 mol %; x represents from about 5 to about 90 mol %; y represents from 0 to about 80 mol %; and z represents from about 10 to about 95 mol %.

    摘要翻译： 具有至少一层含有具有下述通式（I）所示的重复单元的共聚物媒染剂的照相元件，其中A表示由可共聚单体衍生的单体单元（共聚物组分），所述共聚单体具有至少两个 烯属不饱和基团; B表示由下述通式（II）表示的可共聚烯属不饱和单体衍生的单体单元（共聚单元），其中R 5表示氢原子或烷基; L表示亚烷基或亚芳基; m为0或1; D表示除了由A和B所示的单体单元以外的可共聚烯属不饱和单体和单体单元的组分比率z的单体单元（共聚物组分） R1表示氢原子或低级烷基; R 2，R 3和R 4可以相同或不同，各自表示烷基或芳烷基，R 2，R 3和R 4中的至少两个可以结合形成与氮原子的杂环结构; n表示1〜12的整数， x（ - ）表示阴离子; w表示0〜约10摩尔％ x表示约5至约90mol％; y表示0〜约80摩尔％。 z表示约10至约95mol％。

    Assay chip
    4.
    发明申请
    Assay chip 审中-公开
    测定芯片

    公开(公告)号：US20070178521A1

    公开(公告)日：2007-08-02

    申请号：US10592748

    申请日：2005-03-15

    申请人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe ,  Bo Yang

    发明人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe ,  Bo Yang

    IPC分类号： G01N33/53 ,  C12M3/00

    CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0409

    摘要： An integrated assay chip for assaying one or more components of a specimen, which comprises: (1) one or more pretreatment elements for pretreating a specimen; (2) one or more multilayer dry assay elements capable of assaying one or more components of the pretreated specimen; and (3) one or more flow channels connecting the pretreatment element and the multilayer dry assay element is provided.

    摘要翻译： 一种用于测定样品的一种或多种组分的综合测定芯片，其包括：（1）用于预处理样品的一种或多种预处理元件; （2）能够测定预处理样品的一种或多种组分的一种或多种多层干测定元件; 和（3）提供连接预处理元件和多层干测定元件的一个或多个流动通道。

    Microreactor
    5.
    发明申请
    Microreactor 审中-公开
    微反应器

    公开(公告)号：US20070141616A1

    公开(公告)日：2007-06-21

    申请号：US11657538

    申请日：2007-01-25

    申请人： Yukio Sudo

    发明人： Yukio Sudo

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/558

    摘要： The present invention provides a reactive microreactor wherein a group of the following formula (1) which can bind to a member of specifically binding partner, is bound to a part or entirety of a wall surface of a channel: -L-SO2—X1  (1) wherein X1 represents —CR1═CR2R3 or —CHR1—CR2R3Y; R1, R2 and R3 independently represent an atom or a group selected from the group consisting of a hydrogen atom, a C1-6 alkyl group, a C6-20 aryl group, and a C7-20 aralkyl group having a C1-6 alkyl chain; Y represents a group which can be substitutable by a nucleophilic reagent or a group which is released as “HY” by a base; and L represents a linking group. The microreactor according to the present invention has advantages that it requires a less amount of a reagent and achieves a higher S/N ratio.

    摘要翻译： 本发明提供了一种反应性微反应器，其中可结合特异性结合配偶体成员的下列通式（1）的基团与通道的壁表面的一部分或全部结合： 描述=“在线公式”end =“lead”？> - L-SO <2> <1> <1> <？in-line-formula description =“ 在线公式“end =”tail“？>其中X 1表示-CR 1 -CR 2 2 R 3， SUP>或-CHR 1 -CR 2 R 3 3 Y; R 1，R 2和R 3独立地表示选自以下的原子或基团：氢原子，C 1-6 烷基，C6-20芳基和具有C1-6烷基链的C7-20芳烷基; Y表示可以被亲核试剂或被基团释放为“HY”的基团取代的基团; L表示连接基团。 根据本发明的微反应器具有需要较少量的试剂并实现更高S / N比的优点。

    Analytical element for immunoassay and method for its preparation
    8.
    依法登记的发明
    Analytical element for immunoassay and method for its preparation 失效
    免疫测定的分析元素及其制备方法

    公开(公告)号：USH1664H

    公开(公告)日：1997-07-01

    申请号：US320771

    申请日：1989-03-08

    申请人： Yukio Sudo ,  Nobuhito Masuda

    发明人： Yukio Sudo ,  Nobuhito Masuda

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54386

    摘要： A dry-type analytical element for immunoassay utilizing antigen-antibody reaction in which the antigenic component is isolated from the antibody component by incorporating both components in separate layers or separately in a layer using different solvents. The analytical element is excellent in sensitivity and accuracy, and the analytical operation is simple.

    摘要翻译： 用于使用抗原 - 抗体反应进行免疫测定的干式分析元件，其中通过将两种组分并入分开的层中，或者使用不同溶剂在一层中分别地将抗原成分从抗体成分中分离出来。 分析元件的灵敏度和精度都很好，分析操作简单。

    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR
    10.
    发明申请
    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR 有权
    特异性识别转铁蛋白受体的抗体

    公开(公告)号：US20140114054A1

    公开(公告)日：2014-04-24

    申请号：US14116714

    申请日：2012-05-07

    申请人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    发明人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    IPC分类号： C07K16/30

    CPC分类号： C07K16/30 ,  C07K16/2881

    摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).

    摘要翻译： 本发明的目的是提供一种完全人抗TfR抗体，其特异性识别人TfR，抑制高表达TfR的癌细胞的存活或生长，并且对人类没有免疫原性。 本发明提供与人TfR特异性反应的抗体，其中所述抗体包含SEQ ID NO： 31-33,37-39,43-45,49-51,55-57,61-63,67-69,73-75,79-81,85-87,91-93,97-99,103- 105，109-111和115-117，作为重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3） 。