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公开(公告)号：US20120232005A1
公开(公告)日：2012-09-13
申请号：US13367237
申请日：2012-02-06
CPC分类号： A61K38/1709 , A61K38/17 , A61K38/18 , A61K45/00 , A61K47/50 , C07K1/04 , C07K1/042 , C07K14/775 , Y10T428/2982
摘要： The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
摘要翻译： 本公开涉及脂蛋白复合物和脂蛋白种群及其在治疗和/或预防血脂异常疾病，病症和/或病症中的用途。 本公开还涉及载脂蛋白的重组表达，载脂蛋白的纯化，以及使用基于热循环的方法产生脂蛋白复合物。
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2.发明申请KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 有权酮类化合物和组合物用于胆固醇管理及相关用途公开(公告)号：US20120129930A1
公开(公告)日：2012-05-24
申请号：US13297058
申请日：2011-11-15
IPC分类号： A61K31/215 , A61P25/28 , A61P35/00 , A61P9/00 , A61P3/06 , A61P3/00 , A61P1/00 , A61P3/04 , A61P1/18 , A61P25/16 , A61P13/12 , A61P31/00 , A61P7/02 , A61P19/02 , A61P37/00 , A61P17/00 , A61P19/06 , A61P9/12 , A61P29/00 , A61K31/20 , A61P19/04 , A61P43/00 , A61P1/16 , A61K31/194
CPC分类号： C07C59/353 , C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/784 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/82 , C07C59/84 , C07C59/90 , C07C69/716 , C07C69/738 , C07C235/74 , C07C261/04 , C07C309/07 , C07C309/24 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳ence 。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US20100015220A1
公开(公告)日：2010-01-21
申请号：US12469653
申请日：2009-05-20
申请人： John R. WETTERAU , Lingyu Zhu , Robert A. Scott , Constance H. Keyserling , Jean-Louis H. Dasseux , Daniela Carmen Oniciu , Pierre Autant , Roger Kravtzoff , Catherine Castan , Hervé Guillard
发明人： John R. WETTERAU , Lingyu Zhu , Robert A. Scott , Constance H. Keyserling , Jean-Louis H. Dasseux , Daniela Carmen Oniciu , Pierre Autant , Roger Kravtzoff , Catherine Castan , Hervé Guillard
CPC分类号： A61K31/455 , A61K31/616 , A61K2300/00
摘要： Provided are pharmaceutical compositions and methods for preventing or reducing niacin-induced flushing comprising an aspirin component and a niacin component having different release profiles. Also provided are methods and compositions for preventing or reducing niacin-induced flushing comprising niacin, aspirin and a lipid-lowering drug other than niacin.
摘要翻译： 提供了用于预防或减少烟酸诱发的潮红的药物组合物和方法，其包含具有不同释放特征的阿司匹林组分和烟酸组分。 还提供了用于预防或减少烟酸诱发的潮红的方法和组合物，其包含烟酸，阿司匹林和除了烟酸以外的降脂药物。
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4.发明申请Use of PPAR Delta Ligands for the Treatment or Prevention of Inflammation or Energy Metabolism/Production Related Diseases 审中-公开使用PPAR Delta配体治疗或预防炎症或能量代谢/生产相关疾病公开(公告)号：US20110092517A1
公开(公告)日：2011-04-21
申请号：US12856532
申请日：2010-08-13
申请人： Ronald Barbaras , Daniela Carmen Oniciu , Jean-Louis H. Dasseux , Robert A. Scott , John R. Wetterau
发明人： Ronald Barbaras , Daniela Carmen Oniciu , Jean-Louis H. Dasseux , Robert A. Scott , John R. Wetterau
IPC分类号： A61K31/496 , A61P11/00 , A61P11/06 , A61P29/00 , A61P9/10 , A61P19/02 , A61P3/10 , A61P3/04 , A61P5/50 , A61P9/12 , A61P3/06 , A61P21/00 , A61P25/08 , A61P17/14 , A61K31/426 , A61K31/423 , A61P17/02 , A61K31/421 , A61K31/4164 , A61K31/4709 , A61K31/506 , A61K31/4439 , A61K31/415 , A61K31/381
CPC分类号： A61K31/381 , A61K31/382 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426
摘要： Provided herein are methods for treatment, prevention, or amelioration of one or more symptoms of a disease or condition related to disorders of insulin and/or glucose metabolism, inflammatory conditions, mitochondrial disease, muscle disorders, or pulmonary disorders, involving administering a PPARδ agonist or a pharmaceutical composition comprising a PPARδ agonist. In one embodiment, the disease or condition is selected from myopathy, inflammatory vascular diseases, Parkinson's and Alzheimer's diseases, systemic inflammatory disorders, renal ischemia, inflammatory rheumatic disorders, and inflammatory diseases of the lung. In another embodiment, methods for increasing oxidative muscle fibers, reducing mitochondria disease, decreasing insulin resistance, decreasing plasma glucose, or decreasing weight, involving administering a PPARδ agonist or a pharmaceutical composition comprising a PPARδ agonist, are provided.
