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    Functionalized oligosaccharides
    1.
    发明申请
    Functionalized oligosaccharides 有权
    官能化寡糖

    公开(公告)号：US20120309680A1

    公开(公告)日：2012-12-06

    申请号：US13468849

    申请日：2012-05-10

    申请人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    发明人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    IPC分类号： C08B37/02 ,  A61K38/18

    CPC分类号： A61K38/28 ,  A61K47/61 ,  C08B37/0021

    摘要： The invention relates to an oligodextran, chosen from dextrans whose average degree of polymerization is less than 10, modified by at least one substituent of general formula I: —R1-[[AA]-[R2]n]m  formula I It also relates to a pharmaceutical composition characterized in that it comprises an oligosaccharide according to the invention and an active ingredient is chosen from the group consisting of proteins, glycoproteins, peptides and non-peptide therapeutic molecules.

    摘要翻译： 本发明涉及一种选自平均聚合度小于10的葡聚糖的寡葡聚糖，其通过通式I至少一个取代基修饰：-R1 - [[AA] - [R2] n] m式I还涉及 涉及一种药物组合物，其特征在于其包含根据本发明的寡糖，活性成分选自蛋白质，糖蛋白，肽和非肽治疗分子。

    Polyglutamic acids functionalised by histidine derivatives and hydrophobic groups and the uses thereof, in particular for therapeutic purposes
    2.
    发明授权
    Polyglutamic acids functionalised by histidine derivatives and hydrophobic groups and the uses thereof, in particular for therapeutic purposes 失效
    由组氨酸衍生物和疏水基团官能化的聚谷氨酸及其用途，特别是用于治疗目的

    公开(公告)号：US08293255B2

    公开(公告)日：2012-10-23

    申请号：US12084368

    申请日：2006-10-31

    申请人： Olivier Soula ,  Rémi Soula ,  Olivier Breyne

    发明人： Olivier Soula ,  Rémi Soula ,  Olivier Breyne

    IPC分类号： A61K9/10 ,  A61K9/16 ,  A61K9/00 ,  A61K47/32 ,  A61K47/00

    CPC分类号： C08G69/10 ,  A61K8/88 ,  A61K2800/57 ,  A61Q19/00 ,  C07K14/001

    摘要： The invention relates to novel biodegradable materials based on modified polyamino acids and suitable, in particular, for vectoring active substance(s) (AS). Said invention also relates to novel pharmaceutical, cosmetic, dietary or plant protective compositions which are based on said polyamino acids.The aim of said invention is to provide a novel polymer raw material usable for vectoring the AS and capable to optimally meet all specification in this area: biocompatibility, biodegradability, ability to become easily associated with many active substances or to solubilize them and to release said active substances in vivo. The aim is attained to 30 carbon atoms.Said polyglutamates modified by histidine derivatives are soluble with pH lower than 5 and are easily and economically convertible into active substance vectorization particles which are able to form stable aqueous colloidal suspensions. On the contrary, said modified polyglutamates are insoluble in water with a physiological pH (7.4), and thereby have to be precipitated on an injection site in the case of a subcutaneous injection.

    摘要翻译： 本发明涉及基于改性聚氨基酸的新型可生物降解材料，特别适用于载体活​​性物质（AS）。 所述发明还涉及基于所述聚氨基酸的新型药物，化妆品，膳食或植物保护性组合物。 本发明的目的是提供一种可用于载体AS的新型聚合物原料，能够最佳地满足该领域的所有规格：生物相容性，生物降解性，与许多活性物质容易相关的能力或使其溶解并释放所述 体内活性物质。 目标达到30个碳原子。 由组氨酸衍生物修饰的所述聚谷氨酸可溶于pH低于5，易于经济地转化成能形成稳定的水性胶体悬浮液的活性物质载体化颗粒。 相反，所述改性的聚谷氨酸不溶于具有生理pH（7.4）的水中，因此在皮下注射的情况下必须在注射部位沉淀。

    DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS
    3.
    发明申请
    DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS 审中-公开
    由疏水性氨基酸功能化的地西泮

