公开(公告)号：US20190211392A1

公开(公告)日：2019-07-11

申请号：US16361511

申请日：2019-03-22

申请人： Natera, Inc.

发明人： Matthew RABINOWITZ ,  George GEMELOS ,  Milena BANJEVIC ,  Allison RYAN ,  Zachary DEMKO ,  Matthew HILL ,  Bernhard ZIMMERMANN ,  Johan BANER

IPC分类号： C12Q1/6869 ,  C12Q1/6862 ,  C12Q1/6806 ,  G16B20/00 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6883

CPC分类号： C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2537/143

摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20190203290A1

公开(公告)日：2019-07-04

申请号：US16360843

申请日：2019-03-21

申请人： Natera, Inc.

发明人： Matthew RABINOWITZ ,  George GEMELOS ,  Milena BANJEVIC ,  Allison RYAN ,  Zachary DEMKO ,  Matthew HILL ,  Bernhard ZIMMERMANN ,  Johan BANER

IPC分类号： C12Q1/6869 ,  C12Q1/6862 ,  C12Q1/6806 ,  G16B20/00 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6883

CPC分类号： C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2537/143

摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20190017925A1

公开(公告)日：2019-01-17

申请号：US15703941

申请日：2017-09-13

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： JANG-MING LEE ,  I-JEN HSU ,  MAX TI-KUANG HOU ,  PEI-WEN YANG

IPC分类号： G01N21/31 ,  G06F19/00 ,  G01N33/574

CPC分类号： G01N21/31 ,  G01N33/574 ,  G01N2021/1742 ,  G01N2201/1293 ,  G01N2800/52 ,  G06F19/34 ,  G16H20/10 ,  G16H20/40 ,  G16H50/30 ,  G16H50/70

摘要： The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's tumor tissue spectra. By the features of the present invention, the prediction result achieves the sensitivity of 75% and specificity of 73.3% in concurrent chemoradiotherapy (CCRT) response; the survival prediction rate achieves the sensitivity of 100%; the recurrence prediction rate achieves the sensitivity of 85.7%.

公开(公告)号：US20180211216A1

公开(公告)日：2018-07-26

申请号：US15933578

申请日：2018-03-23

申请人： IpVenture, Inc

发明人： Chung Lau ,  C. Douglass Thomas

IPC分类号： G06Q10/08 ,  H04L29/08 ,  G06Q10/00 ,  H04W4/20 ,  H04W4/02 ,  H04W4/029 ,  H04W64/00

CPC分类号： G06Q10/0833 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/02 ,  A61B5/02055 ,  A61B5/04 ,  A61B5/1112 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/1123 ,  A61B5/6801 ,  A61B5/7282 ,  A61B5/742 ,  G06F11/3013 ,  G06F11/3055 ,  G06F11/3058 ,  G06F19/34 ,  G06F19/3418 ,  G06Q10/00 ,  G06Q10/0832 ,  G06Q10/107 ,  G06Q50/22 ,  G06Q50/24 ,  G16H50/20 ,  H04L67/04 ,  H04L67/18 ,  H04W4/02 ,  H04W4/027 ,  H04W4/029 ,  H04W4/20 ,  H04W64/00 ,  Y10S128/92

摘要： Improved approaches for monitoring status of articles being shipped are disclosed. The monitoring can produce notifications to interested parties. The notifications typically contain status information pertaining to the articles being shipped. Alternatively, interested parties can gain access to status information pertaining to the articles being shipped via a website. According to one embodiment, the status information includes at least position (location) information and shipping conditions information.

公开(公告)号：US10017812B2

公开(公告)日：2018-07-10

申请号：US13300235

申请日：2011-11-18

申请人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

发明人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC分类号： G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  C12Q1/6869 ,  C12Q1/6827 ,  G06F19/18 ,  C12Q1/6883 ,  C12Q1/6862 ,  G06F19/24

CPC分类号： C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2537/143

摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US10010291B2

公开(公告)日：2018-07-03

申请号：US14214901

申请日：2014-03-15

申请人： Abbott Diabetes Care Inc.

发明人： Erwin S. Budiman ,  Gary A. Hayter ,  Kenneth J. Doniger ,  Timothy C. Dunn ,  Nathan C. Crouther ,  Glenn H. Berman ,  Howard A. Wolpert

IPC分类号： G01N33/48 ,  A61B5/00 ,  G01N33/66 ,  A61B5/145 ,  G06F19/00 ,  G16H50/30 ,  G16H15/00

CPC分类号： A61B5/7275 ,  A61B5/14532 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  G01N33/66 ,  G06F19/00 ,  G06F19/34 ,  G06F19/3456 ,  G16H15/00 ,  G16H20/10 ,  G16H50/30 ,  G16Z99/00

摘要： A system and method provides a glucose report for determining glycemic risk based on an ambulatory glucose profile of glucose data over a time period, a glucose control assessment based on median and variability of glucose, and indicators of high glucose variability. Time of day periods are shown at which glucose levels can be seen. A median glucose goal and a low glucose line provide coupled with glucose variability provide a view into effects that raising or lowering the median goal would have. Likelihood of low glucose, median glucose compared to goal, and variability of glucose below median provide probabilities based on glucose data. Patterns can be seen and provide guidance for treatment.

