公开(公告)号：US20070178521A1

公开(公告)日：2007-08-02

申请号：US10592748

申请日：2005-03-15

申请人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe ,  Bo Yang

发明人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe ,  Bo Yang

IPC分类号： G01N33/53 ,  C12M3/00

CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0409

摘要： An integrated assay chip for assaying one or more components of a specimen, which comprises: (1) one or more pretreatment elements for pretreating a specimen; (2) one or more multilayer dry assay elements capable of assaying one or more components of the pretreated specimen; and (3) one or more flow channels connecting the pretreatment element and the multilayer dry assay element is provided.

摘要翻译： 一种用于测定样品的一种或多种组分的综合测定芯片，其包括：（1）用于预处理样品的一种或多种预处理元件; （2）能够测定预处理样品的一种或多种组分的一种或多种多层干测定元件; 和（3）提供连接预处理元件和多层干测定元件的一个或多个流动通道。

公开(公告)号：US20070178009A1

公开(公告)日：2007-08-02

申请号：US10592230

申请日：2005-03-15

申请人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Yukio Sudo

发明人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Yukio Sudo

IPC分类号： G01N21/00

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150274 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150389 ,  A61B2560/0223 ,  A61B2562/0295 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/75 ,  G01N31/22

摘要： An analysis element for use in a blood test method enabling easy and simple operations that are performed quickly up to measurement, an analysis element for use in a blood test method that operations up to the measurement for many components can be quickly performed, and that is safe and has a sufficient measurement accuracy thereof, and an analysis element for use in a test method using body fluids and urines of humans and animals, plain water, seawater, soil extract, agricultural products, marine products, processed-food extracts, and liquid for use in scientific research as specimens, are provided, the present invention relates to a multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an area sensor as a detector to obtain a result of measurement according to information represented by 1000 pixels or more per one component, and to perform simultaneous measurements of plural components.

摘要翻译： 一种用于血液检查方法的分析元件，其能够实现快速进行测量的简单且简单的操作，用于血液测试方法的分析元件可以快速执行多达成分测量的操作，也就是说 安全且具有足够的测量精度，以及用于使用人体和动物，普通水，海水，土壤提取物，农产品，海产品，加工食品提取物和液体的体液和尿液的测试方法中的分析元件 本发明涉及一种用于试样检测方法的多组分测量干燥分析元件，该方法使用区域传感器作为检测器，以获得测量结果 对于每个分量由1000个像素或更多个表示的信息，并且执行多个分量的同时测量。

公开(公告)号：US20060068491A1

公开(公告)日：2006-03-30

申请号：US11227245

申请日：2005-09-16

申请人： Yoshihiko Makino ,  Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

发明人： Yoshihiko Makino ,  Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

IPC分类号： C12M1/34 ,  C07H21/04

CPC分类号： B01L3/502753 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/0631 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0487

摘要： A microdevice for performing a method for separating and purifying a nucleic acid, the microdevice comprising: at least one opening; and at least one channel for passing a sample solution, wherein the method comprises: (A) a step of bringing a nucleic acid-containing sample solution into contact with a nucleic acid-adsorbing support having a function of adsorbing a nucleic acid; (B) a step of washing the nucleic acid-adsorbing support with a washing solution in a state of a nucleic acid being adsorbed to the support; and (C) a step of desorbing the nucleic acid from the nucleic acid-adsorbing support by a recovering solution, thereby purifying the nucleic acid; an apparatus for utilizing the microdevice; and a reagent kit for use in the microdevice.

摘要翻译： 一种用于进行分离和纯化核酸的方法的微型装置，所述微型装置包括：至少一个开口; 和用于通过样品溶液的至少一个通道，其中所述方法包括：（A）使含核酸样品溶液与具有吸附核酸功能的核酸吸附载体接触的步骤; （B）在被吸附在所述载体上的核酸的状态下用洗涤液洗涤所述核酸吸附载体的工序; 和（C）通过回收溶液从核酸吸附载体解吸核酸的步骤，从而纯化核酸; 一种利用微型装置的装置; 和用于微型装置的试剂盒。

公开(公告)号：US20050202569A1

公开(公告)日：2005-09-15

申请号：US11075434

申请日：2005-03-09

申请人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

发明人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

IPC分类号： G01N31/20 ,  G01N33/00 ,  G01N33/52 ,  G01N37/00

CPC分类号： G01N33/525

摘要： A microchemical device capable of promoting mixing of a specimen and a reagent particularly in analyzing trace constituents of liquid such as blood or body fluid, and a microchemical device that can rapidly and easily analyze one or more constituents from a small amount of specimen, are provided, which is an integrated microchemical device for analyzing one or more constituents of a specimen, the microchemical device comprising at least the two elements of (a) one or more flow channels through which a specimen passes and (b) a multilayer dry analysis element that can come in contact with at least one of the flow channels and analyze the constituents of the specimen.

