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公开(公告)号：US20220162594A1
公开(公告)日：2022-05-26
申请号：US17602254
申请日：2020-04-06
Applicant: xCella Biosciences, Inc.
Inventor： Vivian Hsieh , Bob Chen , Ryan Lewis Kelly
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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公开(公告)号：US20180163198A1
公开(公告)日：2018-06-14
申请号：US15376588
申请日：2016-12-12
Applicant: xCella Biosciences, Inc.
Inventor： Jennifer R. COCHRAN , Bob CHEN , Spencer Caleb ALFORD
CPC classification number: C12N15/1055 , B01L3/50857 , C12N15/1037 , C12N15/1086 , C12N15/81 , G01N33/53 , G01N33/5308 , G01N33/6845 , G01N2500/10 , G01N2500/20
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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公开(公告)号：US12024705B2
公开(公告)日：2024-07-02
申请号：US18047249
申请日：2022-10-17
Applicant: XCELLA Biosciences, Inc.
Inventor： Jennifer R. Cochran , Bob Chen , Spencer Caleb Alford
CPC classification number: C12N15/1037 , B01L3/50857 , G01N33/582 , G01N33/6845 , B01L2300/0893
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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公开(公告)号：US11156626B2
公开(公告)日：2021-10-26
申请号：US15853332
申请日：2017-12-22
Applicant: xCella Biosciences, Inc.
Inventor： Bob Chen
IPC: G01N35/10 , B01L9/00 , G01N15/14 , G01N33/543 , B01J19/00 , B01L3/00 , C12N15/10 , C12Q1/6851 , C40B60/02 , G01N21/75 , G01N35/00 , G01N21/64 , G01N21/03 , G01N15/10 , G01N21/77
Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.
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公开(公告)号：US11473081B2
公开(公告)日：2022-10-18
申请号：US16468260
申请日：2017-12-11
Applicant: XCELLA BIOSCIENCES, INC.
Inventor： Jennifer R. Cochran , Bob Chen , Spencer Caleb Alford
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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Patent Agency Ranking
公开(公告)号：US10227583B2
公开(公告)日：2019-03-12
申请号：US15489592
申请日：2017-04-17
Applicant: xCella Biosciences, Inc.
Inventor： Jennifer R. Cochran , Bob Chen , Spencer Caleb Alford
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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公开(公告)号：US20180188276A1
公开(公告)日：2018-07-05
申请号：US15853332
申请日：2017-12-22
Applicant: xCella Biosciences, Inc.
Inventor： Bob CHEN
CPC classification number: G01N35/10 , B01J19/0046 , B01J2219/00306 , B01J2219/00509 , B01J2219/00511 , B01J2219/00524 , B01J2219/00587 , B01J2219/00599 , B01J2219/00684 , B01J2219/00722 , B01J2219/00869 , B01J2219/0097 , B01L3/502715 , B01L3/50857 , B01L9/523 , B01L2200/0668 , B01L2200/142 , B01L2300/0816 , B01L2300/0829 , B01L2300/0893 , C12N15/1003 , C12Q1/6851 , C12Q2531/113 , C40B60/02 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N21/6428 , G01N21/75 , G01N33/54386 , G01N2015/1006 , G01N2021/0346 , G01N2021/6439 , G01N2021/755 , G01N2021/7769 , G01N2035/00158 , G01N2035/1039 , G01N2035/1053
Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.
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公开(公告)号：US20180164294A1
公开(公告)日：2018-06-14
申请号：US15489592
申请日：2017-04-17
Applicant: xCella Biosciences, Inc.
Inventor： Jennifer R. COCHRAN , Bob CHEN , Spencer Caleb ALFORD
CPC classification number: C12N15/1055 , B01L3/50857 , C12N15/1037 , C12N15/1086 , C12N15/81 , G01N33/53 , G01N33/5308 , G01N33/6845 , G01N2500/10 , G01N2500/20
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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公开(公告)号：US12228584B2
公开(公告)日：2025-02-18
申请号：US17506600
申请日：2021-10-20
Applicant: XCella Biosciences, Inc.
Inventor： Bob Chen
IPC: G01N35/10 , B01J19/00 , B01L3/00 , B01L9/00 , C12N15/10 , C12Q1/6851 , C40B60/02 , G01N15/14 , G01N15/1433 , G01N21/75 , G01N33/543 , G01N15/10 , G01N21/03 , G01N21/64 , G01N21/77 , G01N35/00
Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.
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公开(公告)号：US20240352444A1
公开(公告)日：2024-10-24
申请号：US18640571
申请日：2024-04-19
Applicant: XCELLA Biosciences, Inc.
Inventor： Jennifer R. Cochran , Bob Chen , Spencer Caleb Alford
CPC classification number: C12N15/1037 , B01L3/50857 , G01N33/582 , G01N33/6845 , B01L2300/0893
Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
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