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1.发明授权公开(公告)号：US08999989B2
公开(公告)日：2015-04-07
申请号：US12991035
申请日：2009-05-29
Applicant: Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
Inventor： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
IPC: A61K31/496 , C07D241/04 , C07D213/74 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
CPC classification number: A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/497 , A61K31/505 , A61K31/506 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D213/72 , C07D213/74 , C07D213/75 , C07D233/64 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/10 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供可用作VAP-1抑制剂的新型苯衍生物或噻吩衍生物，或用于预防或治疗VAP-1相关疾病等的药物，即由式（I）表示的化合物： 其中每个符号如本说明书中所定义，或其药学上可接受的盐。
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公开(公告)号：US08389748B2
公开(公告)日：2013-03-05
申请号：US12762917
申请日：2010-04-19
Applicant: Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
Inventor： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC: C07D307/85 , C07C57/26 , C07C69/608
CPC classification number: C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
Abstract translation: 公开了一种制备式（A）的前列腺素衍生物的方法：其包括在碱性氢氧化物作为唯一碱的存在下，在反应溶剂中使由式（1）表示的醛与2-氧代烷基膦酸酯反应。 通过在反应体系中使用碱金属氢氧化物作为底物进行反应，可以通过简单的方法和高收率获得所需的前列腺素衍生物。
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公开(公告)号：US20100274032A1
公开(公告)日：2010-10-28
申请号：US12762906
申请日：2010-04-19
Applicant: Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
Inventor： Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC: C07D309/12
CPC classification number: C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
Abstract translation: 公开了一种制备式（A）的前列腺素衍生物的方法：其包括在碱性氢氧化物作为唯一碱的存在下，在反应溶剂中使由式（1）表示的醛与2-氧代烷基膦酸酯反应。 通过在反应体系中使用碱金属氢氧化物作为底物进行反应，可以通过简单的方法和高收率获得所需的前列腺素衍生物。
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公开(公告)号：US09212158B2
公开(公告)日：2015-12-15
申请号：US13537980
申请日：2012-06-29
Applicant: Tatsuya Matsukawa , Noriyuki Yamamoto
Inventor： Tatsuya Matsukawa , Noriyuki Yamamoto
IPC: C07D317/30 , C07C405/00 , C07F7/18
CPC classification number: C07D317/30 , C07C405/00 , C07C2601/08 , C07F7/1804
Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 and R4 are hydrogen atom, halogen atom, lower alkyl or lower alkoxy; when R3 and R4 are lower alkoxy, R3 and R4 may be linked together to form a ring structure; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1; with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
Abstract translation: 提供了制备由式（I）表示的脂肪酸衍生物的方法：其中Z1是R3和R4是氢原子，卤素原子，低级烷基或低级烷氧基; 当R3和R4是低级烷氧基时，R3和R4可以连接在一起形成环结构; 其包括使式（II）化合物：其中Z2与Z1相同的步骤; 与共氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应。
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公开(公告)号：US20130005995A1
公开(公告)日：2013-01-03
申请号：US13538189
申请日：2012-06-29
Applicant: Tatsuya MATSUKAWA , Noriyuki YAMAMOTO , Ryuji UENO , Hiroyuki KOTAJIMA , Shunsuke FUKUYA , Michiharu HANDA , Katsuya SAKATA
Inventor： Tatsuya MATSUKAWA , Noriyuki YAMAMOTO , Ryuji UENO , Hiroyuki KOTAJIMA , Shunsuke FUKUYA , Michiharu HANDA , Katsuya SAKATA
IPC: C07D309/12
CPC classification number: C07D307/30 , Y02P20/55
Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
Abstract translation: 提供一种制备式（I）表示的脂肪酸衍生物的方法：其中Z 1是其中R 3是羟基的保护基; 其包括使式（II）化合物：其中Z2与Z 1相同，除了当Z 1为Z 2时，其为与氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应的步骤。
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公开(公告)号：US20100204491A1
公开(公告)日：2010-08-12
申请号：US12762890
申请日：2010-04-19
Applicant: Ryu HIRATA , Tatsuya Matsukawa , Kazuchiro Masuzaki , Ryuji Ueno
Inventor： Ryu HIRATA , Tatsuya Matsukawa , Kazuchiro Masuzaki , Ryuji Ueno
IPC: C07D309/06
CPC classification number: C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
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公开(公告)号：US4937507A
公开(公告)日：1990-06-26
申请号：US367291
申请日：1989-06-16
Applicant: Hisayuki Masui , Toshiaki Matsuura , Ryuichi Simada , Tatsuya Matsukawa
Inventor： Hisayuki Masui , Toshiaki Matsuura , Ryuichi Simada , Tatsuya Matsukawa
Abstract: A generator driving apparatus is provided with a thyristor driving device for driving a motor-generator, and the thyristor driving device always controls the driving of the motor-generator regardless of the number of rotations thereof. Also, when the motor-generator is coming to a stop, energy conserved in the motor-generator is regenerated to an electric power system through the thyristor driving device.
Abstract translation: 发电机驱动装置设置有用于驱动电动发电机的晶闸管驱动装置，并且晶闸管驱动装置始终控制电动发电机的驱动，而不管其转数如何。 此外，当电动发电机停机时，通过晶闸管驱动装置将电动发电机中的节能再生成电力系统。
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公开(公告)号：US08507690B2
公开(公告)日：2013-08-13
申请号：US12864773
申请日：2009-01-30
Applicant: Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
Inventor： Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
IPC: C07D277/38 , A61K31/427 , A61K31/426
CPC classification number: C07D277/46 , C07D417/06
Abstract: The invention provides a thiazole derivative useful as a VAP-1 inhibitor, as well as a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like, a method of inhibiting VAP-1 in a subject, and a method for the prophylaxis or treatment of VAP-1 associated disease in a subject. The thiazole derivative is a compound represented by the formula (I): R1—NH—X—Y—Z wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供了可用作VAP-1抑制剂的噻唑衍生物，以及用于预防或治疗VAP-1相关疾病等的药剂，抑制受试者中VAP-1的方法， 预防或治疗受试者中VAP-1相关疾病。 噻唑衍生物是由式（I）表示的化合物：其中各符号如说明书中所定义，或其药学上可接受的盐，其中R1-NH-X-Y-Z。
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公开(公告)号：US08236969B2
公开(公告)日：2012-08-07
申请号：US12762890
申请日：2010-04-19
Applicant: Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
Inventor： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC: C07D309/12 , C07F7/18
CPC classification number: C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
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10.发明申请
公开(公告)号：US20110059957A1
公开(公告)日：2011-03-10
申请号：US12991035
申请日：2009-05-29
Applicant: Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
Inventor： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
IPC: A61K31/167 , C07C243/18 , C07D213/74 , C07D233/64 , C07D413/04 , C07D241/20 , C07D241/24 , C07D265/36 , A61K31/44 , A61K31/4174 , A61K31/5377 , A61K31/4965 , A61K31/454 , A61K31/222 , A61K31/538 , A61P27/02 , A61P9/10 , A61P27/06 , A61P29/00 , A61P3/10 , A61P19/02 , A61P17/00 , A61P1/00 , A61P11/06 , A61P25/28
CPC classification number: A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/497 , A61K31/505 , A61K31/506 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D213/72 , C07D213/74 , C07D213/75 , C07D233/64 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/10 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供可用作VAP-1抑制剂的新型苯衍生物或噻吩衍生物，或用于预防或治疗VAP-1相关疾病等的药物，即由式（I）表示的化合物： 其中每个符号如本说明书中所定义，或其药学上可接受的盐。
