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1.发明授权Gene differentially expressed in breast and bladder cancer and encoded polypeptides 失效在乳腺癌和膀胱癌和编码多肽中差异表达的基因公开(公告)号：US07910551B2
公开(公告)日：2011-03-22
申请号：US12393860
申请日：2009-02-26
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorder in a subject. The invention further relates to uses of C35 polypeptides in immunogenic compositions or vaccines, to induce antibody or T cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The present invention further relates to use of C35 polypeptides in diagnosing a pathological condition or susceptibility to a pathological condition in a subject.
摘要翻译： 本发明涉及在人癌中差异表达的新型人基因。 更具体地，本发明涉及治疗或预防受试者中的病症的方法。 本发明还涉及C35多肽在免疫原性组合物或疫苗中的用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或T细胞介导的免疫。 本发明还涉及C35多肽在诊断受试者病理状况或病理状况易感性方面的应用。
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2.发明授权Gene differentially expressed in breast and bladder cancer, and encoded polypeptides 失效在乳腺癌和膀胱癌中差异表达的基因和编码的多肽公开(公告)号：US07268207B2
公开(公告)日：2007-09-11
申请号：US09824787
申请日：2001-04-04
IPC分类号： A61K38/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07H5/00 , C07H21/02 , C07H21/00 , C08B37/00 , C08B37/08
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptides, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
摘要翻译： 本发明涉及在人癌中差异表达的新型人基因。 更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。 本发明还涉及C35多肽，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。 本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。 本发明还涉及C35基因和多肽在免疫原性组合物或疫苗中的配制和用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或细胞介导的免疫。 本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。
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3.发明申请Gene Differentially Expressed in Breast and Bladder Cancer and Encoded Polypeptides 失效基因差异表达在乳腺癌和膀胱癌和编码多肽公开(公告)号：US20090312263A1
公开(公告)日：2009-12-17
申请号：US12393860
申请日：2009-02-26
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorder in a subject. The invention further relates to uses of C35 polypeptides in immunogenic compositions or vaccines, to induce antibody or T cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The present invention further relates to use of C35 polypeptides in diagnosing a pathological condition or susceptibility to a pathological condition in a subject.
摘要翻译： 本发明涉及在人癌中差异表达的新型人基因。 更具体地，本发明涉及治疗或预防受试者中的病症的方法。 本发明还涉及C35多肽在免疫原性组合物或疫苗中的用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或T细胞介导的免疫。 本发明还涉及C35多肽在诊断受试者病理状况或病理状况易感性方面的应用。
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