公开(公告)号：US3422138A

公开(公告)日：1969-01-14

申请号：US3422138D

申请日：1966-08-05

申请人： DAHLIA KIBBUTZ HASHOMER HAZAIR

发明人： HOLZMAN SUZANA ,  TIVON KIRYAT ,  MILWIDSKY BEN-ZION

IPC分类号： C07C303/28 ,  C07C303/32 ,  C07C309/08 ,  C07C309/20 ,  C11D1/14 ,  C07C143/10 ,  C07C143/68

CPC分类号： C07C303/06 ,  C07C303/28 ,  C07C303/32 ,  C07C309/20 ,  C11D1/143 ,  C07C309/68 ,  C07C309/08

公开(公告)号：US3134715A

公开(公告)日：1964-05-26

申请号：US3657660

申请日：1960-06-16

申请人： LEONARD MITCHELL

发明人： LEONARD MITCHELL

IPC分类号： A61K31/255 ,  C07C303/26 ,  C07C303/28 ,  C07C309/37 ,  C07C309/74 ,  C07C309/86

CPC分类号： C07C309/86 ,  A61K31/255 ,  C07C303/26 ,  C07C303/28 ,  C07C309/37 ,  C07C309/74 ,  C07C2601/14

公开(公告)号：US20240190816A1

公开(公告)日：2024-06-13

申请号：US18585198

申请日：2024-02-23

申请人： SANKO CO., LTD.

发明人： Ryoichi Kinishi ,  Yoshimi Ishibashi

IPC分类号： C07C309/76 ,  B41M5/323 ,  C07C303/28 ,  C07C303/30

CPC分类号： C07C309/76 ,  B41M5/323 ,  C07C303/28 ,  C07C303/30

摘要： The present invention relates to an N,N′-diarylurea derivative represented by the following general formula (1) and a method for producing the same. In addition, the present invention relates to a thermosensitive recording material in which a thermosensitive recording layer including a basic dye which is colorless or lightly colored at room temperature and a developer capable of developing color upon contact with the basic dye by heating is provided on a base sheet, wherein the developer is the N,N′-diarylurea derivative represented by the following general formula (1):




(wherein R2 is an alkyl group, an aralkyl group, or an aryl group; and Al is a hydrogen atom or an alkyl group).

公开(公告)号：US20230357137A1

公开(公告)日：2023-11-09

申请号：US17923015

申请日：2021-04-28

申请人： AMGEN INC.

发明人： Neil Fred LANGILLE ,  Jason S. TEDROW ,  Jonathan Vinh-Phu TRUONG ,  Robert Ronald MILBURN ,  Alessandro ARENA

IPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71

CPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71 ,  C07B2200/13

摘要： Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230155178A1

公开(公告)日：2023-05-18

申请号：US18099275

申请日：2023-01-20

申请人： Mitsubishi Chemical Corporation ,  MU IONIC SOLUTIONS CORPORATION

发明人： Hiroaki YOSHIDA ,  Daisuke KAWAKAMI ,  Koji FUKAMIZU

IPC分类号： H01M10/0567 ,  C07D317/36 ,  C07C303/28 ,  H01M10/052 ,  H01M10/0569 ,  E21B33/12 ,  E21B33/127 ,  E21B43/10 ,  H01M10/0525

CPC分类号： H01M10/0567 ,  C07D317/36 ,  C07C303/28 ,  H01M10/052 ,  H01M10/0569 ,  E21B33/1208 ,  E21B33/127 ,  E21B43/103 ,  H01M10/0525 ,  H01M2300/0017 ,  H01M2300/0025 ,  C07C309/65

摘要： A task is to provide a non-aqueous electrolytic solution exhibiting excellent cycle capacity maintaining ratio and excellent low-temperature resistance characteristics and a non-aqueous electrolyte secondary battery using the same. An object of the present invention is to provide a non-aqueous electrolytic solution which improves the cycle capacity maintaining ratio and low-temperature resistance characteristics, and a non-aqueous electrolyte secondary battery using the non-aqueous electrolytic solution. The present invention is a non-aqueous electrolytic solution comprising an electrolyte and a non-aqueous solvent dissolving therein the electrolyte, wherein the non-aqueous electrolytic solution contains a compound represented by formula (1) (wherein X represents an organic group containing a heteroatom, Y represents a sulfur atom, a phosphorus atom, or a carbon atom, n represents an integer of 1 or 2, m represents an integer of 2 to 4, l represents an integer of 1 or 2, and Z represents an organic group having 4 to 12 carbon atoms and optionally having a heteroatom), and a non-aqueous electrolyte secondary battery comprising the non-aqueous electrolytic solution.