摘要翻译： 本文提供了治疗，预防或改善与胰岛素和/或葡萄糖代谢紊乱，炎性病症，线粒体疾病，肌肉病症或肺部疾病相关的疾病或病症的一种或多种症状的方法，包括施用PPARδ激动剂 或包含PPARδ激动剂的药物组合物。 在一个实施方案中，疾病或病症选自肌病，炎性血管疾病，帕金森病和阿尔茨海默病，全身性炎性疾病，肾缺血，炎性风湿病和肺炎性疾病。 在另一个实施方案中，提供了包括施用PPARδ激动剂或包含PPARδ激动剂的药物组合物的用于增加氧化性肌纤维，减少线粒体疾病，降低胰岛素抵抗，降低血浆葡萄糖或降低体重的方法。
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5.发明授权Ketone compounds and compositions for cholesterol management and related uses 有权酮类化合物和胆固醇管理及相关用途的组合物公开(公告)号：US08084498B2
公开(公告)日：2011-12-27
申请号：US12492597
申请日：2009-06-26
IPC分类号： A61K31/19
CPC分类号： C07C59/353 , C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/784 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/82 , C07C59/84 , C07C59/90 , C07C69/716 , C07C69/738 , C07C235/74 , C07C261/04 , C07C309/07 , C07C309/24 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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6.发明申请公开(公告)号：US20080249166A1
公开(公告)日：2008-10-09
申请号：US12135504
申请日：2008-06-09
IPC分类号： A61K31/216 , A61K31/192 , A61K31/22 , C07C69/74 , C07C61/06 , A61P9/00 , C07C61/04 , C07C69/743 , A61K31/191
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新的环烷基 - 羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病 视网膜病变，葡萄糖代谢紊乱，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质消除，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除 胆汁，肾脏疾病，败血症，X综合征，血栓形成障碍。 本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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7.发明授权Cycloalkyl-hydroxyl compounds and compositions for cholesterol management 有权用于胆固醇管理的环烷基 - 羟基化合物和组合物公开(公告)号：US08067466B2
公开(公告)日：2011-11-29
申请号：US12135504
申请日：2008-06-09
IPC分类号： A61K31/194 , A61K31/225 , C07C63/331 , C07C69/74
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新的环烷基 - 羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病 视网膜病变，葡萄糖代谢紊乱，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质消除，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除 胆汁，肾脏疾病，败血症，X综合征，血栓形成障碍。 本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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8.发明授权公开(公告)号：US08349833B2
公开(公告)日：2013-01-08
申请号：US13276238
申请日：2011-10-18
申请人： Daniela Carmen Oniciu , Jean-Louis Henri Dasseux , Ronald Barbaras , Valery Kochubey , Dmitry Kovalsky , Oleg Gennadievich Rodin , Otto Geoffroy , Anna Rzepiela
发明人： Daniela Carmen Oniciu , Jean-Louis Henri Dasseux , Ronald Barbaras , Valery Kochubey , Dmitry Kovalsky , Oleg Gennadievich Rodin , Otto Geoffroy , Anna Rzepiela
IPC分类号： A61K31/5377 , A61K31/505 , C07D413/14 , C07D403/14 , C07D403/02 , C07D239/24
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/155 , A61K31/194 , A61K31/198 , A61K31/20 , A61K31/201 , A61K31/353 , A61K31/4365 , A61K31/506 , A61K31/575 , A61K31/7032 , C07D319/18 , C07D401/04 , C07D401/14 , C07D471/04 , C07D493/04 , C07D495/04 , C07D513/04 , G01N33/92 , G01N2800/52
摘要： The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
摘要翻译： 本发明涉及药物活性杂环化合物及其药学上可接受的盐及其水合物及其组合物。 本发明还涉及治疗或预防疾病或病症的方法，其包括给予治疗或预防有效量的本文所述的化合物。
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9.发明申请公开(公告)号：US20120129856A1
公开(公告)日：2012-05-24
申请号：US13276238
申请日：2011-10-18
申请人： Daniela Carmen Oniciu , Jean-Louis Henri Dasseux , Ronald Barbaras , Valery Kochubey , Dmitry Kovalsky , Oleg Gennadievich Rodin , Otto Geoffroy , Anna Rzepiela
发明人： Daniela Carmen Oniciu , Jean-Louis Henri Dasseux , Ronald Barbaras , Valery Kochubey , Dmitry Kovalsky , Oleg Gennadievich Rodin , Otto Geoffroy , Anna Rzepiela
IPC分类号： A61K31/5377 , C07D491/048 , C07D471/04 , A61K31/4365 , A61K31/4355 , A61K31/437 , C07D413/14 , C07D401/14 , A61K31/513 , C07D319/18 , A61K31/357 , C12Q1/60 , A61P3/00 , A61P9/00 , A61P29/00 , A61P9/10 , A61P35/00 , A61P7/02 , A61P25/28 , A61P25/16 , A61P1/18 , C07D495/04
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/155 , A61K31/194 , A61K31/198 , A61K31/20 , A61K31/201 , A61K31/353 , A61K31/4365 , A61K31/506 , A61K31/575 , A61K31/7032 , C07D319/18 , C07D401/04 , C07D401/14 , C07D471/04 , C07D493/04 , C07D495/04 , C07D513/04 , G01N33/92 , G01N2800/52
摘要： The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
摘要翻译： 本发明涉及药物活性杂环化合物及其药学上可接受的盐及其水合物及其组合物。 本发明还涉及治疗或预防疾病或病症的方法，其包括给予治疗或预防有效量的本文所述的化合物。
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10.发明申请KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 有权酮类化合物和组合物用于胆固醇管理及相关用途公开(公告)号：US20100137444A1
公开(公告)日：2010-06-03
申请号：US12492597
申请日：2009-06-26
IPC分类号： A61K31/121 , A61K31/194 , C07C59/347 , C07C49/17 , C07C59/185 , A61P3/06
CPC分类号： C07C59/353 , C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/784 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/82 , C07C59/84 , C07C59/90 , C07C69/716 , C07C69/738 , C07C235/74 , C07C261/04 , C07C309/07 , C07C309/24 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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