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公开(公告)号：US20140228437A1
公开(公告)日：2014-08-14
申请号：US14258523
申请日：2014-04-22
申请人： Jean-Pierre SACHETTO , Roly BUFTON , Thomas BUSER
发明人： Jean-Pierre SACHETTO , Roly BUFTON , Thomas BUSER
IPC分类号： A61K31/202 , A61K9/48
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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公开(公告)号：US4665158A
公开(公告)日：1987-05-12
申请号：US739236
申请日：1985-05-30
CPC分类号： A23J3/32 , Y10S530/824 , Y10S530/825 , Y10S530/857 , Y10S530/859
摘要： Dehydrated protein materials are treated with gaseous HCl without temperature control, the reaction temperature being susceptible to reach, momentarily, 150.degree. C. Then the material thus treated is degassed and, after drying, a non hygroscopic powder usable in the food industry or in the pharmaceutical industry is obtained.
摘要翻译： 脱水的蛋白质材料在不进行温度控制的情况下用气态HCl处理，反应温度易于达到150℃。然后将如此处理的材料脱气，并且在干燥之后，可用于食品工业中的非吸湿粉末或 制药行业获得。
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3.发明授权Method for the simultaneous delignification of wood and other ligno-cellulosic materials and hydrolysis of the hemicellulose component thereof 失效木材和其他木质纤维素材料的同时脱木质素及其半纤维素成分的水解的方法
公开(公告)号：US4511433A
公开(公告)日：1985-04-16
申请号：US636061
申请日：1984-07-27
申请人： Herve Tournier , Allan A. Johansson , Jean-Pierre Sachetto , Jean-Michel Armanet , Jean-Pierre Michel , Alain Roman
发明人： Herve Tournier , Allan A. Johansson , Jean-Pierre Sachetto , Jean-Michel Armanet , Jean-Pierre Michel , Alain Roman
CPC分类号： D21C3/003 , D21C11/0042
摘要： A method for delignifying ligno-cellulosic materials and efficiently separate from each other the constituents thereof. Said materials are heated in an aqueous acid medium in the presence of phenol compounds. Then the reaction medium is drained and washed for isolating the purified solid cellulose pulp, the liquid phase separating into two layers: an aqueous layer rich with pentoses and an organic layer rich with phenols and lignin, the latter providing, by distillation and pyrolysis of the residue, a quantity of phenols at least equal to that of the phenols used in the delignification stage.
摘要翻译： 木质纤维素材料脱木质素的有效分离方法。 在苯酚化合物的存在下，所述材料在含水酸性介质中加热。 然后将反应介质排干并洗涤以分离纯化的固体纤维素纸浆，液相分离成两层：富含戊糖的水层和富含酚和木质素的有机层，后者通过蒸馏和热解 残余物，至少等于脱木质阶段中使用的酚的量的酚的量。
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公开(公告)号：US4199371A
公开(公告)日：1980-04-22
申请号：US892329
申请日：1978-03-31
CPC分类号： C13K1/02
摘要： Continuous hydrolysis to produce sugars is effected by cyclically immersing a solid, divided lignocellulosic material in a bath of concentrated hydrochloric acid and draining the material between successive immersions so as to dissolve the produced sugars, until the sugar concentration of the acid in the bath has attained a desired value.The solid material and the liquid acid are delivered to a tubular horizontal rotary reactor arranged to provide a bath of the acid, to produce a rotating movement for cyclical immersion of the solid material in the bath of acid and longitudinally displace the solid material undergoing hydrolysis together with the acid of the bath and to continuously discharge solid residue and acid containing dissolved sugars due to overflow by gravity at an outlet end of the reactor.
摘要翻译： 连续水解以产生糖通过将固体分离的木质纤维素材料循环浸入浓盐酸浴中并在连续浸渍之间排出材料以便溶解所产生的糖，直到浴中的酸的浓度达到 一个所需的值。 将固体材料和液体酸输送到管状水平旋转反应器，其布置成提供酸浴，以产生旋转运动，以将固体材料循环浸入酸浴中并纵向置换经历水解的固体材料 并且由于重力在反应器的出口端溢出而连续排出固体残余物和含有溶解的糖的酸。
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5.发明申请Pharmaceutical Compositions Containing Pufa And At Least One Of An Immunosuppressive Agent Or An Antineoplastic Agent 审中-公开含有Pufa和至少一种免疫抑制剂或抗肿瘤药物的药物组合物公开(公告)号：US20070219271A1
公开(公告)日：2007-09-20
申请号：US11597712
申请日：2005-06-15
IPC分类号： A61K31/20
CPC分类号： A61K45/06 , A61K9/4891 , A61K31/202 , A61K2300/00
摘要： Polyunsaturated fatty acid (“PUFA”) or a pharmacologically acceptable salt or derivative thereof (such as EPA and/or DHA) is used in combination with at least one of an immunosuppressive agent or an antineoplastic agent or a pharmacologically acceptable salt or derivative thereof in the treatment of conditions involving acutely or chronically inadequate immune response by topical application of said active agents to at least a portion of the intestinal mucosa. Specific conditions that may be treated include chronic inflammatory disease (e.g. Chrohn's disease and ulcerative colitis) and tumour disease (e.g. bowel cancer and prostate cancer). One advantage of preferred embodiments of the invention is that bioavailability of immunosuppressive or antineoplastic agents is increased.