摘要翻译： 提供能够促进样品和试剂混合的微化学装置，特别是在分析液体，如血液或体液的微量成分的微量化学装置中，以及能够从少量样品快速，容易地分析一种或多种成分的微化学装置 ，其是用于分析样品的一种或多种成分的集成微量化学装置，所述微化学装置至少包括（a）样品通过的一个或多个流动通道的两个元件和（b）多层干燥分析元件， 可以与至少一个流动通道接触并分析试样的组分。

公开(公告)号：US20050002038A1

公开(公告)日：2005-01-06

申请号：US10849777

申请日：2004-05-21

申请人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

发明人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

IPC分类号： G01N21/01 ,  G01N21/27 ,  G01N21/31 ,  G01N21/47 ,  G01N21/59 ,  G01N21/86

CPC分类号： G01N21/8483 ,  G01N21/31 ,  G01N21/4738

摘要： An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.

摘要翻译： 光学测量装置包括：用第一光照亮第一物体的照明部分; 光改变部，其改变照射第一物体的第一光的强度; 光接收装置，其接收透过或者从第一物体反射的第二光; 以及输出部，其根据i）光改变部的状态输出测量结果，以及ii）由光接收装置接收的第二光的量。 另外，光学测量装置包括：照明部; 光接收装置; 光接收时间改变部，其改变所述光接收装置的光接收时间; 以及输出部，其根据i）光接收时间输出测量结果，以及ii）由光接收装置接收的第二光的量。

公开(公告)号：US07369243B2

公开(公告)日：2008-05-06

申请号：US10849777

申请日：2004-05-21

申请人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

发明人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

IPC分类号： G01N21/47

CPC分类号： G01N21/8483 ,  G01N21/31 ,  G01N21/4738

摘要： An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.

摘要翻译： 光学测量装置包括：用第一光照亮第一物体的照明部分; 光改变部，其改变照射第一物体的第一光的强度; 光接收装置，其接收透过或者从第一物体反射的第二光; 以及输出部，其根据i）光改变部的状态输出测量结果，以及ii）由光接收装置接收的第二光的量。 另外，光学测量装置包括：照明部; 光接收装置; 光接收时间改变部，其改变所述光接收装置的光接收时间; 以及输出部，其根据i）光接收时间输出测量结果，以及ii）由光接收装置接收的第二光的量。

公开(公告)号：US20070219509A1

公开(公告)日：2007-09-20

申请号：US11717689

申请日：2007-03-14

申请人： Tomoko Tashiro ,  Yoshiki Sakaino ,  Yoshihiko Abe

发明人： Tomoko Tashiro ,  Yoshiki Sakaino ,  Yoshihiko Abe

IPC分类号： A61M5/32

CPC分类号： A61B5/1545 ,  A61B5/15003 ,  A61B5/150396 ,  A61B5/150473 ,  A61B5/150572 ,  A61B5/150717 ,  A61B5/150732 ,  A61B5/15074

摘要： A blood collecting needle, which comprises: a needle tube having a human-body puncturing needle tube and a stopper-body puncturing needle tube, wherein the needle tube has an outer diameter having substantially the same dimension from a tip of the human-body puncturing needle tube to a tip of the stopper-body puncturing needle tube, the needle tube has an inner diameter having substantially the same dimension from the tip of the human-body puncturing needle tube to the tip of the stopper-body puncturing needle tube, and the blood collecting needle satisfies equation (1): 0.35≦D1

摘要翻译： 一种采血针，其特征在于，包括：针管，其具有人体穿刺针管和塞体穿刺针管，其中，所述针管的外径与所述人体穿刺的前端具有大致相同的尺寸 针管到塞体穿刺针管的尖端，针管具有从人体穿刺针管的尖端到塞体穿刺针管的前端具有大致相同尺寸的内径，以及 采血针满足式（1）：<？in-line-formula description =“In-line formula”end =“lead”？> 0.35 <= D <1> <0.70（等式1） <？in-line-formula description =“In-line formula”end =“tail”？>其中D <1>表示针管的外径（mm）。

