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    Method for extracting pullulan polysaccharide from high-viscosity fermentation broth
    1.
    发明授权
    Method for extracting pullulan polysaccharide from high-viscosity fermentation broth 有权

    公开(公告)号：US12122855B2

    公开(公告)日：2024-10-22

    申请号：US18627748

    申请日：2024-04-05

    申请人： TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY

    发明人： Changsheng Qiao ,  Ganggang Cheng ,  Liang Lu ,  Tingbin Zhao ,  Zhenhai Li

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0003 ,  C08B37/0018

    摘要： A method for extracting pullulan polysaccharide from high-viscosity fermentation broth includes following steps: (1) removing cells from the fermentation broth; (2) removing proteins; (3) decolorizing by macroporous resin adsorption; (4) removing ions by ultrafiltration; and (5) drying, crushing and packaging. In the extraction method of the present application, by using natural polymer bioflocculant chitosan, the high-viscosity fermentation broth can be processed without dilution and addition of filter aids and organic solvents for alcohol precipitation, which reduces the pressure of subsequent decolorization, properly recycles the cell proteins, and avoids the potential hazard of the organic solvents. The method can obtain high-purity pullulan polysaccharide, improving the product yield and quality, reducing solid waste, reducing the production cost, and achieving a safe, efficient, continuous and automated production process.

    CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM
    2.
    发明申请
    CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM 审中-公开
    交联金属多糖衍生物及其制备方法

    公开(公告)号：US20160215068A1

    公开(公告)日：2016-07-28

    申请号：US15025451

    申请日：2014-09-26

    申请人： Kevin J. EDGAR ,  Xiangtao MENG ,  John MATSON

    发明人： Kevin J. Edgar ,  Xiangtao Meng ,  John Matson

    IPC分类号： C08B3/16 ,  C08B3/14 ,  A61K47/38

    CPC分类号： C08B3/16 ,  A61K47/38 ,  C08B3/00 ,  C08B3/14 ,  C08B37/0018 ,  C08B37/0021

    摘要： Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose co-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

    摘要翻译： 描述了多糖与一种或多种烯烃封端的侧链和交叉复合产物的交叉复分解方法。 在一个示例性实施方案中，描述了通过烯烃交叉复分解合成纤维素共 - 羧酸酯的方法。 反应条件相对温和，烯烃取代的多糖和适当的单体烯烃合成物似乎遵循本文总结的Grubbs规则。 化合物和方法可用于结构性质研究，特别是那些旨在开发用于药物递送的聚合物的那些，例如用于控制释放药物递送系统，控释包衣，药物的增加的生物利用度和维持GI中的药物过饱和度 道。

    Adhesion preventive material
    10.
    发明授权
    Adhesion preventive material 有权
    防粘连材料

    公开(公告)号：US07737214B2

    公开(公告)日：2010-06-15

    申请号：US10592956

    申请日：2005-03-11

    申请人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

    发明人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

    IPC分类号： C08B31/00 ,  C08B37/00 ,  A01N43/04 ,  A61K31/715

    CPC分类号： A61L31/042 ,  A61K31/715 ,  C08B31/02 ,  C08B37/0012 ,  C08B37/0018 ,  C08B37/0021

    摘要： An adhesion preventive material including a cross-linking polysaccharide derivative containing at least one active ester group introduced in a polysaccharide side chain, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked material due to covalent binding among the active ester group and an active hydrogen-containing group upon contact with water under an alkaline condition, is disclosed. The adhesion preventive material is able to reduce preparation works to be carried out while previously estimating the time of application and does not require a special device.

    摘要翻译： 一种防粘连材料，包括含有至少一种引入多糖侧链的活性酯基的交联多糖衍生物，其能够与含活性氢基团反应，并且能够由于共价结合而形成交联材料 在碱性条件下与水接触时，活性酯基和活性含氢基团中。 防粘连材料能够在以前估计施用时间的情况下减少要进行的准备工作，并且不需要特殊装置。