公开(公告)号：US11707528B2

公开(公告)日：2023-07-25

申请号：US17559620

申请日：2021-12-22

申请人： Shenzhen Rhegen Biotechnology Co., Ltd.

发明人： Yong Hu ,  Miaomiao Zhang

IPC分类号： A61K47/54 ,  A61K39/385 ,  C07H5/00 ,  C07H5/06 ,  A61K39/00

CPC分类号： A61K47/549 ,  A61K39/385 ,  C07H5/00 ,  C07H5/06 ,  A61K2039/53

摘要： The present invention provides a mannose-based mRNA targeted delivery system and use thereof. The mRNA can encode one or more target polypeptides and contains at least one mannose modification. The technical solution of the present invention modifies the mRNA molecule with a mannose, so that the mRNA can be directly and efficiently coupled with the mannose, and the targeted delivery of the mRNA is realized without the need for a carrier.

公开(公告)号：US10214765B2

公开(公告)日：2019-02-26

申请号：US15881581

申请日：2018-01-26

申请人： Academina Sinica

发明人： Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun E. Cheng ,  Chamg-Sheng Tsai

IPC分类号： C07H5/00 ,  C07H13/04 ,  C07H13/12 ,  C12N9/24 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q1/40 ,  C12Q1/70

摘要： Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.

公开(公告)号：US20090318381A1

公开(公告)日：2009-12-24

申请号：US12310988

申请日：2007-09-14

申请人： Bahram Memarzadeh

发明人： Bahram Memarzadeh

IPC分类号： A61K31/7016 ,  C07H5/00 ,  A61K31/702

CPC分类号： C07H3/04 ,  A61K31/715 ,  C07H3/06

摘要： The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.

摘要翻译： 本发明涉及一种新颖的烷基化卤代二糖和三糖家族，其在渗透促进剂，抗微生物作用，抗散逸作用，促进诊断程序方面表现出药物功效。 本发明还包括治疗和诊断试剂盒的方法。

公开(公告)号：US06927289B2

公开(公告)日：2005-08-09

申请号：US10694352

申请日：2003-10-28

申请人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C08B37/00 ,  C07H5/00

CPC分类号： C08B37/006

摘要： A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

摘要翻译： 通过使来自属于层状藻酸盐的藻类的新型硫酸化多糖消化的硫酸化的岩藻糖消化酶作用于硫酸化的岩藻石上的小分子及其制造方法。

公开(公告)号：US4267314A

公开(公告)日：1981-05-12

申请号：US11133

申请日：1979-02-12

申请人： Jean-Pierre Sachetto ,  Alain Regnault ,  Sergio Cuccolo ,  Herve Tournier ,  Jean-Michel Armanet

发明人： Jean-Pierre Sachetto ,  Alain Regnault ,  Sergio Cuccolo ,  Herve Tournier ,  Jean-Michel Armanet

IPC分类号： A23K50/15 ,  C07H13/12 ,  C07H5/00

CPC分类号： C07H13/12 ,  A23K50/15

摘要： A process for the preparation of lactosylurea and the N-methylol derivative thereof which are usable as feed supplements for ruminants.According to this process, lactose and urea are heated to 70.degree.-110.degree. C. with a minimum of water and, if possible, this water is eliminated during the reaction. The crude reaction product can be purified by grinding with ice-water or ethanol and subsequent draining so as to eliminate by dissolution in such solvants the unreacted urea.The corresponding N-methylol derivative is obtained by the reaction with formaldehyde.

摘要翻译： 一种制备可用作反刍动物饲料添加剂的乳糖基脲及其N-羟甲基衍生物的方法。 根据该方法，用最少量的水将乳糖和尿素加热至70-110℃，如果可能的话，在反应期间将其除去。 粗反应产物可以通过用冰水或乙醇研磨并随后排出来纯化，以便通过在这样的溶剂中溶解未反应的尿来消除。 通过与甲醛的反应获得相应的N-羟甲基衍生物。

公开(公告)号：US20090253117A1

公开(公告)日：2009-10-08

申请号：US12403790

申请日：2009-03-13

申请人： Blas Cerda ,  Mark Norman Bobrow

发明人： Blas Cerda ,  Mark Norman Bobrow

IPC分类号： C12Q1/25 ,  C07H1/00 ,  C07H5/00 ,  C08B37/00

CPC分类号： C12Q1/34 ,  C07C237/22 ,  C07H15/203 ,  C07K5/06 ,  C07K19/00 ,  G01N2333/924 ,  G01N2458/15

摘要： An inventive substrate is provided which includes a substrate compound of formula A-B1-B2-B3-B4: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 is a linker moiety with a free reactive amino group so as to be available for reaction with carboxylic acids or detectable tags; B3 contains a permanently charged element such as a quaternary ammonium group so as to increase sensitivity for mass spectrometry analysis; and B4 of various carbon length conferring specificity amongst individual substrates in detection methods. Also provided is a molecule of the formula B1-B2-B3-B4, with similar structural characteristics to an enzymatic product produced by the action of a target enzyme on an inventive substrate. Further provided are methods for using inventive substrates for detecting enzymatic activity.