公开(公告)号：US20070149944A1

公开(公告)日：2007-06-28

申请号：US11634839

申请日：2006-12-07

申请人： Tomoko Tashiro ,  Yoshiki Sakaino ,  Yoshihiko Abe

发明人： Tomoko Tashiro ,  Yoshiki Sakaino ,  Yoshihiko Abe

IPC分类号： A61M5/32

CPC分类号： A61B5/150488 ,  A61B5/15003 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150572 ,  A61B5/150717 ,  A61B5/150732 ,  A61B5/1545 ,  A61M5/3286 ,  A61M5/329

摘要： A blood collecting needle, which comprises: a needle hub; a human-body puncturing needle tube provided at one side of the needle hub; and a plug-body puncturing needle tube provided at the other side of the needle hub, wherein an outer diameter of a tip of the human-body puncturing needle tube and an outer diameter of a tip of the plug-body puncturing needle tube are different from each other.

摘要翻译： 一种采血针，其特征在于，包括：针座; 设置在针座的一侧的人体穿刺针管; 以及设置在针座的另一侧的插头体穿刺针管，其中，人体穿刺针管的前端的外径和插塞体穿刺针管的前端的外径不同 从彼此。

公开(公告)号：US5972635A

公开(公告)日：1999-10-26

申请号：US158485

申请日：1998-09-22

申请人： Hideaki Tanaka ,  Yoshihiko Abe ,  Yoshiki Sakaino ,  Kaoru Terashima

发明人： Hideaki Tanaka ,  Yoshihiko Abe ,  Yoshiki Sakaino ,  Kaoru Terashima

IPC分类号： C12Q1/32 ,  C12Q1/48 ,  C12Q1/50 ,  G01N33/52 ,  G01N33/70

CPC分类号： G01N33/70 ,  C12Q1/50

摘要： A dry analytical element for quantitatively analyzing creatine kinase is composed of a support and a creatine kinase-detecting agent layer. The creatine kinase-detecting agent layer contains creatine phosphate and adenosine diphosphate which react with each other to give adenosine triphosphate in the presence of creatine kinase, a buffer compound having a sulfonic acid group which keeps the layer in the range of pH 5.5 to pH 8.5 for the formation of adenosine triphosphate, and an indicator composition which reacts with the formed adenosine triphosphate to give a spectroscopically detectable compound. An analytical element for analysis of creatine kinase MB isozyme further contains in the layer an antibody which specifically inhibits activity of M sub-unit of creatine kinase.

摘要翻译： 用于定量分析肌酸激酶的干燥分析元件由载体和肌酸激酶检测剂层组成。 肌酸激酶检测剂层含有磷酸肌酸和二磷酸腺苷，其在肌酸激酶存在下相互反应以产生腺苷三磷酸，其是具有磺酸基的缓冲化合物，其将该层保持在pH5.5至pH8.5的范围内 用于形成三磷酸腺苷，以及与形成的三磷酸腺苷反应以产生光谱可检测化合物的指示剂组合物。 用于分析肌酸激酶MB同功酶的分析元素在该层中进一步含有特异性抑制肌酸激酶M亚单位活性的抗体。

公开(公告)号：US07737214B2

公开(公告)日：2010-06-15

申请号：US10592956

申请日：2005-03-11

申请人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

发明人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

IPC分类号： C08B31/00 ,  C08B37/00 ,  A01N43/04 ,  A61K31/715

CPC分类号： A61L31/042 ,  A61K31/715 ,  C08B31/02 ,  C08B37/0012 ,  C08B37/0018 ,  C08B37/0021

摘要： An adhesion preventive material including a cross-linking polysaccharide derivative containing at least one active ester group introduced in a polysaccharide side chain, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked material due to covalent binding among the active ester group and an active hydrogen-containing group upon contact with water under an alkaline condition, is disclosed. The adhesion preventive material is able to reduce preparation works to be carried out while previously estimating the time of application and does not require a special device.

摘要翻译： 一种防粘连材料，包括含有至少一种引入多糖侧链的活性酯基的交联多糖衍生物，其能够与含活性氢基团反应，并且能够由于共价结合而形成交联材料 在碱性条件下与水接触时，活性酯基和活性含氢基团中。 防粘连材料能够在以前估计施用时间的情况下减少要进行的准备工作，并且不需要特殊装置。