公开(公告)号：US09519000B2

公开(公告)日：2016-12-13

申请号：US13747945

申请日：2013-01-23

Applicant: Beckman Coulter, Inc.

Inventor： Brian D. Wilson ,  Alan N. Johnson ,  Charles S. Kraihanzel ,  Joshua D. Wiltsie

IPC: B01L3/00 ,  G01N35/04 ,  G01N35/10 ,  G01N35/00 ,  C12P19/34 ,  G05B13/02 ,  B01L7/00 ,  C12Q3/00 ,  G01F23/24 ,  G01F23/26 ,  G06F19/10 ,  C12M1/34 ,  C12Q1/68 ,  G01N1/38 ,  G01N1/31 ,  B01L3/02

CPC classification number: G01N35/04 ,  B01L3/021 ,  B01L3/0275 ,  B01L3/50825 ,  B01L3/5085 ,  B01L3/50851 ,  B01L3/52 ,  B01L3/545 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  C12M41/12 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q3/00 ,  G01F23/24 ,  G01F23/26 ,  G01N1/31 ,  G01N1/38 ,  G01N35/00732 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1016 ,  G01N35/1081 ,  G01N2035/00435 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0413 ,  G01N2035/0415 ,  G01N2035/0436 ,  G01N2035/0465 ,  G01N2035/0475 ,  G01N2035/1013 ,  G01N2035/1025 ,  G01N2035/1048 ,  G01N2035/1051 ,  G01N2035/1076 ,  G05B13/02 ,  G05B13/0205 ,  G06F19/10 ,  Y10T436/113332

Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

Abstract translation: 公开了用于处理和分析样品的系统和方法。 该系统可以使用可在不同处理位置处理的测定盒来处理样品，例如生物流体。 在某些情况下，该系统可用于PCR处理。 不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。 为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。 在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。 该系统可用于准确快速地处理样品。

公开(公告)号：US09506866B2

公开(公告)日：2016-11-29

申请号：US13960387

申请日：2013-08-06

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico ,  Thomas A. Klausing

IPC: G01N21/64 ,  G01N21/03 ,  G01N35/02 ,  B01L3/00 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1844 ,  C12M41/36 ,  G01N21/0303 ,  G01N21/0332 ,  G01N35/026 ,  G01N2021/0382 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449 ,  G01N2201/0633

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

公开(公告)号：US20160325284A1

公开(公告)日：2016-11-10

申请号：US14991844

申请日：2016-01-08

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Albert L. Camillo ,  Adrian Fawcett ,  Mike Y. Lu ,  Ian A. Harding

IPC: B01L7/00 ,  C12P19/34

CPC classification number: B01L7/52 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/50851 ,  B01L3/50853 ,  B01L9/523 ,  B01L9/56 ,  B01L2200/021 ,  B01L2200/025 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2300/022 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  C12P19/34 ,  G01N21/274 ,  G01N21/6452 ,  G01N35/028 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1037

Abstract: In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the second side. A window is positioned in the opening and a circumferential seal is positioned around a periphery of the opening at the second side. The seal has a peripheral lip that seals against the microplate. A clamp is adapted to engage and displace the frame from an unclamped position to a clamped position, wherein in the unclamped position, the microplate is displaced away from the thermocycler block and in the clamped position, the clamp urges the microplate against the thermocycler block. In some embodiments the peripheral lip is positioned radially inward of the periphery of the opening.

Abstract translation: 在高密度序列检测系统中，用于运送微孔板的装置。 控制系统提供热循环器控制信号以调节热循环器块的期望的热输出。 框架具有延伸穿过第一侧和第二侧的第一侧，第二侧和开口。 窗口定位在开口中，并且周向密封件围绕第二侧的开口的周边定位。 密封件具有密封微孔板的周边唇缘。 夹具适于将框架从未夹紧位置接合并移位到夹紧位置，其中在未夹紧位置，微孔板远离热循环器块移动，并且在夹紧位置，夹具将微孔板推向热循环器块。 在一些实施例中，外围唇缘位于开口周边的径向内侧。

公开(公告)号：US20160325043A1

公开(公告)日：2016-11-10

申请号：US15108020

申请日：2014-12-19

Applicant: William Beaumont Hospital

Inventor： Sally Ann Fisher

IPC: A61M5/178 ,  B65D51/00 ,  B01L3/00 ,  A61M5/32

CPC classification number: A61M5/1782 ,  A61M5/008 ,  A61M5/3205 ,  A61M5/3213 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0803 ,  B01L2300/0832 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/12 ,  B65D51/002 ,  B65D51/2807

