公开(公告)号：US20160325284A1

公开(公告)日：2016-11-10

申请号：US14991844

申请日：2016-01-08

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Albert L. Camillo ,  Adrian Fawcett ,  Mike Y. Lu ,  Ian A. Harding

IPC: B01L7/00 ,  C12P19/34

CPC classification number: B01L7/52 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/50851 ,  B01L3/50853 ,  B01L9/523 ,  B01L9/56 ,  B01L2200/021 ,  B01L2200/025 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2300/022 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  C12P19/34 ,  G01N21/274 ,  G01N21/6452 ,  G01N35/028 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1037

Abstract: In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the second side. A window is positioned in the opening and a circumferential seal is positioned around a periphery of the opening at the second side. The seal has a peripheral lip that seals against the microplate. A clamp is adapted to engage and displace the frame from an unclamped position to a clamped position, wherein in the unclamped position, the microplate is displaced away from the thermocycler block and in the clamped position, the clamp urges the microplate against the thermocycler block. In some embodiments the peripheral lip is positioned radially inward of the periphery of the opening.

Abstract translation: 在高密度序列检测系统中，用于运送微孔板的装置。 控制系统提供热循环器控制信号以调节热循环器块的期望的热输出。 框架具有延伸穿过第一侧和第二侧的第一侧，第二侧和开口。 窗口定位在开口中，并且周向密封件围绕第二侧的开口的周边定位。 密封件具有密封微孔板的周边唇缘。 夹具适于将框架从未夹紧位置接合并移位到夹紧位置，其中在未夹紧位置，微孔板远离热循环器块移动，并且在夹紧位置，夹具将微孔板推向热循环器块。 在一些实施例中，外围唇缘位于开口周边的径向内侧。