公开(公告)号：US20140121328A1

公开(公告)日：2014-05-01

申请号：US14147983

申请日：2014-01-06

Applicant: Elizabeth L Hedberg-Dirk ,  Shawn Dirk ,  Kirsten Cicotte

Inventor： Elizabeth L Hedberg-Dirk ,  Shawn Dirk ,  Kirsten Cicotte

IPC: C08F222/10

CPC classification number: C08G63/52 ,  C08F222/10

Abstract: A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

Abstract translation: 描述适合用作生物相容性构建体的多种聚合物和共聚物，以及作为非限制性具体实例的可降解组织支架的形成以及用于合成这些聚合物和共聚物的方法。 聚合物和共聚物的降解速率明显快于适用于相同用途的前述聚合物的降解速率。 还描述了具有能够通过选择所得共聚物中单体的特定化学计量来微调降解速率的合成途径的共聚物。 本公开还提供了一种用于马来酰氯的新型合成路线，其产生适用于本文所述共聚物合成方法的单体。

公开(公告)号：US08679381B1

公开(公告)日：2014-03-25

申请号：US13227413

申请日：2011-09-07

Applicant: Zayd Chad Leseman ,  Mark Andrew Atwater ,  Jonathan Phillips

Inventor： Zayd Chad Leseman ,  Mark Andrew Atwater ,  Jonathan Phillips

IPC: C01B31/00

CPC classification number: D01F9/133 ,  B82Y30/00 ,  C01B32/00 ,  D01F9/127

Abstract: Exemplary embodiments provide methods and apparatus of forming fibrous carbon foams (FCFs). In one embodiment, FCFs can be formed by flowing a fuel rich gas mixture over a catalytic material and components to be encapsulated in a mold to form composite carbon fibers, each composite carbon fiber having a carbon phase grown to encapsulate the component in situ. The composite carbon fibers can be intertwined with one another to form FCFs having a geometry according to the mold.

Abstract translation: 示例性实施方案提供了形成纤维状碳泡沫（FCF）的方法和装置。 在一个实施方案中，FCF可以通过使富含燃料的气体混合物流过催化材料并将要包封在模具中的组分形成复合碳纤维而形成，每个复合碳纤维具有生长以原位包封组分的碳相。 复合碳纤维可以彼此缠结以形成具有根据模具的几何形状的FCF。

公开(公告)号：US20140079774A1

公开(公告)日：2014-03-20

申请号：US14113371

申请日：2012-04-27

Applicant: C. Jeffrey Brinker ,  Eric C. Carnes ,  Carleen Erin Ashley

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carleen Erin Ashley

IPC: A61K9/127 ,  A61K45/06 ,  A61K31/704 ,  A61K31/711

CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 促进癌细胞死亡的至少一种试剂（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：US20140064312A1

公开(公告)日：2014-03-06

申请号：US14032904

申请日：2013-09-20

Applicant: STC.UNM

Inventor： Seung Chang Lee ,  Steven R.J. Brueck

IPC: H01L21/02 ,  H01S5/32 ,  H01L29/15

CPC classification number: H01L21/02603 ,  B82Y10/00 ,  B82Y40/00 ,  B82Y99/00 ,  H01L21/0237 ,  H01L21/02439 ,  H01L21/02507 ,  H01L21/02521 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/127 ,  H01L29/158 ,  H01L29/7783 ,  H01L29/7853 ,  H01L33/06 ,  H01L33/18 ,  H01S5/32 ,  Y10S977/951 ,  Y10S977/962

Abstract: Exemplary embodiments provide semiconductor nanowires and nanowire devices/applications and methods for their formation. In embodiments, in-plane nanowires can be epitaxially grown on a patterned substrate, which are more favorable than vertical ones for device processing and three-dimensional (3D) integrated circuits. In embodiments, the in-plane nanowire can be formed by selective epitaxy utilizing lateral overgrowth and faceting of an epilayer initially grown in a one-dimensional (1D) nanoscale opening. In embodiments, optical, electrical, and thermal connections can be established and controlled between the nanowire, the substrate, and additional electrical or optical components for better device and system performance.

