公开(公告)号：US20230167130A1

公开(公告)日：2023-06-01

申请号：US17922619

申请日：2021-05-05

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Jason S. TEDROW ,  Gabrielle ST-PIERRE ,  Oliver Ralf THIEL ,  Liang HUANG ,  Philipp C. ROOSEN ,  John T. COLYER ,  Kyle D. BAUCOM ,  Ari ERICSON ,  Matthew G. BEAVER ,  Rahul P. SANGODKAR ,  Michael A. LOVETTE ,  Robert Ronald MILBURN ,  Alan H. CHERNEY ,  Sheng CUI

IPC: C07D513/10 ,  C07D267/16

CPC classification number: C07D513/10 ,  C07D267/16

Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230357137A1

公开(公告)日：2023-11-09

申请号：US17923015

申请日：2021-04-28

Applicant: AMGEN INC.

Inventor： Neil Fred LANGILLE ,  Jason S. TEDROW ,  Jonathan Vinh-Phu TRUONG ,  Robert Ronald MILBURN ,  Alessandro ARENA

IPC: C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71

CPC classification number: C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71 ,  C07B2200/13

Abstract: Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230136910A1

公开(公告)日：2023-05-04

申请号：US17916843

申请日：2021-04-28

Applicant: AMGEN INC.

Inventor： Robert P. FARRELL ,  Jason S. TEDROW

IPC: C07D519/00 ,  C07D513/04

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound (E), wherein R1 is described herein. Compound (E) can be useful in synthesizing compound (A1), or a salt or solvate thereof, and compound (A2), or a salt of solvate thereof.