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公开(公告)号：US07635701B2
公开(公告)日：2009-12-22
申请号：US10524470
申请日：2003-08-19
申请人： Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty, legal representative , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
发明人： Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
IPC分类号： C07D239/42 , A61K31/505
CPC分类号： C07D239/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途，该疾病是由大麻素受体的活性的增加或减少直接或间接引起的。
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公开(公告)号：US20080280952A1
公开(公告)日：2008-11-13
申请号：US10597474
申请日：2005-02-01
IPC分类号： C07D405/12 , C07D211/72 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P37/00 , A61P29/00 , A61P19/02 , A61P19/00
CPC分类号： C07D213/82 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel pyridine derivatives such as compounds of the formula (I): and the use of such compounds or pharmaceutical compositions thereof in the treatment of diseases, particularly pain, which are mediated by the activity of the cannabinoid 2 receptor.
摘要翻译： 本发明涉及新的吡啶衍生物，例如式（I）的化合物：以及这些化合物或其药物组合物在治疗由大麻素2受体的活性介导的疾病，特别是疼痛中的用途。
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3.发明申请公开(公告)号：US20080132505A1
公开(公告)日：2008-06-05
申请号：US10597527
申请日：2005-02-01
申请人： Andrew James Brown , Helen Elizabeht Connor , Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , Karamjit Singh Jandu , Richard Graham Knowles , William Leonard Mitchell , Alan Naylor , Celestine Theresa O'Shaughnessy , Giovanni Palombi , Derek Anthony Rawlings , Brian Peter Slingsby , Catherine Jane Tralau-Stewart , Andrew Richard Whittington , Richard Alexander Williamson
发明人： Andrew James Brown , Helen Elizabeht Connor , Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , Karamjit Singh Jandu , Richard Graham Knowles , William Leonard Mitchell , Alan Naylor , Celestine Theresa O'Shaughnessy , Giovanni Palombi , Derek Anthony Rawlings , Brian Peter Slingsby , Catherine Jane Tralau-Stewart , Andrew Richard Whittington , Richard Alexander Williamson
IPC分类号： A61K31/505 , A61K31/5377 , A61K31/4406 , A61K31/44 , A61P37/00 , A61P29/00 , A61P25/00 , A61P11/00
CPC分类号： A61K31/505 , A61K2300/00
摘要： Combination of one or more CB2 modulators and one or more PDE4 inhibitors, and method of treating conditions which are mediated by the activity of CB2 receptors or conditions which are mediated by PDE4.
摘要翻译： 一种或多种CB2调节剂与一种或多种PDE4抑制剂的组合，以及治疗由CB2受体的活性或由PDE4介导的病症介导的病症的方法。
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公开(公告)号：US20100041654A1
公开(公告)日：2010-02-18
申请号：US12582861
申请日：2009-10-21
申请人： Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
发明人： Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
IPC分类号： C07D239/42 , A61K31/505 , A61K31/5377 , C07D413/02 , A61K31/496 , C07D401/02 , A61P29/00 , A61P19/02 , A61P19/10
CPC分类号： C07D239/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12
摘要： This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译： 这涉及新颖的嘧啶衍生物，含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途，该疾病是由大麻素受体的活性的增加或减少直接或间接引起的。
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公开(公告)号：US20080261977A1
公开(公告)日：2008-10-23
申请号：US10597521
申请日：2005-02-21
IPC分类号： A61K31/5377 , C07D239/42 , A61K31/505 , A61P29/00 , A61P37/00 , C07D413/06
CPC分类号： C07D239/42 , C07D401/12
摘要： The present invention relates to novel pyrimidine derivatives such as compounds of the formula (I) and the use of such compounds or pharmaceutical compositions thereof in the treatment of diseases, particularly pain, which are mediated by the activity of the cannabinoid 2 receptor.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，例如式（I）的化合物以及这些化合物或其药物组合物在治疗由大麻素2受体的活性介导的疾病，特别是疼痛中的用途。
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6.发明授权
公开(公告)号：US5861414A
公开(公告)日：1999-01-19
申请号：US836981
申请日：1997-05-29
IPC分类号： C07D401/04 , A61K20060101 , A61K31/415 , A61K31/4427 , A61K31/445 , A61P7/02 , C07D20060101 , C07D401/14
CPC分类号： C07D401/14
摘要： The invention provides the compounds of formula (I) ##STR1## and pharmaceutically acceptable derivatives thereof, in which: X represents either CH.sub.2 --CH.sub.2 or CH.dbd.CH, andY represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms.Compounds of formula (I) inhibit blood platelet aggregation.