    公开(公告)号：US20120041079A1

    公开(公告)日：2012-02-16

    申请号：US13250803

    申请日：2011-09-30

    申请人： Gerard SOULA ,  Olivier Soula ,  Remi Soula ,  Richard Charvet

    发明人： Gerard SOULA ,  Olivier Soula ,  Remi Soula ,  Richard Charvet

    IPC分类号： A61K47/36 ,  C07H15/18 ,  C07H15/04 ,  C07H17/02

    CPC分类号： A61K31/721 ,  A61K47/36 ,  C08B37/0021

    摘要： Dextran of the following general formula I: is described, wherein R represents a chain containing from 1 to 15 carbon atoms and having at least one acid functional group prior to attachment to AA, the chain optionally being branched and/or unsaturated and containing one or more heteroatoms, such as O, N or/and S, F represents an ester, a carbamate or an ether, AA represents a hydrophobic amino acid radical, L or D, derived from a coupling between an amine of an amino acid and at least one acid functional group of R; the amino acid, prior to attachment to R, being selected from the group consisting of tryptophan, phenylalanine, leucine, isoleucine, alanine and valine, and alcohol, amide or decarboxylated derivatives thereof, and alkaline cation salts thereof, i represents the molar fraction of substituent F—R-[AA]n per glycosidic unit and is from 0.1 to 2, n represents the molar fraction of R groups substituted by AA and is from 0.05 to 1, and wherein for R groups not substituted by AA, the acid(s) of the group R are alkaline cation carboxylates such as Na or K.

    摘要翻译： 描述了以下通式I的葡聚糖，其中R表示含有1至15个碳原子并且在与AA连接之前具有至少一个酸官能团的链，该链任选是支链和/或不饱和的，并且含有一个或 更多的杂原子，例如O，N或/和S，F代表酯，氨基甲酸酯或醚，AA代表疏水性氨基酸基团，L或D衍生自氨基酸的胺与至少 一个酸官能团的R; 氨基酸在与R连接之前选自色氨酸，苯丙氨酸，亮氨酸，异亮氨酸，丙氨酸和缬氨酸，以及其醇，酰胺或其脱羧基衍生物及其碱性阳离子盐，i表示 取代基F-R- [AA] n，为0.1〜2，n表示被AA取代的R基的摩尔分数，为0.05〜1，对于不被AA取代的R基，酸（ 的基团R是碱性阳离子羧酸盐，例如Na或K.

    Complex consisted of a polysaccharide and an HBP
    7.
    发明申请
    Complex consisted of a polysaccharide and an HBP 有权
    复合物由多糖和HBP组成

    公开(公告)号：US20100184965A1

    公开(公告)日：2010-07-22

    申请号：US12585886

    申请日：2009-09-28

    申请人： Olivier Soula ,  Remi Soula ,  Martin Gaudier ,  Gerard Soula

    发明人： Olivier Soula ,  Remi Soula ,  Martin Gaudier ,  Gerard Soula

    IPC分类号： A61K47/48 ,  C08B37/04 ,  C08B15/06 ,  C08B37/00

    CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K38/1825 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/27 ,  A61K38/29 ,  A61K47/42 ,  A61K47/61

    摘要： The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.

    摘要翻译： 本发明涉及由多糖和HBP组成的复合物，所述多糖由（1,6）和/或（1,4）和/或（1,3）和/或（1,2）的糖苷键组成 ）类型并用至少一种可成盐或盐化的色氨酸衍生物官能化。 本发明还涉及包含根据本发明的复合物和由（1,6）和/或（1,4）和/或（1,3）和/或（1,3）的糖苷键组成的多糖和/ 或（1,2）型，并用至少一种可成盐或盐化的色氨酸衍生物官能化，用于制备稳定HBP的药物制剂。

    Angiogenic composition
    9.
    发明申请
    Angiogenic composition 审中-公开
    血管生成成分

    公开(公告)号：US20080293635A1

    公开(公告)日：2008-11-27

    申请号：US12078443

    申请日：2008-03-31

    申请人： Olivier Soula ,  Gerard Soula ,  Remi Soula ,  Rosy Eloy

    发明人： Olivier Soula ,  Gerard Soula ,  Remi Soula ,  Rosy Eloy

    IPC分类号： A61K38/16 ,  A61P9/00

    CPC分类号： A61K9/0014 ,  A61K38/1858 ,  A61K47/61

    摘要： The present invention relates to a amphiphilic polymer in the preparation of a therapeutic composition for promoting angiogenesis at its site of administration, comprising a complex between a polymer and a PDGF, wherein the polymer is amphiphilic.In an embodiment, the PDGF is selected from the group of the PDGFs (platelet-derived growth factors) and the amphiphilic polymer is selected from the group: The invention relates also to the therapeutic composition is in the form of a gel, a cream, a solution, a spray, a paste or a patch or a dressing.

