公开(公告)号：US07348055B2

公开(公告)日：2008-03-25

申请号：US10028518

申请日：2001-12-21

Applicant: Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

Inventor： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC: B32B27/00

CPC classification number: B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

Abstract translation: 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US07056533B2

公开(公告)日：2006-06-06

申请号：US09901425

申请日：2001-07-09

Applicant: Stephen J. Chudzik ,  Terrence P. Everson ,  Richard A. Amos

Inventor： Stephen J. Chudzik ,  Terrence P. Everson ,  Richard A. Amos

IPC: A61K9/14 ,  A61K47/30

CPC classification number: A61L31/145 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  Y10S514/944 ,  C08L71/02

Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.

公开(公告)号：US06555587B1

公开(公告)日：2003-04-29

申请号：US10207944

申请日：2002-07-29

Applicant: Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

Inventor： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

IPC: A01N3500

CPC classification number: A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

公开(公告)号：US6121027A

公开(公告)日：2000-09-19

申请号：US916913

申请日：1997-08-15

Applicant: David L. Clapper ,  Melvin J. Swanson ,  Sheau-Ping Hu ,  Richard A. Amos ,  Terrence P. Everson

Inventor： David L. Clapper ,  Melvin J. Swanson ,  Sheau-Ping Hu ,  Richard A. Amos ,  Terrence P. Everson

IPC: A61L27/00 ,  A61L27/14 ,  A61L27/34 ,  A61L29/04 ,  A61L29/08 ,  A61L31/04 ,  A61L31/10 ,  A61L33/00 ,  C08J7/12 ,  C08L33/26 ,  C12N11/08 ,  C12Q1/00 ,  C12Q1/56 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/68 ,  G03F7/004 ,  A61K38/00 ,  C07K17/08 ,  G01N33/545

CPC classification number: G01N33/6845 ,  A61L27/14 ,  A61L27/34 ,  A61L29/04 ,  A61L29/085 ,  A61L31/04 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0047 ,  C08J7/12 ,  C12N11/08 ,  C12Q1/56 ,  C12Q1/6834 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/68 ,  G01N33/6854 ,  G01N2333/78 ,  G01N2333/8128 ,  G01N2333/815 ,  G01N2333/974 ,  Y10S530/815 ,  Y10S530/816

Abstract: A polybifunctional reagent is provided having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.

Abstract translation: 提供了具有聚合物主链，一个或多个侧基光反应性部分和两个或更多个侧链生物活性基团的多功能试剂。 试剂可以被活化以形成散装材料，或者可以与先前形成的生物材料的表面接触并活化以形成涂层。 悬浮生物活性基团通过促进特定分子或细胞附着到大块材料或涂层表面而起作用。 生物活性基团可以包括蛋白质，肽，碳水化合物，核酸和能够非共价结合分子或细胞的特定和互补部分的其它分子。

公开(公告)号：US5858653A

公开(公告)日：1999-01-12

申请号：US940213

申请日：1997-09-30

Applicant: Lise W. Duran ,  Melvin J. Swanson ,  Richard A. Amos ,  Sheau-Ping J. Hu ,  Patrick E. Guire

Inventor： Lise W. Duran ,  Melvin J. Swanson ,  Richard A. Amos ,  Sheau-Ping J. Hu ,  Patrick E. Guire

IPC: G01N33/53 ,  C07B61/00 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  C40B60/14 ,  G01N33/566 ,  C07C49/786 ,  C07C233/64 ,  C07D207/404

CPC classification number: B82Y30/00 ,  C07C235/84 ,  C07C323/42 ,  C07C45/63 ,  C12Q1/6834 ,  B01J2219/00317 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00716 ,  C07B2200/11 ,  C40B60/14 ,  Y10S436/905 ,  Y10T436/145555 ,  Y10T436/174614 ,  Y10T436/182 ,  Y10T436/200833

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of attracting the target molecule as well as groups capable of covalently binding to the target molecule, once attracted. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface.

Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 一旦被吸引，试剂组合物包括能够吸引靶分子的基团以及能够与靶分子共价结合的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。

公开(公告)号：US20100240789A1

公开(公告)日：2010-09-23

申请号：US12783907

申请日：2010-05-20

Applicant: Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

Inventor： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC: C08F2/46

CPC classification number: B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

Abstract translation: 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US06669994B2

公开(公告)日：2003-12-30

申请号：US09840406

申请日：2001-04-23

Applicant: Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC: C08F248

CPC classification number: C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

公开(公告)号：US06465525B1

公开(公告)日：2002-10-15

申请号：US09177318

申请日：1998-10-22

Applicant: Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

Inventor： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

IPC: A01N3500

CPC classification number: A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

Abstract translation: 用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂族酸（例如，脂肪酸），与间接基团组合，所述间隔基团以潜在的反应性基团与脂肪酸连接 这保留了每个组的所需功能。 一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和定向白蛋白的方式（例如，浓度和取向）在体内将脂肪酸呈现给生理环境。

公开(公告)号：US6077698A

公开(公告)日：2000-06-20

申请号：US2457

申请日：1998-01-02

Applicant: Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson

IPC: C12N11/06 ,  C07B61/00 ,  C07C45/63 ,  C07C225/16 ,  C07C309/14 ,  C07D295/10 ,  C07D295/112 ,  C07D487/18 ,  C07K17/06 ,  C08J3/24 ,  C09K3/00 ,  G01N33/543 ,  C12N11/00 ,  C07C49/76 ,  G01N33/549

CPC classification number: C07D295/112 ,  C07C225/16 ,  C07C309/14 ,  C07C45/63 ,  C07K17/06 ,  G01N33/54353 ,  Y10S530/81 ,  Y10S530/816

Abstract: A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged to improve water solubility, and two or more photoreactive groups (preferably comprising an aryl ketone such as benzophenone) that allow use of the agent in aqueous systems. Charged groups include salts of organic acids such as sulfonate, phosphonate and carboxylate groups, onium groups such as quaternary ammonium, sulfonium and phosphonium groups, and protonated amines. A surface can be coated with a substance such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the substance, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the substance to the surface.

Abstract translation: 化学连接剂由具有至少一个被加入以改善水溶性的基团的二官能或更高官能的可光活化化合物形成，以及允许使用该试剂的两种或多种光反应性基团（优选包含芳基酮如二苯甲酮） 在水系统中。 带电基团包括有机酸的盐，例如磺酸盐，膦酸盐和羧酸盐基团，鎓基团如季铵盐，锍盐和鏻基团以及质子化胺。 通过形成连接剂和物质的水溶液，将表面与合成聚合物，碳水化合物，蛋白质，脂质，核酸，药物，维生素，辅因子或染料等物质包衣，将溶液与 表面并活化连接剂的光反应性基团以使物质与表面交联。

公开(公告)号：US07794751B2

公开(公告)日：2010-09-14

申请号：US11387508

申请日：2006-03-23

Applicant: Stephen J. Chudzik ,  Terrence P. Everson ,  Richard A. Amos

Inventor： Stephen J. Chudzik ,  Terrence P. Everson ,  Richard A. Amos

IPC: A61K9/14

CPC classification number: A61L31/145 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  Y10S514/944 ,  C08L71/02

Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.

Abstract translation: 一种涂料组合物，以其未交联和交联的形式，用于从体内定位的医疗装置的表面递送药物。 一旦交联，涂层组合物提供了一种凝胶基质，其适于以允许药物在体内以延长，受控，可预测和有效的方式从基质释放的形式容纳药物。 组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体如（甲基）丙烯酸，光衍生化单体和亲水性单体如丙烯酰胺。