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公开(公告)号：US20130123362A1
公开(公告)日：2013-05-16
申请号：US13734643
申请日：2013-01-04
申请人： Jean-Pierre Sachetto , Roly Button , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Button , Thomas Buser
IPC分类号： A61K9/48 , A61K31/202
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft to gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂的软明胶胶囊的一个优点是包含通过包括碱预处理胶原源的提取方法提取的明胶，是本发明不会随着时间的推移显着硬化，因此具有更长的搁架 生活。
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公开(公告)号：US08383678B2
公开(公告)日：2013-02-26
申请号：US12984994
申请日：2011-01-05
申请人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
IPC分类号： A61K31/202 , A61K9/48
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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公开(公告)号：US20070269507A1
公开(公告)日：2007-11-22
申请号：US10587201
申请日：2005-02-07
申请人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
IPC分类号： A61K31/202 , A61K9/64 , A61P29/00 , A61P3/00
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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公开(公告)号：US07960370B2
公开(公告)日：2011-06-14
申请号：US10587201
申请日：2005-02-07
申请人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
IPC分类号： A61K31/33 , A61K31/194
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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公开(公告)号：US20110097394A1
公开(公告)日：2011-04-28
申请号：US12984994
申请日：2011-01-05
申请人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
发明人： Jean-Pierre Sachetto , Roly Bufton , Thomas Buser
IPC分类号： A61K31/202 , A61K9/48 , A61P29/00 , A61P3/06 , A61P11/06 , A61P35/00 , A61P1/04 , A61P17/06 , A61P19/02
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
摘要翻译： 包含游离酸形式的至少一种ω-3多不饱和脂肪酸或其药理学上可接受的衍生物的药物制剂包含在软明胶胶囊中，其特征在于所述胶囊包括通过提取方法提取的明胶，所述提取方法包括对胶原进行酸预处理 资源。 本发明相对于含有相同制剂但含有通过包括碱预处理胶原源的提取方法提取的明胶的软明胶胶囊的一个优点是本发明不会随着时间的推移显着硬化，因此具有更长的保质期 。
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公开(公告)号：US06217897B1
公开(公告)日：2001-04-17
申请号：US09147631
申请日：1999-04-05
申请人： Thomas Buser
发明人： Thomas Buser
IPC分类号： A61F1300
CPC分类号： A61K31/606 , A61K9/006 , A61K9/1274 , A61K47/14
摘要： A topical spreadable composition comprising 5-aminosalicylic acid (5-ASA) as active and monoolein is provided for treatment ulcers, inflammation and lesions of the oral cavity. The composition is spread over and adheres to the lesion, and is preferably prepared in a water free state. Examples of indications that can be treated are oral Crohn's Disease, apthous ulcers, orofacial granulomatosis, oral ulcers associated with Behet's disease and oral lichen planus.
摘要翻译： 提供包含作为活性的单 - 油酸的5-氨基水杨酸（5-ASA）的局部可涂敷组合物，用于治疗口腔溃疡，炎症和损伤。 将组合物铺展并附着于病变，优选以无水状态制备。 可以治疗的适应症的例子是口服克罗恩病，口疮性溃疡，口面肉芽肿病，与贝伐氏病和口腔扁平苔藓相关的口腔溃疡。
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7.发明授权Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids 失效使用ω-3多不饱和酸的口服剂型治疗炎症性肠病
公开(公告)号：US5792795A
公开(公告)日：1998-08-11
申请号：US687329
申请日：1996-08-07
申请人： Thomas Buser , Emilio P. Camporesi
发明人： Thomas Buser , Emilio P. Camporesi
CPC分类号： A61K31/202 , A61K9/4891 , Y10S514/963
摘要： Inflammatory bowel disease, especially Crohn's disease and ulcerative colitis, is treated by administration of an oral dosage form, containing as an active principle an omega-3 polyunsaturated acid in free acid form or as a pharmaceutically acceptable salt thereof, which releases the acid in the ileum. Preferably the oral dosage form is a gelatine capsule coated with a poly(ethylacrylate-methylmethacrylate).
摘要翻译： PCT No.PCT / EP96 / 02038 Sec。 371日期：1996年8月7日 102（e）日期1996年8月7日PCT提交1996年5月13日PCT公布。 WO96 / 36329 PCT出版物 日期1996年11月21日炎症性肠病，特别是克罗恩病和溃疡性结肠炎，通过给药口服剂型治疗，其以活性成分的形式含有游离酸形式的ω-3多不饱和酸或其药学上可接受的盐， 释放回肠酸。 优选地，口服剂型是用聚（丙烯酸乙酯 - 甲基丙烯酸甲酯）涂覆的明胶胶囊。
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8.发明授权Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids 失效使用ω-3多不饱和酸的口服剂型治疗炎症性肠病
公开(公告)号：US5948818A
公开(公告)日：1999-09-07
申请号：US69751
申请日：1998-04-30
申请人： Thomas Buser , Emilio P. Camporesi
发明人： Thomas Buser , Emilio P. Camporesi
CPC分类号： A61K31/202 , A61K9/4891 , Y10S514/963
摘要： Inflammatory bowel disease, especially Crohn's disease and ulcerative colitis, is treated by administration of an oral dosage form, containing as an active principle an omega-3 polyunsaturated acid in free acid form or as a pharmaceutically acceptable salt thereof, which releases the acid in the ileum. Preferably the oral dosage form is a gelatine capsule coated with a poly(ethylacrylate-methylmethacrylate).
摘要翻译： 炎症性肠病，特别是克罗恩病和溃疡性结肠炎，通过施用口服剂型治疗，其包含游离酸形式的ω-3多不饱和酸作为活性成分或其药学上可接受的盐，其释放酸中的酸 回肠。 优选地，口服剂型是用聚（丙烯酸乙酯 - 甲基丙烯酸甲酯）涂覆的明胶胶囊。
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