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33 条记录 (耗时 0.028 秒)

    Method for manufacturing prostaglandin analogue
    4.
    发明申请
    Method for manufacturing prostaglandin analogue 有权
    制备前列腺素类似物的方法

    公开(公告)号：US20060036108A1

    公开(公告)日：2006-02-16

    申请号：US11193373

    申请日：2005-08-01

    申请人： Ryu Hirata ,  Tatsuya Matsukawa

    发明人： Ryu Hirata ,  Tatsuya Matsukawa

    IPC分类号： C07C61/06

    CPC分类号： C07C51/373 ,  C07C405/00 ,  C07C59/353

    摘要： The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containing compound with a co-oxidizer under the presence of a tetramethylpyperidine-1-oxyl derivative to form the desired prostaglandin analogue. The method of the invention can be carried out easily under relatively mild conditions.

    摘要翻译： 本发明提供了一种制备在5元环和/或ω链上具有一个或多个酮基的前列腺素类似物的新方法，其包括在存在下用共氧化剂处理相应的含羟基化合物的步骤 的四甲基吡啶-1-氧代衍生物形成所需的前列腺素类似物。 本发明的方法可以在相对温和的条件下容易地进行。

    Process for preparing beta-keto-acids
    6.
    发明授权
    Process for preparing beta-keto-acids 失效
    制备β-葡萄糖酸的方法

    公开(公告)号：US3557196A

    公开(公告)日：1971-01-19

    申请号：US3557196D

    申请日：1967-07-31

    申请人： MONTEDISON SPA

    发明人： BOTTACCIO GIORGIO ,  CHIUSOLI GIAN PAOLO

    IPC分类号： C07C51/15 ,  C07C61/36

    CPC分类号： C07C51/15 ,  C07C59/84 ,  C07C59/347 ,  C07C59/195 ,  C07C59/205 ,  C07C59/353

    摘要： DISCLOSED IS A PROCESS FOR PREPARING BETA-KETO-ACIDS HAVING THE FORMULA R-CO-CHR''-COOH FROM KETONES R-CO-CH2-R'' WHEREIN R AND R'' ARE HYDROCARBYLS CONTAINING 1 TO 10 C; R'' MAY BE H; R AND R'' TAKEN TOGETHER GIVE A CYCLOALKYLENE. THE PROCESS IS CHARACTERIZED IN THAT THE KETONE IS REACTED WITH CARBON DIOXIDE, IN THE PRESENCE OF ALKALINE SALTS OF PHENOLS IN AN INERT POLAR MEDIUM. THE ALKALINE PHENOL SALTS PREFERRED ARE THE LI, NA, K SALTS OF PHENOL, HYDROQUINONE AND THEIR METHYL HOMOLOGS. THE INERT POLAR MEDIUM IS PREFERABLY SELECTED FROM TRIALKYLPHOSPHINOXIDES, TRIALKYL-PHOSPHATES, HEXALKYL-PHOSPHOTRIAMIDES, DIALKYL-SULPHOXIDES, DIALKYLFORMAMIDES, DIALKYL-ACETAMIDES, TETRALKYLUREAS, PYRIDINE, DIALKYLETHERS OF MONO-, DI- AND TRI-ETHYLENEGLYCOL, WHEREIN ALKYL IS METHYL AND/OR ETHYL.

    Method for manufacturing prostaglandin analogue
    9.
    发明授权
    Method for manufacturing prostaglandin analogue 有权
    前列腺素类似物的制备方法

    公开(公告)号：US07321057B2

    公开(公告)日：2008-01-22

    申请号：US11193373

    申请日：2005-08-01

    申请人： Ryu Hirata ,  Tatsuya Matsukawa

    发明人： Ryu Hirata ,  Tatsuya Matsukawa

    IPC分类号： C07C61/06 ,  C07C49/00 ,  C07C35/06

    CPC分类号： C07C51/373 ,  C07C405/00 ,  C07C59/353

    摘要： The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containing compound with a co-oxidizer under the presence of a tetramethylpyperidine-1-oxyl derivative to form the desired prostaglandin analogue. The method of the invention can be carried out easily under relatively mild conditions.

    摘要翻译： 本发明提供了一种制备在5元环和/或ω链上具有一个或多个酮基的前列腺素类似物的新方法，其包括在存在下用共氧化剂处理相应的含羟基化合物的步骤 的四氢吡啶-1-氧基衍生物以形成所需的前列腺素类似物。 本发明的方法可以在相对温和的条件下容易地进行。