公开(公告)号：US4861869A

公开(公告)日：1989-08-29

申请号：US868800

申请日：1986-05-29

Applicant: Robert A. Nicolotti ,  Richard T. Dean

Inventor： Robert A. Nicolotti ,  Richard T. Dean

IPC: C07K16/00 ,  A61K31/40 ,  A61K39/395 ,  A61K51/00 ,  A61K51/10 ,  A61P35/00 ,  C07C327/32 ,  C07D207/46 ,  C07D233/60 ,  C07D233/64 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K14/00 ,  C07K16/30 ,  C12P21/00 ,  C12P21/08 ,  G01N33/534 ,  G01N33/574

CPC classification number: C07D231/12 ,  A61K51/10 ,  A61K51/1093 ,  C07D207/46 ,  C07D233/56 ,  C07D249/08 ,  A61K2121/00 ,  A61K2123/00 ,  Y10S530/866

Abstract: This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.

公开(公告)号：US4784481A

公开(公告)日：1988-11-15

申请号：US897759

申请日：1986-08-13

Applicant: Volker Wuerfel

Inventor： Volker Wuerfel

IPC: G02B21/26 ,  A61K51/00 ,  A61K51/04 ,  A61K51/10 ,  C01G99/00 ,  F22B21/26 ,  F24H1/43 ,  F24H8/00 ,  F24H9/00 ,  G02B21/00 ,  G02B21/08 ,  G02B21/24 ,  H01L21/66 ,  G02B21/20

CPC classification number: A61K51/10 ,  A61K51/0476 ,  A61K51/1045 ,  A61K51/1093 ,  G02B21/088 ,  G02B21/24 ,  A61K2123/00

Abstract: Transmitted-light and/or reflected-light microscope in closed or open vertical-frame stand design (1; 2) having a vertical object stage plane (5) and a horizontal optical microscope axis (7) which is perpendicular to the object stage (5). An alternative embodiment of the microscope casing comprises at least two vertical stand parts (11; 12) which are connected together by a stand plate (13) and--as seen by the observer (47)--are arranged one behind the other. A vertical object stage (5), to which the horizontally-extending optical axis (7) is perpendicular, is located between the two stand parts (11; 12). The angular deflection .alpha. between the vertical plane (63) and the object stage plane, and thus the angular deflection between the horizontal and the optical axis (7), can be up to 30.degree. in both versions, according to the condition: 0.degree..ltoreq..alpha..ltoreq.30.degree.. In all embodiments, contamination-free handling and inspection of large-surface-area objects (6), particularly wafers, is achieved by the establishment of a laminar flow, acting in the region of the object. The observer (47) can carry out all necessary microexamination and handling functions from ergonomically-designed control panels (45, 55), which are all located outside of the critical object region on the instrument. The instrument system can be employed in fully-automated, in-process computer-controlled wafer inspection, measuring and handling lines as a central component.

Abstract translation: PCT No.PCT / DE85 / 00526 Sec。 371日期1986年8月13日 102（e）日期1986年8月13日PCT提交1985年12月14日PCT公布。 出版物WO86 / 03847 日期：1986年7月3日。具有垂直物镜平面（5）和水平光学显微镜轴（7）的封闭或开放的垂直框架架设计（1; 2）中的透射光和/或反射光显微镜 垂直于物体台（5）。 显微镜外壳的替代实施例包括至少两个垂直支架部分（11; 12），它们由支撑板（13）连接在一起，并且由观察者（47）所看到 - 布置成彼此靠近。 水平延伸的光轴（7）垂直于其的垂直物体台（5）位于两个支架部分（11; 12）之间。 根据以下条件，垂直平面（63）和物镜平面之间的角度偏转α（水平和光轴（7））之间的角度偏差可以在两个版本中高达30°

公开(公告)号：US11970522B2

公开(公告)日：2024-04-30

申请号：US17006219

申请日：2020-08-28

Applicant: The University of British Columbia

Inventor： Neil R. Cashman ,  Steven S. Plotkin

IPC: C07K7/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/17 ,  A61K39/00 ,  A61K47/64 ,  A61K51/10 ,  A61P25/28 ,  C07K5/113 ,  C07K5/117 ,  C07K7/64 ,  C07K14/00 ,  C07K14/47 ,  C07K16/18 ,  G01N33/68 ,  A61K38/05 ,  A61K38/07 ,  A61K39/385 ,  A61K39/39 ,  A61K39/395 ,  A61K45/00 ,  A61K45/06 ,  A61K47/68 ,  A61K47/69 ,  A61K49/18 ,  A61K51/08 ,  A61L27/22 ,  A61L27/34 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K16/00 ,  G01N33/50

CPC classification number: C07K14/4711 ,  A61K39/0008 ,  A61K47/643 ,  A61K47/646 ,  A61K51/1018 ,  A61P25/28 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/64 ,  C07K16/18 ,  G01N33/6896 ,  A61K38/00 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/12 ,  A61K39/00 ,  A61K39/0007 ,  A61K39/385 ,  A61K39/39 ,  A61K39/395 ,  A61K39/39533 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/6081 ,  A61K45/05 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6921 ,  A61K49/1818 ,  A61K51/088 ,  A61K51/10 ,  A61K2300/00 ,  A61L27/227 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07K5/101 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K16/00 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  G01N33/5058 ,  G01N2333/4709 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/387