Abstract translation: 示例性实施例提供用于其形成的半导体纳米线和纳米线器件/应用和方法。 在实施例中，平面内纳米线可以在图案化衬底上外延生长，其比用于器件处理和三维（3D）集成电路的垂直纳米线更有利。 在实施方案中，可以通过使用最初在一维（1D）纳米尺度开口中生长的外延层的横向过生长和刻面的选择性外延来形成平面内纳米线。 在实施例中，可以在纳米线，衬底和附加电气或光学部件之间建立和控制光学，电气和热连接，以获得更好的器件和系统性能。

公开(公告)号：US08658519B1

公开(公告)日：2014-02-25

申请号：US13677203

申请日：2012-11-14

Applicant: STC.UNM

Inventor： Stephen D. Hersee

IPC: H01L21/20

CPC classification number: H01L29/0676 ,  H01L21/02439 ,  H01L21/02488 ,  H01L21/0254 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02639 ,  H01L29/2003 ,  H01L29/7787

Abstract: Various embodiments provide non-planar nanowires, nanowire arrays, and nanowire networks as well as methods of their formation and applications. The non-planar nanowires and their arrays can be formed in a controlled manner on surfaces having a non-planar orientation. In embodiments, two or more adjacent nanowires from different surfaces can grow to merge together forming one or more nanowire branches and thus forming a nanowire network. In embodiments, the non-planar nanowires and nanowire networks can be used for cantilever oscillation, switching and transistor actions.

Abstract translation: 各种实施例提供非平面纳米线，纳米线阵列和纳米线网络以及它们的形成和应用的方法。 非平面纳米线及其阵列可以以受控的方式形成在具有非平面取向的表面上。 在实施例中，来自不同表面的两个或更多个相邻的纳米线可以生长以合并在一起形成一个或多个纳米线分支，从而形成纳米线网络。 在实施例中，非平面纳米线和纳米线网络可用于悬臂振荡，开关和晶体管动作。

公开(公告)号：US08642139B2

公开(公告)日：2014-02-04

申请号：US12480812

申请日：2009-06-09

Applicant: Angela Michelle Knapp ,  Monique N. Richard ,  Claudia Luhrs ,  Timothy Blada ,  Jonathan Phillips

Inventor： Angela Michelle Knapp ,  Monique N. Richard ,  Claudia Luhrs ,  Timothy Blada ,  Jonathan Phillips

IPC: B05D1/08 ,  H05H1/24 ,  B32B27/32

CPC classification number: C23C16/513 ,  C23C16/26 ,  C23C16/4417

Abstract: Disclosed is a process for making a composite material that contains structured particles. The process includes providing a first precursor in the form of a dry precursor powder, a precursor liquid, a precursor vapor of a liquid and/or a precursor gas. The process also includes providing a plasma that has a high field zone and passing the first precursor through the high field zone of the plasma. As the first precursor passes through the high field zone of the plasma, at least part of the first precursor is decomposed. An aerosol having a second precursor is provided downstream of the high field zone of the plasma and the decomposed first material is allowed to condense onto the second precursor to from structured particles.

Abstract translation: 公开了一种制备含有结构化颗粒的复合材料的方法。 该方法包括提供干燥前体粉末，前体液体，液体前体蒸气和/或前体气体形式的第一前体。 该方法还包括提供具有高场区并使第一前体通过等离子体的高场区的等离子体。 当第一个前体经过等离子体的高场区时，第一个前体的至少一部分被分解。 具有第二前体的气溶胶被提供在等离子体的高场区的下游，并且使分解的第一材料从结构化颗粒冷凝到第二前体上。

公开(公告)号：US20140029849A1

公开(公告)日：2014-01-30

申请号：US13980230

申请日：2012-01-17

Applicant: Pradeep Sen ,  Aliakbar Darabi

Inventor： Pradeep Sen ,  Aliakbar Darabi

IPC: G06T5/00

CPC classification number: G06T5/001 ,  G06T5/00 ,  G06T5/50 ,  G06T15/503 ,  G06T2200/12 ,  G06T2207/20221

Abstract: The invention produces a higher quality image from a rendering system based on a relationship between the output of a rendering system and the parameters used to compute them. Specifically, noise is removed in rendering by estimating the functional dependency between sample features and the random inputs to the system. Mutual information is applied to a local neighborhood of samples in each part of the image. This dependency is then used to reduce the importance of certain scene features in a cross-bilateral filter, which preserves scene detail. The results produced by the invention are computed in a few minutes thereby making it reasonably robust for use in production environments.