公开(公告)号：US09993642B2

公开(公告)日：2018-06-12

申请号：US14775618

申请日：2014-03-14

申请人： The Regents of the University of California

发明人： Yury Gerasimenko ,  Victor Reggie Edgerton ,  Roland R. Roy ,  Daniel C. Lu

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61K31/00 ,  A61K31/197 ,  G06F19/00

CPC分类号： A61N1/36003 ,  A61K31/00 ,  A61K31/197 ,  A61N1/0456 ,  A61N1/36014 ,  A63B2213/004 ,  G06F19/34 ,  G16H20/40

摘要： In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.

公开(公告)号：US09987489B2

公开(公告)日：2018-06-05

申请号：US15340145

申请日：2016-11-01

申请人： Elwha LLC

发明人： Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Melanie K. Kitzan ,  Eric C. Leuthardt ,  Mark A. Malamud ,  Stephen L. Malaska ,  Nathan P. Myhrvold ,  Brittany Scheid ,  Katherine E. Sharadin ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： A61N1/36 ,  A61B5/053 ,  A61N7/00 ,  A61N2/00 ,  H04R25/00 ,  A61N1/04 ,  A61H23/02 ,  A61N1/372 ,  G06F19/00 ,  A63F13/424 ,  A61N2/02

CPC分类号： A61N1/36014 ,  A61B5/0077 ,  A61B5/04001 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/053 ,  A61B2017/00044 ,  A61H23/02 ,  A61H23/0236 ,  A61H23/0245 ,  A61H2201/0188 ,  A61H2201/02 ,  A61H2201/10 ,  A61H2201/1604 ,  A61H2201/165 ,  A61H2201/501 ,  A61H2201/5012 ,  A61H2201/5046 ,  A61H2201/5058 ,  A61H2201/5061 ,  A61H2201/5064 ,  A61H2201/5082 ,  A61H2201/5092 ,  A61H2201/5097 ,  A61H2205/027 ,  A61H2230/00 ,  A61H2230/045 ,  A61H2230/065 ,  A61H2230/105 ,  A61H2230/305 ,  A61H2230/405 ,  A61H2230/605 ,  A61H2230/655 ,  A61N1/0456 ,  A61N1/0472 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36036 ,  A61N1/37247 ,  A61N2/002 ,  A61N2/006 ,  A61N2/02 ,  A61N7/00 ,  A61N2007/0026 ,  A63F13/424 ,  G06F19/00 ,  G06F19/34 ,  G16H20/30 ,  G16H20/40 ,  G16H40/63 ,  H04R1/1016 ,  H04R25/606 ,  H04R25/70

摘要： Systems and related methods for controlling an ear stimulation device with a personal computing device, in response to determination of electrical contact of an electrode in a stimulator earpiece with an ear of a user of the personal computing device, are described. If the electrode is not in good electrical contact with the ear of the user, delivery of the stimulus is prevented and the user is notified of the status of the electrode. In various aspects, the user is instructed to reposition the earpiece or replace, clean, moisten, or apply gel to at least a portion of the electrode.

公开(公告)号：US09977867B2

公开(公告)日：2018-05-22

申请号：US14923043

申请日：2015-10-26

申请人： MedEncentive, LLC

发明人： Jeffrey C. Greene

IPC分类号： G06F19/00 ,  G06Q10/08 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q30/02 ,  G06Q50/20

CPC分类号： G16H10/60 ,  G06F19/00 ,  G06F19/328 ,  G06F19/34 ,  G06Q10/087 ,  G06Q10/10 ,  G06Q30/0207 ,  G06Q50/20 ,  G06Q50/22 ,  G16H40/20 ,  G16H50/20

摘要： System and method for reducing healthcare costs by improving care and encouraging healthy behaviors. A web-based or telephonic program using health plan sponsor funded financial incentives, offered to patients and providers for declaring or demonstrating adherence or providing a reason for non-adherence to performance standards. Financial incentives are contingent upon patient's and provider's agreement to allow the other to confirm or acknowledge the other's declaration or demonstration of adherence or non-adherence reason. Combining financial incentives with a set of checks and balances motivates participation in the program and adherence to the performance standards. Performance standards include evidence-based treatment guidelines, information therapy, wellness and prevention solutions, care management, and other methods proven to control costs by improving behaviors and healthcare. The system and method achieves improved health and more affordable healthcare by aligning the interests of providers, patients/consumers, and health plan sponsors in a win-win-win arrangement.

公开(公告)号：US20180073080A1

公开(公告)日：2018-03-15

申请号：US15806047

申请日：2017-11-07

申请人： Natera, Inc.

发明人： Matthew RABINOWITZ ,  George GEMELOS ,  Milena BANJEVIC ,  Allison RYAN ,  Zachary DEMKO ,  Matthew HILL ,  Bernhard ZIMMERMANN ,  Johan BANER

IPC分类号： C12Q1/68 ,  G06F19/12 ,  G06F19/18 ,  G06F19/22 ,  G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06F19/34 ,  G16B5/00 ,  G16B20/00 ,  G16B30/00 ,  G16H50/30

摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.