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    Crenolanib for treating FLT3 mutated proliferative disorders
    51.
    发明授权
    Crenolanib for treating FLT3 mutated proliferative disorders 有权
    Crenolanib用于治疗FLT3突变型增殖性疾病

    公开(公告)号：US09101624B2

    公开(公告)日：2015-08-11

    申请号：US14053011

    申请日：2013-10-14

    申请人： Arog Pharmaceuticals, LLC

    发明人： Vinay K. Jain

    IPC分类号： A61K31/4709 ,  A61K45/06

    CPC分类号： A61K31/4709 ,  A61K9/0053 ,  A61K45/06 ,  C12Y207/10001 ,  G01N33/57426 ,  G01N2333/91205 ,  A61K2300/00

    摘要： The present invention relates to the use of crenolanib, in a pharmaceutically acceptable salt form for the treatment of FLT3 mutated proliferative disorders driven by constitutively activated mutant FLT3, and to a method of treatment of warm-blooded animals, preferably humans, in which a therapeutically effective dose of crenolanib is administered to an animal suffering from said disease or condition:

    摘要翻译： 本发明涉及以药学上可接受的盐形式用于治疗由组成型激活的突变体FLT3驱动的FLT3突变增殖性疾病的格列兰尼班的用途以及治疗温血动物（优选人）的方法，其中治疗 给患有该疾病或病症的动物施用有效剂量的格伦那尼;

    DETECTING AND SORTING CELLS OR PARTICLES
    52.
    发明申请
    DETECTING AND SORTING CELLS OR PARTICLES 审中-公开
    检测和分离细胞或颗粒

    公开(公告)号：US20150219661A1

    公开(公告)日：2015-08-06

    申请号：US14171664

    申请日：2014-02-03

    申请人： Microsensor Labs, LLC.

    发明人： Peng Liu

    IPC分类号： G01N33/574 ,  G01N27/74

    CPC分类号： G01N33/57492 ,  G01N27/745 ,  G01N2333/70589 ,  G01N2333/71 ,  G01N2333/91205

    摘要： In a method of detecting target analytes, the target analytes are labeled with first magnetic beads and the contaminants are labeled with second magnetic beads, wherein the first magnetic beads have a first magnetic relaxation characteristic and the second magnetic beads have a second magnetic relaxation characteristic. A labeled target analyte or a labeled contaminant passes through a detection region one at a time. A magnetic field is applied to the detection region, thereby magnetizing the first magnetic beads in the labeled target analyte or the second magnetic beads in the labeled contaminant in the detection region. The magnetic field is then removed. The magnetic relaxation characteristics of the magnetized first magnetic beads or of the magnetized second magnetic beads are detected after the magnetic field is removed. A target analyte or a contaminant can be differentiated based on the detected magnetic relaxation characteristics.

    摘要翻译： 在检测目标分析物的方法中，目标分析物用第一磁珠标记，污染物用第二磁珠标记，其中第一磁珠具有第一磁性松弛特性，第二磁珠具有第二磁性松弛特性。 标记的目标分析物或标记的污染物一次通过检测区域。 磁场被施加到检测区域，由此磁化标记的目标分析物中的第一磁珠或检测区域中标记污染物中的第二磁珠。 然后去除磁场。 在去除磁场之后检测磁化的第一磁珠或磁化的第二磁珠的磁弛豫特性。 可以基于检测到的磁弛豫特性来区分目标分析物或污染物。

    Whole blood assay for measuring AMPK activation
    55.
    发明授权
    Whole blood assay for measuring AMPK activation 有权
    用于测量AMPK活化的全血测定

    公开(公告)号：US09005909B2

    公开(公告)日：2015-04-14

    申请号：US13333817

    申请日：2011-12-21

    申请人： Vadim Markovtsov ,  Yasumichi Hitoshi

    发明人： Vadim Markovtsov ,  Yasumichi Hitoshi

    IPC分类号： G01N33/573 ,  G01N33/49 ,  G01N33/53

    CPC分类号： G01N33/573 ,  G01N33/49 ,  G01N33/4915 ,  G01N33/5041 ,  G01N33/53 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2800/02

    摘要： A method of sample analysis is provided. In certain embodiments, the method comprises: a) labeling cells of a blood sample using an antibody that specifically binds to phospho-AMPK or a phosphorylated target thereof, to produce a labeled sample; and b) measuring antibody binding by a population of blood cells of the labeled sample using flow cytometry. In particular embodiments, the method may further comprise, prior to the labeling step: contacting blood with a test agent ex vivo or in vivo; and comparing the evaluation to results obtained from a reference sample of blood cells.

    摘要翻译： 提供了样品分析的方法。 在某些实施方案中，所述方法包括：a）使用特异性结合磷酸化AMPK或其磷酸化靶标的抗体标记血液样品的细胞，以产生标记的样品; 和b）使用流式细胞术测量标记样品的血细胞群体的抗体结合。 在具体实施方案中，该方法还可以包括在标记步骤之前：离体或体内使血液与测试试剂接触; 并将评估与从血细胞的参考样品获得的结果进行比较。