Abstract translation: 本发明基于渲染系统的输出与用于计算它们的参数之间的关系从渲染系统产生更高质量的图像。 具体来说，通过估计样本特征与系统的随机输入之间的功能依赖性，在渲染中消除噪声。 相互信息被应用于图像的每个部分中的样本的局部邻域。 然后，这种依赖关系用于减少跨双边筛选器中某些场景特征的重要性，这保留了场景细节。 本发明产生的结果在几分钟内计算，从而使其在生产环境中的使用相当稳健。

公开(公告)号：US08637261B2

公开(公告)日：2014-01-28

申请号：US13585165

申请日：2012-08-14

Applicant: Larry A Sklar ,  Bruce Edwards ,  Frederick Kuckuck

Inventor： Larry A Sklar ,  Bruce Edwards ,  Frederick Kuckuck

IPC: G01N33/53 ,  G01N33/567 ,  G01N35/08

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。

公开(公告)号：US08609461B1

公开(公告)日：2013-12-17

申请号：US12777907

申请日：2010-05-11

Applicant: Ganesh Balakrishnan ,  Jerome V. Moloney ,  Victor Hasson

Inventor： Ganesh Balakrishnan ,  Jerome V. Moloney ,  Victor Hasson

IPC: H01L29/72

CPC classification number: H01L29/1602 ,  H01L21/02376 ,  H01L21/02546 ,  H01L21/02587 ,  H01L21/02658 ,  H01L21/02664 ,  H01L21/2007

Abstract: Various embodiments provide methods for forming a diamond heat spreader and integrating the diamond heat spreader with a heat source without generating voids at the interface. In one embodiment, a semiconductor layer can be epitaxially formed on a diamond substrate having a desirably low surface root mean square (RMS) roughness. The semiconductor epi-layer can be used as an interface layer for bonding the diamond substrate to the heat source to provide efficient heat spreading.

Abstract translation: 各种实施例提供了用于形成金刚石散热器并将金刚石散热器与热源集成而不在界面处产生空隙的方法。 在一个实施例中，可以在具有期望的低表面均方根（RMS）粗糙度的金刚石基底上外延形成半导体层。 半导体外延层可以用作将金刚石基底结合到热源的界面层，以提供有效的散热。

公开(公告)号：US08567259B1

公开(公告)日：2013-10-29

申请号：US13025031

申请日：2011-02-10

Applicant: Glenn W Ballard ,  Peter Vorobieff

Inventor： Glenn W Ballard ,  Peter Vorobieff

IPC: G01F1/32

CPC classification number: G01F1/3209

Abstract: An optical shift fluid flow velocity measurement mechanism is shown and described. A fluid flows over a bluff body to produce a vortex street. Downstream of the bluff body a light beam emission source directs a beam of light towards a lenslet including a light transmission gradient. Light transmitted through the lenslet is perceived by a photovoltaic cell which generates an electrical signal. Vortices in the vortex stream disrupt the light beam, affecting the amount of light transmitted through the lenslet and perceived by the photovoltaic cell, thereby changing the electrical signal. The frequency of the changes in the electrical signal can then be correlated to the velocity of the fluid flow.

Abstract translation: 示出并描述了光学偏移流体流速测量机构。 流体流过虚张声势的身体以产生涡街。 在非流线形体的下游，光束发射源将光束引向包括透光梯度的小透镜。 透过小透镜的光被产生电信号的光伏电池感知到。 涡流中的涡流破坏光束，影响透过小透镜并被光伏电池感知的光量，从而改变电信号。 然后电信号变化的频率可以与流体流速相关。