Abstract: A container closure (14, 141, 142, 143, 144, 145, 146) is disclosed. The container closure (14, 141, 142, 143, 144, 145, 146) includes a fluid-drawing member (42, 421, 422, 423, 424, 425, 426) that extends axially away from and is integral with the inner surface (28I, 28I1, 28I2, 28I3, 28I4, 28I5, 28I6) of the end wall (28, 281, 282, 283, 284, 285, 286) of the container closure (14, 141, 142, 143, 144, 145, 146). A container assembly (10, 101, 102, 103, 104, 105, 106) is also disclosed. The container assembly (10, 101, 102, 103, 104, 105, 106) includes the container closure (14, 141, 142, 143, 144, 145, 146) and a container (12, 121, 122, 123, 124, 125, 126) connected to the container closure (14, 141, 142, 143, 144, 145, 146). A method for utilizing the container assembly (10, 101, 102, 103, 104, 105, 106) is also disclosed.

Abstract translation: 公开了一种容器封闭件（14,141,142,143,144,145,146）。 容器封闭件（14,141,142,143,144,145,146）包括一个流体牵引构件（42,42,42,422,423,424,425,426），其沿轴向延伸并且与内部 所述容器封闭件（14,141,142,143,144,116）的所述端壁（28,281,282,283,284,285,286）的表面（28I，28I1,28I2,28I3,28I4,28I5,28I6） 145,146）。 还公开了一种容器组件（10,101,102,103,104,105,106）。 容器组件（10,101,102,103,104,105,106）包括容器封闭件（14,141,142,143,144,145,146）和容器（12,121,122,123,124 ，125,126），其连接到所述容器封闭件（14,141,142,143,144,145,146）。 还公开了一种利用容器组件（10,101,102,103,104,105,106）的方法。

公开(公告)号：US20160282242A1

公开(公告)日：2016-09-29

申请号：US15173692

申请日：2016-06-05

Applicant: RareCyte, Inc.

Inventor： Daniel Campton ,  Joshua Nordberg ,  Steve Quarre ,  David Stewart ,  Ronald Seubert ,  Jonathan Lundt ,  Lance U'Ren ,  Jennifer Chow

IPC: G01N1/40 ,  G01N33/574 ,  B04B1/12 ,  B01L3/00

CPC classification number: G01N1/4077 ,  B01D21/262 ,  B01L3/502 ,  B01L3/50215 ,  B01L3/5635 ,  B01L9/50 ,  B01L2200/026 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2300/0672 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2400/0409 ,  B01L2400/0683 ,  B04B1/12 ,  C12Q1/24 ,  G01N33/574 ,  G01N2001/4083 ,  H01L21/2885 ,  H01L21/76873 ,  H01L21/76898 ,  H01L24/03 ,  H01L24/05 ,  H01L24/11 ,  H01L24/13 ,  H01L2224/03912 ,  H01L2224/0401 ,  H01L2224/05541 ,  H01L2224/05647 ,  H01L2224/1134 ,  H01L2224/1146 ,  H01L2224/11462 ,  H01L2224/1147 ,  H01L2224/1162 ,  H01L2224/11849 ,  H01L2224/11901 ,  H01L2224/13022 ,  H01L2224/13025 ,  H01L2224/13082 ,  H01L2224/13111 ,  H01L2224/13155 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/00012 ,  H01L2924/00014

Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A first depletion agent may be added to a vessel that contains the sample to change the density of a non-target material.

Abstract translation: 本公开涉及用于从样品中检索目标材料的装置，系统和方法。 可以将第一耗尽剂添加到含有样品的容器中以改变非目标材料的密度。

公开(公告)号：US20160271608A1

公开(公告)日：2016-09-22

申请号：US14662264

申请日：2015-03-19

Applicant: International Business Machines Corporation

Inventor： Emmanuel Delamarche ,  Yuksel Temiz

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L3/502723 ,  B01L2200/0615 ,  B01L2200/0684 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/0645 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0424 ,  B01L2400/086 ,  B01L2400/088 ,  B81C1/00

Abstract: A microfluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti-wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.

Abstract translation: 微流体装置和制造方法包括具有封闭部分的微流体通道，其包括：由润湿区域形成的液体通路; 以及沿着液体通道延伸并且与液体通路相邻的防湿区域。 防湿区域被构造成提供排气口以沿着防潮湿区域排出气体。

公开(公告)号：US09445840B2

公开(公告)日：2016-09-20

申请号：US13805322

申请日：2011-06-17

Applicant: Chao Han ,  Guoliang Huang ,  Jing Cheng

Inventor： Chao Han ,  Guoliang Huang ,  Jing Cheng

IPC: A61B17/43 ,  A61B17/435 ,  B01L3/00 ,  C12M3/00 ,  C12M3/06 ,  C12M1/00

CPC classification number: A61B17/43 ,  A61B17/435 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2300/0851 ,  B01L2400/086 ,  C12M21/06 ,  C12M23/16 ,  C12M47/04

Abstract: An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.