摘要翻译： PCT No.PCT / EP95 / 05043 Sec。 371日期1997年5月29日 102（e）日期1997年5月29日PCT 1995年12月21日PCT PCT。 公开号WO96 / 20192 日期：1996年7月4日本发明提供式（I）化合物及其药学上可接受的衍生物，其中：X表示CH 2 -CH 2或CH = CH，Y表示氢原子或苯甲基 基团，其中苯基任选被一个或多个卤素原子取代。 式（I）化合物抑制血小板聚集。
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7.发明申请2-(Phenylamino)-Pyrimidin-5-Amides As Cannabinoid 2 Receptors Modulators for the Treatment of Immune or Inflammatory Disorders 审中-公开2-（苯基氨基） - 嘧啶-5-酰胺作为大麻素2受体调节剂治疗免疫或炎性疾病公开(公告)号：US20090264452A1
公开(公告)日：2009-10-22
申请号：US10597476
申请日：2005-02-01
申请人： Andrew John Eatherton , Gerard Martin Paul Giblin , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Ian David Wall
发明人： Andrew John Eatherton , Gerard Martin Paul Giblin , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Ian David Wall
IPC分类号： A61K31/505 , C07D239/42 , C07D405/12 , A61K31/506 , A61P29/00 , A61P37/00 , A61P19/00
CPC分类号： C07D239/42 , C07D405/12
摘要： The present invention relates to novel pyrimidine derivatives such as compounds of the formula (I): and the use of such compounds or pharmaceutical compositions thereof in the treatment of diseases, particularly pain, which are mediated by the activity of the cannabinoid 2 receptor.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，例如式（I）的化合物：以及这些化合物或其药物组合物在治疗由大麻素2受体的活性介导的疾病，特别是疼痛中的应用。
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公开(公告)号：US20090018128A1
公开(公告)日：2009-01-15
申请号：US12162824
申请日：2007-01-30
IPC分类号： C07D487/04 , A61K31/437 , A61K31/5377 , A61P29/00 , A61P19/02 , A61P19/10
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrrolopyrazine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译： 本发明涉及新型的吡咯并吡嗪衍生物，含有这些化合物的药物组合物及其用于治疗由大麻素受体的活性增加或直接引起的直接或间接引起的疾病，特别是疼痛的疾病。
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公开(公告)号：US20080221097A1
公开(公告)日：2008-09-11
申请号：US11997918
申请日：2006-08-07
申请人： Andrew John Eatherton , Gerard Martin Paul Giblin , William Leonard Mitchell , Alan Naylor , Lee William Page , Martin Swarbrick , Jennifer Anne Sweeting
发明人： Andrew John Eatherton , Gerard Martin Paul Giblin , William Leonard Mitchell , Alan Naylor , Lee William Page , Martin Swarbrick , Jennifer Anne Sweeting
IPC分类号： A61K31/5377 , C07D471/04 , A61P25/02 , A61P25/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to novel imidazopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译： 本发明涉及新颖的咪唑并吡啶衍生物，含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途，该疾病通过大麻素受体的活性的增加或减少直接或间接引起。
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公开(公告)号：US3134715A
公开(公告)日：1964-05-26
申请号：US3657660
申请日：1960-06-16
申请人： LEONARD MITCHELL
发明人： LEONARD MITCHELL
IPC分类号： A61K31/255 , C07C303/26 , C07C303/28 , C07C309/37 , C07C309/74 , C07C309/86
CPC分类号： C07C309/86 , A61K31/255 , C07C303/26 , C07C303/28 , C07C309/37 , C07C309/74 , C07C2601/14
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