公开(公告)号：US20190135742A1

公开(公告)日：2019-05-09

申请号：US16236370

申请日：2018-12-29

Applicant: SOUTH CHINA AGRICULTURAL UNIVERSITY

Inventor： Youzhi TANG ,  Yahong LIU ,  Zhaosheng ZHANG

IPC: C07C323/63 ,  C07C303/28 ,  C07C319/14 ,  C07C319/20

CPC classification number: C07C323/63 ,  A61P31/04 ,  C07C303/28 ,  C07C309/73 ,  C07C319/14 ,  C07C319/20 ,  C07C323/52 ,  C07C2603/82

Abstract: A pleuromutilin derivative having a 2-amino phenyl mercaptan side chain as well as a preparation method and application thereof are provided. The derivative has a structure represented by formula 2 or formula 3, wherein, R1, R2 and R3 are each independently selected from a hydrogen atom, hydroxyl, amino, sulfydryl, hydroxymethyl, amine methyl, nitro, halogen, trihalogenated methyl, methyl, natural amino acid acylamino and C1-6 alkoxy. The plueuromutilin derivative in the disclosure has good activity of inhibiting drug-resistant staphylococcus aureus and mycoplasma, and is especially suitable for preventing and treating infectious diseases caused by human or animal mycoplasma or drug-resistant staphylococcus aureus or multidrug resistant bacteria as a novel antibacterial drug.