摘要翻译： 多不饱和脂肪酸（“PUFA”）或其药理学上可接受的盐或其衍生物（例如EPA和/或DHA）与免疫抑制剂或抗肿瘤剂或其药理学上可接受的盐或衍生物中的至少一种联合使用 通过将所述活性剂局部施用于至少一部分肠粘膜来治疗涉及急性或慢性不足的免疫应答的病症。 可以治疗的具体情况包括慢性炎性疾病（例如，克罗恩氏病和溃疡性结肠炎）和肿瘤疾病（例如肠癌和前列腺癌）。 本发明的优选实施方案的一个优点是增加了免疫抑制剂或抗肿瘤剂的生物利用度。
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公开(公告)号：US5095054A
公开(公告)日：1992-03-10
申请号：US539846
申请日：1990-06-18
申请人： Gustav Lay , Johannes Rehm , Robert F. Stepto , Markus Thoma , Jean-Pierre Sachetto , David J. Lentz , Jakob Silbiger
发明人： Gustav Lay , Johannes Rehm , Robert F. Stepto , Markus Thoma , Jean-Pierre Sachetto , David J. Lentz , Jakob Silbiger
IPC分类号： A61K47/30 , A01N25/10 , A61K47/32 , A61K47/36 , C08J5/18 , C08L3/00 , C08L3/02 , C08L23/04 , C08L25/04 , C08L101/00
摘要： A thermoplastic polymer composition comprising:(a) a destructurized starch, and either(b) an effective amount of at least one compound selected from the following: (1) a polymer which contains at least two different types of functional groups, one of said types of these groups being hydroxyl groups; (2) at least one polymer which does not contain hydroxyl groups and is selected from the group consisting of polymers which contain at least two types of functional groups bound to the same molecule one type of these groups being carboxylate groups; (3) at least one polymer selected from the group consisting of polymers which contain tertiary amino groups and/or salts thereof and/or quaternary ammonium groups; (4) at least one polymer selected from the group of polysaccharides which have been chemically modified to contain added hydroxyalkyl groups and/or contain alkyl ether groups, and/or contain ester groups; (5) at least one compound selected from the group consisting of copolymers of vinyl pyrrolidone; (6) at least one compound selected from the group consisting of cationically modified polysaccharides; (7) at least one compound selected from the group consisting of anionically modified polysaccharides; (8) at least one polymer selected from the group of copolymers containing vinyl alcohol units together with aliphatic chain units as are obtained by copolymerization of vinyl esters, preferably vinyl acetate, with unsaturated monomers containing no functional group with subsequent hydrolysis of the vinyl ester group; (9) at least one compound selected from the group consisting of polysaccharide graft copolymers and graft copolymers of polysaccharide derivatives; (10) at least one compound selected from the group consisting of polyalkyleneimine polymers and polyalkyleneimine copolymers; (11) at least one compound selected from the group consisting of styrene sulfonic acid polymers, styrene sulfonic acid copolymers, and salts thereof; and (12) at least one compound selected from the group consisting of polymers and copolymers which contain carboxylic groups which partially or wholly are present in the form of their salts and wherein said polymers or copolymers do not contain further functional groups; or(c) At least one substantially water-insoluble thermoplastic polymer. combinations of (a), (b) and (c) are also disclosed.
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公开(公告)号：US4241089A
公开(公告)日：1980-12-23
申请号：US913834
申请日：1978-06-08
摘要： Feedstuff for livestock containing essentially carbohydrates (starches and cellulose based products) and glucosylurea of more than 90% purity. The glucosylurea is obtained by the condensation under acidic conditions of urea and glucose and the addition of 30-50% water which results, after final concentration and cooling, in the crystallization of pale yellow glucosylurea.
摘要翻译： 基本上含有超过90％纯度的碳水化合物（淀粉和纤维素基产品）和葡糖基脲的家畜饲料。 葡萄糖基脲是通过在尿素和葡萄糖的酸性条件下缩合得到的，加入30-50％的水，在最终浓缩和冷却后，在淡黄色葡萄糖基脲的结晶中。
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8.发明授权Photosensitive material containing di-iodopropyl cellulose, process for its manufacture and the use of this material 失效含有二异丙基纤维素的感光材料，其制造方法和本材料的使用
公开(公告)号：US4113483A
公开(公告)日：1978-09-12
申请号：US768494
申请日：1977-02-14
摘要： A photosensitive material is provided in which at least one surface portion of a substrate contains di-iodopropyl cellulose uniformly distributed therethrough. A photosensitive sheet material can be formed totally of di-iodopropyl cellulose or in part by di-iodopropyl cellulose, provided that the surface thereof contains di-iodopropyl cellulose. Upon exposure to electromagnetic radiation, including wave lengths not greater than 0.315 microns, radical iodine is liberated which forms molecular iodine spots to form an image corresponding to the intensity of the irradiation with the electromagnetic radiation. A provision is further made for bringing the surface of the material into contact with a substance which forms a colored compound upon reaction with the iodine.
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公开(公告)号：US20130123362A1
公开(公告)日：2013-05-16
申请号：US13734643
申请日：2013-01-04
申请人： Jean-Pierre Sachetto , Roly Button , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Button , Thomas Buser
IPC分类号： A61K9/48 , A61K31/202
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft to gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂的软明胶胶囊的一个优点是包含通过包括碱预处理胶原源的提取方法提取的明胶，是本发明不会随着时间的推移显着硬化，因此具有更长的搁架 生活。
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公开(公告)号：US07960370B2
公开(公告)日：2011-06-14
申请号：US10587201
申请日：2005-02-07
申请人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
IPC分类号： A61K31/33 , A61K31/194
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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