Abstract translation: 提供集成的微流体装置及其用途。 微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。 上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。 微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。 集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。

公开(公告)号：US20160243548A1

公开(公告)日：2016-08-25

申请号：US15029629

申请日：2014-10-16

Applicant: CLEARBRIDGE BIOMEDICS PTE LTD

Inventor： Ali Asgar Bhagat ,  Guofeng Guan

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/041 ,  B01L2300/08 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/12 ,  G01N35/10 ,  G01N2035/00158 ,  G01N2035/1034

Abstract: An interface comprising: a plurality of external ports configured to fluidically communicate with a plurality of ports of a fluidic delivery platform; and a plurality of engaging conduits configured to fluidically communicate with a plurality of ports of a microfluidic biochip, wherein a tolerance of both the plurality of external ports and/or the plurality of engaging conduits is significantly tighter than a tolerance of the plurality of ports of the microfluidic biochip.

Abstract translation: 一种接口，包括：多个外部端口，被配置为与流体传送平台的多个端口流体连通; 以及多个接合导管，其构造成与多个微流体生物芯片的多个端口流体连通，其中所述多个外部端口和/或所述多个接合导管的容许度明显地比所述多个端口 微流体生物芯片。

公开(公告)号：US09383293B2

公开(公告)日：2016-07-05

申请号：US13640393

申请日：2011-04-01

Applicant: Gert Blankenstein ,  Thanh Tu Hellmich-Duong ,  Dirk Kurowski ,  Dirk Osterloh

Inventor： Gert Blankenstein ,  Thanh Tu Hellmich-Duong ,  Dirk Kurowski ,  Dirk Osterloh

IPC: G01N1/28 ,  B01L3/00 ,  G01N33/49 ,  B29C65/54

CPC classification number: G01N1/28 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B29C65/548 ,  G01N33/491 ,  G01N33/492

Abstract: The invention relates to a device for sample separation, particularly for blood separation, in which the sample liquid is introduced into a feed device. The sample flows vertically through a separating device such as a filter or a membrane, so that sample particles are retained and separated off.The sample liquid thus separated, particularly blood plasma, is received by an inlet chamber underneath the separating device and conveyed by means of a channel in the lateral direction out of the inlet chamber.Particularly advantageously, the channel extends into the inlet chamber, the channel being formed by a recess in the base of the inlet chamber.

Abstract translation: 本发明涉及用于样品分离的装置，特别是用于血液分离的装置，其中将样品液体引入进料装置。 样品垂直通过诸如过滤器或膜的分离装置，使样品颗粒保持和分离。 由此分离的样品液体，特别是血浆，被分离装置下方的入口室接收，并且通过横向方向的通道从入口室输送。 特别有利的是，通道延伸到入口室中，通道由入口室的底部中的凹部形成。

公开(公告)号：US09370774B2

公开(公告)日：2016-06-21

申请号：US12682555

申请日：2008-10-13

Applicant: Kishore Krishna Kumar ,  Raviprakash Jayaraman ,  Sankaranand Kaipa Narasimha ,  Renjith Mahiladevi Radhakrishnan ,  Sathyadeep Viswanathan ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao ,  Manjula Jagannath ,  Shilpa Chennakrishnaiah ,  Sudip Mondal ,  Venkatakrishnan Venkataraman

Inventor： Kishore Krishna Kumar ,  Raviprakash Jayaraman ,  Sankaranand Kaipa Narasimha ,  Renjith Mahiladevi Radhakrishnan ,  Sathyadeep Viswanathan ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao ,  Manjula Jagannath ,  Shilpa Chennakrishnaiah ,  Sudip Mondal ,  Venkatakrishnan Venkataraman

IPC: C12M1/38 ,  B01L7/00 ,  B01L3/00

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L2300/0627 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2300/1805

Abstract: Instant invention is about a hand held micro PCR device comprising a LTCC micro PCR chip comprising a heater, a reaction chamber to load a sample. It also comprises a heater control to regulate the heater on basis of input received from a temperature sensor. It further has an optical system having an optical fiber to detect a fluorescence signal from the sample, and at least one communication interface to interact with other device(s).

Abstract translation: 本发明涉及一种手持式微PCR装置，其包含LTCC微PCR芯片，其包括加热器，负载样品的反应室。 它还包括加热器控制，以根据从温度传感器接收的输入来调节加热器。 它还具有光学系统，其具有用于检测来自样品的荧光信号的光纤，以及至少一个通信接口以与其他设备相互作用。