    摘要翻译： 本发明涉及制备用于在其施用部位促进血管发生的治疗组合物的两亲性聚合物，其包含聚合物和PDGF之间的复合物，其中所述聚合物是两亲性的。 在一个实施方案中，PDGF选自PDGF（血小板衍生生长因子）组，两亲性聚合物选自：本发明还涉及治疗组合物，其形式为凝胶，霜剂， 溶液，喷雾剂，糊剂或贴剂或敷料。

    Process and compositions promoting biological effectiveness of exogenous chemical substances in plants
    10.
    发明授权
    Process and compositions promoting biological effectiveness of exogenous chemical substances in plants 失效
    促进植物中外源化学物质生物有效性的方法和成分

    公开(公告)号：US6133199A

    公开(公告)日：2000-10-17

    申请号：US124318

    申请日：1998-07-29

    申请人： Gerard G. Soula ,  Remi Meyrueix ,  Alain J. L. Lemercier ,  Nathan J. Bryson ,  Olivier Soula ,  Anthony J. I. Ward ,  Jane L. Gillespie ,  Ronald J. Brinker

    发明人： Gerard G. Soula ,  Remi Meyrueix ,  Alain J. L. Lemercier ,  Nathan J. Bryson ,  Olivier Soula ,  Anthony J. I. Ward ,  Jane L. Gillespie ,  Ronald J. Brinker

    IPC分类号： A01N25/04 ,  A01N25/30 ,  A01N57/20 ,  C07F9/38

    CPC分类号： C07F9/3813 ,  A01N25/04 ,  A01N25/30 ,  A01N57/20

    摘要： A plant treatment composition for application of an anionic exogenous chemical substance such as glyphosate herbicide to foliage of a plant is provided. The composition is a colloidal dispersion having supramolecular aggregates dispersed in an aqueous application medium. The supramolecular aggregates comprise one or more amphiphilic salt(s) having anions of the exogenous chemical substance and cations derived by protonation of one or more polyamine(s) or polyamine derivative(s) each having (a) at least two nitrogen-containing groups, of which a number n not less than 1 are amino groups that can be protonated to form cationic primary, secondary or tertiary ammonium groups, and (b) at least one hydrocarbyl or acyl group having about 6 to about 30 carbon atoms. The composition contains (i) a molar amount X in total of the exogenous chemical substance, in all salt and acid forms thereof present, sufficient to elicit a biological response when the composition is applied to the foliage of the plant at a rate of about 10 to about 1000 l/ha, (ii) a molar amount A in total of said polyamine(s) and derivative(s) thereof and cations derived therefrom, and (iii) a zero or molar amount B in total of one or more monovalent base(s) and cations derived therefrom, said base(s) being other than a polyamine or derivative thereof, such that nA/(nA+B) is about 0.01 to 1, and (nA+B)/X is about 0.5 to about 10.Also provided are a liquid concentrate composition which, upon dilution with water, forms a plant treatment composition as described above, and a process for making such a liquid concentrate composition. Plant treatment compositions of the invention are useful for eliciting a biological activity, for example herbicidal activity, in a plant when applied to foliage thereof.

    摘要翻译： 提供了一种用于将阴离子外源化学物质如草甘膦除草剂施用于植物叶子的植物处理组合物。 该组合物是具有分散在水溶液介质中的超分子聚集体的胶态分散体。 超分子聚集体包含一种或多种具有外源化学物质的阴离子的两亲盐和通过一种或多种多胺或多胺衍生物的质子化产生的阳离子，每个多胺或多胺衍生物各自具有（a）至少两个含氮基团 其数n为不小于1的氨基可以被质子化形成阳离子伯，仲或叔铵基团，和（b）至少一个具有约6至约30个碳原子的烃基或酰基。 所述组合物包含（i）外源化学物质的总量X，其存在的所有盐和酸形式，足以引起组合物以约10的速率施用于植物的叶子时的生物反应 至约1000l / ha，（ii）所述多胺及其衍生物的总摩尔量A和由其衍生的阳离子，和（iii）零或摩尔量B总计为一种或多种一价 碱和其衍生的阳离子，所述碱不是多胺或其衍生物，使得nA /（nA + B）为约0.01至1，和（nA + B）/ X为约0.5至 还提供了液体浓缩组合物，其在用水稀释时形成如上所述的植物处理组合物，以及制备这种液体浓缩组合物的方法。 本发明的植物处理组合物可用于在施用于其叶面时在植物中引发生物活性，例如除草活性。