摘要翻译： 提供了本发明的底物，其包括式A-B1-B2-B3-B4的底物化合物：其中A是糖部分; B1是连接部分，允许部分A与底物的剩余结构共轭; B2是具有游离反应性氨基的接头部分，以便可用于与羧酸或可检测标签反应; B3含有永久带电元件如季铵基，以提高质谱分析的灵敏度; 和各种碳长度的B4在检测方法中在各个底物之间赋予特异性。 还提供了式B1-B2-B3-B4的分子，其与通过靶酶在本发明底物上的作用产生的酶产物具有相似的结构特征。 还提供了使用本发明的底物检测酶活性的方法。

公开(公告)号：US07268207B2

公开(公告)日：2007-09-11

申请号：US09824787

申请日：2001-04-04

申请人： Maurice Zauderer ,  Elizabeth E. Evans ,  Melinda A. Borrello

发明人： Maurice Zauderer ,  Elizabeth E. Evans ,  Melinda A. Borrello

IPC分类号： A61K38/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07H5/00 ,  C07H21/02 ,  C07H21/00 ,  C08B37/00 ,  C08B37/08

CPC分类号： C07K14/47

摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptides, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.

摘要翻译： 本发明涉及在人癌中差异表达的新型人基因。 更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。 本发明还涉及C35多肽，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。 本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。 本发明还涉及C35基因和多肽在免疫原性组合物或疫苗中的配制和用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或细胞介导的免疫。 本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20070160526A1

公开(公告)日：2007-07-12

申请号：US10548718

申请日：2004-03-10

申请人： James Bruce ,  Sotiris Missailidis ,  Katalin Borbas ,  Catia Ferreira

发明人： James Bruce ,  Sotiris Missailidis ,  Katalin Borbas ,  Catia Ferreira

IPC分类号： A61K51/00 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/47 ,  A61K48/00 ,  C40B40/08 ,  C07D487/22 ,  C07H5/00 ,  C07F13/00 ,  C07F5/00

CPC分类号： G01N33/57484 ,  A61K31/197 ,  A61K31/395 ,  A61K31/409 ,  A61K31/555 ,  A61K31/70 ,  A61K31/7088 ,  A61K51/0491 ,  C07H21/00 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2310/3517 ,  G01N2333/4725 ,  A61K2300/00

摘要： There are disclosed aptamer ligands to MUC1, preferably comprising a sequence selected from:  1CGAATGGGCCCGTCCTCGCTGTAAG  2GCAACAGGGTATCCAAAGGATCAAA  3GTTCGACAGGAGGCTCACAACAGGC  4TGTTGGTCAGGCGGCGGCTCTACAT  5CTCTGTTCTTATTTGCGAGTTXXXX  6XCTCTGTTCTTATTTGCGAGTTXXX  7XXCTCTGTTCTTATTTGCGAGTTXX  8XXXCTCTGTTCTTATTTGCGAGTTX  9XXXXCTCTGTTCTTATTTGCGAGTT 10CTCTGTTCTTATTTGCGAGTT 11CCCTCTGTTCTTATTTGCGAGTTCA 12CTCTGTTCTTATTTGCGAGTTGGTG 13CCCTCTGTTCTTATTTGCGAGTTCA 14TAAGAACAGGGCGTCGTGTTACGAG 15GTGGCTTACTGCGAGGACGGGCCCA 16GCAGTTGATCCTTTGGATACCCTGG 17AACCCTATCCACTTTTCGGCTCGGG 18CGATTTAGTCTCTGTCTCTAGGGGT 19CGACAGGAGGCTCACAACAGGCAAC 20AGAACGAAGCGTTCGACAGGAGGCT 21AGAAACACTTGGTATATCGCAGATA 22GGGAGACAAGAATAAACACTCAACG and compounds comprising these aptamers and sequences. There are also disclosed compounds having the structure formula (I) and (II). There are also disclosed methods of treatment, diagnosis, detection and imaging using these compounds, their use in such methods, and their use in the preparation of medicaments and products for such methods.

公开(公告)号：US6075135A

公开(公告)日：2000-06-13

申请号：US282200

申请日：1999-03-31

申请人： Tomio Takeuchi ,  Sumio Umezawa ,  Tsutomu Tsuchiya ,  Yasushi Takagi

发明人： Tomio Takeuchi ,  Sumio Umezawa ,  Tsutomu Tsuchiya ,  Yasushi Takagi

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/244 ,  C07H15/252 ,  C07H1/00 ,  C07H5/00

CPC分类号： C07H15/252 ,  C07H15/244 ,  Y02P20/55

摘要： 7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-.alpha.-L-mannopyranosyl)-daunomycinone or -adriamycinone is now synthesized as a daunomycinone or adriamycinone derivative having the general formula ##STR1## wherein R is a hydrogen atom or hydroxyl group. These novel compounds according to this invention exhibit excellent antitumor activities and have a high solubility in water, and hence they are useful as an antitumor agent.

摘要翻译： 现在，合成7-O-（4-氨基-2,4,6-三脱氧-2-氟-α-L-吡喃甘露糖基） - 日诺霉素酮或阿曲达霉素，作为具有通式的道诺霉素酮或阿霉素酮衍生物，其中R是氢 原子或羟基。 根据本发明的这些新化合物表现出优异的抗肿瘤活性，并且在水中的溶解度高，因此它们可用作抗肿瘤剂。

公开(公告)号：US5750664A

公开(公告)日：1998-05-12

申请号：US461675

申请日：1995-06-05

申请人： William J. Christ ,  Daniel P. Rossignol ,  Seiichi Kobayashi ,  Tsutomu Kawata

发明人： William J. Christ ,  Daniel P. Rossignol ,  Seiichi Kobayashi ,  Tsutomu Kawata

IPC分类号： C07H15/12 ,  A61K31/70 ,  A61K31/7028 ,  A61P31/00 ,  A61P31/04 ,  C07H3/04 ,  C07H11/00 ,  C07H11/04 ,  C07H13/06 ,  C07H15/04 ,  C07H5/00

CPC分类号： C07H15/04 ,  A61K9/0073 ,  C07H11/00 ,  C07H15/12 ,  C07H3/04

摘要： Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.