公开(公告)号：US20190135742A1

公开(公告)日：2019-05-09

申请号：US16236370

申请日：2018-12-29

申请人： SOUTH CHINA AGRICULTURAL UNIVERSITY

发明人： Youzhi TANG ,  Yahong LIU ,  Zhaosheng ZHANG

IPC分类号： C07C323/63 ,  C07C303/28 ,  C07C319/14 ,  C07C319/20

CPC分类号： C07C323/63 ,  A61P31/04 ,  C07C303/28 ,  C07C309/73 ,  C07C319/14 ,  C07C319/20 ,  C07C323/52 ,  C07C2603/82

摘要： A pleuromutilin derivative having a 2-amino phenyl mercaptan side chain as well as a preparation method and application thereof are provided. The derivative has a structure represented by formula 2 or formula 3, wherein, R1, R2 and R3 are each independently selected from a hydrogen atom, hydroxyl, amino, sulfydryl, hydroxymethyl, amine methyl, nitro, halogen, trihalogenated methyl, methyl, natural amino acid acylamino and C1-6 alkoxy. The plueuromutilin derivative in the disclosure has good activity of inhibiting drug-resistant staphylococcus aureus and mycoplasma, and is especially suitable for preventing and treating infectious diseases caused by human or animal mycoplasma or drug-resistant staphylococcus aureus or multidrug resistant bacteria as a novel antibacterial drug.

公开(公告)号：US10081820B2

公开(公告)日：2018-09-25

申请号：US14837683

申请日：2015-08-27

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Miyoshi Yamashita ,  Takeshi Kinsho

IPC分类号： C12P7/62 ,  C07C69/78 ,  C07C67/08 ,  C07C303/28 ,  C07C29/80 ,  C07C67/10 ,  C07C67/54 ,  C07C29/09

CPC分类号： C12P7/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/095 ,  C07C29/80 ,  C07C67/08 ,  C07C67/10 ,  C07C67/54 ,  C07C69/78 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

摘要： Provided are methods including a method for industrially producing (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a sex pheromone of pistachio twig borer. The methods can include a production method comprising a step of reacting racemic (2RS,12Z)-2-hydroxy-12-heptadecene with vinyl benzoate in the presence of a lipase to obtain a mixture of optically active (2R,12Z)-2-benzoyloxy-12-heptadecene of Formula (R,Z-2) and optically active (2S,12Z)-2-hydroxy-12-heptadecene of Formula (S,Z-1), a step of heating the mixture to distill out the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1), and a step of acetylating the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1) to obtain optically active (2S,12Z)-2-acetoxy-12-heptadecene of Formula (S,Z-3).

公开(公告)号：US10059653B2

公开(公告)日：2018-08-28

申请号：US15541931

申请日：2016-01-19

申请人： LABORATORIO CHIMICO INTERNAZIONALE S.P.A.

发明人： Giorgio Bertolini ,  Paolangelo Cerea ,  Corrado Colli ,  Lazzaro Feliciani ,  Federico Gassa ,  Aldo Bianchi ,  Federica Colombo ,  Stefano Maiorana ,  Filippo Nisic

IPC分类号： C07C209/22 ,  C07C67/00 ,  C07C45/46 ,  C07C29/00 ,  C07C303/28 ,  C07C69/14 ,  C07C69/78 ,  C07C35/32 ,  C07C309/73 ,  C07C309/66 ,  C07C49/84

CPC分类号： C07C209/22 ,  C07C29/00 ,  C07C35/32 ,  C07C43/188 ,  C07C45/46 ,  C07C49/84 ,  C07C67/00 ,  C07C69/14 ,  C07C69/157 ,  C07C69/78 ,  C07C209/14 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C2602/08 ,  C07C211/42

摘要： Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I):

公开(公告)号：US09981887B1

公开(公告)日：2018-05-29

申请号：US15867009

申请日：2018-01-10

申请人： The United States of America, as represented by the Secretary of the Navy

发明人： Matthew Laskoski ,  Teddy M. Keller

IPC分类号： C07C2/86 ,  C07C37/62 ,  C07C303/28

CPC分类号： C07C2/868 ,  C07C37/62 ,  C07C303/28 ,  C07C2523/44 ,  C07C2523/72 ,  C07C2531/22 ,  C07C2531/24 ,  C07C39/245 ,  C07C15/54 ,  C07C309/66

摘要： A method of: reacting a dihydroxybenzene with bromine to form a bromodihydroxybenzene; reacting the bromodihydroxybenzene with trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride to form a bromotrifluoromethanesulfonatobenzene; and reacting the bromotrifluoromethanesulfonatobenzene with phenylacetylene to form a phenylethynylbenzene.

公开(公告)号：US20180065942A1

公开(公告)日：2018-03-08

申请号：US15812524

申请日：2017-11-14

申请人： ADVERIO PHARMA GMBH

发明人： Peter FEY ,  Alfons GRUNENBERG ,  Donald BIERER

IPC分类号： C07D295/104 ,  C07D295/067 ,  C07C317/04 ,  C07C309/04 ,  C07D265/30 ,  C07D471/04 ,  C07C303/28 ,  C07C309/65

CPC分类号： C07D295/104 ,  A61P9/00 ,  C07B2200/13 ,  C07C303/28 ,  C07C309/04 ,  C07C317/04 ,  C07D265/30 ,  C07D295/067 ,  C07D471/04 ,  C07C309/65

摘要： The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.