Abstract: The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

公开(公告)号：US20180113140A1

公开(公告)日：2018-04-26

申请号：US15793410

申请日：2017-10-25

Applicant: Robert P. Doyle

Inventor： Robert P. Doyle

IPC: G01N33/68 ,  A61K51/10 ,  G01N33/92

CPC classification number: G01N33/6893 ,  A61B3/00 ,  A61K51/10 ,  G01N33/92 ,  G01N2800/164

Abstract: An assay and kit for detecting N-retinylidene-N-retinylethanolamine (A2E) in a sample that uses a lipid binding protein, such as Saposin B, to capture A2E in the sample and assist in the extraction and measurement of A2E via mass spectroscopy. A2E thus serves as a marker for macular degeneration so that the assay and kit of the invention can be used to detect the presence or severity of macular degeneration.

公开(公告)号：US20180036441A1

公开(公告)日：2018-02-08

申请号：US15663951

申请日：2017-07-31

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  GENUS ONCOLOGY, LLC

Inventor： Donald W. KUFE ,  Surender KHARBANDA

IPC: A61K51/10 ,  A61K39/395

CPC classification number: A61K51/10 ,  A61K39/395 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.

公开(公告)号：US09782500B2

公开(公告)日：2017-10-10

申请号：US14915134

申请日：2014-09-24

Applicant: Oncoinvent AS

Inventor： Tina Bjørnlund Bønsdorff ,  Roy Hartvig Larsen

IPC: A61K51/10 ,  C07K16/30 ,  C07K16/00 ,  C07K16/28 ,  A61K45/06 ,  A61K39/00

CPC classification number: A61K51/1045 ,  A61K45/06 ,  A61K51/10 ,  A61K51/1027 ,  A61K51/1051 ,  A61K51/1066 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2821 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3053 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/534

Abstract: The present invention relates to a novel anti-CD146 antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

公开(公告)号：US20170281807A1

公开(公告)日：2017-10-05

申请号：US15504512

申请日：2015-08-24

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： Jonathan S. WALL ,  Stephen J. KENNEL ,  James S. FOSTER

IPC: A61K51/10 ,  G01N33/68 ,  G01N33/53 ,  A61K39/395 ,  C07K16/18

CPC classification number: A61K39/39583 ,  A61K38/1716 ,  A61K39/395 ,  A61K47/66 ,  A61K47/6891 ,  A61K51/10 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/4711 ,  C07K16/18 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/70 ,  G01N33/53 ,  G01N33/6896 ,  G01N2333/4709

Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.

公开(公告)号：US09731036B2

公开(公告)日：2017-08-15

申请号：US14287901

申请日：2014-05-27

Applicant: Gal Markel

Inventor： Gal Markel

IPC: A01N63/00 ,  A61K48/00 ,  A61K51/10 ,  A61K49/00 ,  C07K16/30 ,  G01N33/569 ,  G01N33/574 ,  A61K38/17 ,  A61K35/17 ,  C07K14/705 ,  C12N5/0781 ,  C12N5/0783 ,  A61K51/04 ,  A61K51/08 ,  A61K35/12

CPC classification number: A61K51/10 ,  A61K35/17 ,  A61K38/1774 ,  A61K49/0004 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/04 ,  A61K51/088 ,  A61K2035/122 ,  C07K14/70503 ,  C07K16/3007 ,  C07K2317/54 ,  C07K2317/732 ,  C12N5/0635 ,  C12N5/0636 ,  G01N33/56972 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/70596

Abstract: The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the supression of immune responses in a targeted fashion, by increasing the functional concentration of the CEACAM1 protein in a target tissue to create a localized protective immunity for the treatment of autoimmune diseases and diseases requiring the transplantation of tissue.

公开(公告)号：US09642926B2

公开(公告)日：2017-05-09

申请号：US13822927

申请日：2011-09-26

Applicant: Les Oppenheimer ,  Ismayil M. Guracar

Inventor： Les Oppenheimer ,  Ismayil M. Guracar

IPC: A61K9/00 ,  A61K49/22 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/04 ,  B82Y5/00 ,  A61K49/08 ,  A61K49/16 ,  A61K51/10 ,  A61K31/00

CPC classification number: A61K49/221 ,  A61K31/00 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6891 ,  A61K47/6898 ,  A61K47/6925 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/16 ,  A61K49/223 ,  A61K49/227 ,  A61K51/0495 ,  A61K51/10 ,  B82Y5/00

Abstract: Compositions useful for target detection, imaging and treatment, as well as methods of production and use thereof, are disclosed herein.

公开(公告)号：US09562092B2

公开(公告)日：2017-02-07

申请号：US14932174

申请日：2015-11-04

Applicant: True North Therapeutics, Inc.

Inventor： Peter Van Vlasselaer ,  Graham Parry ,  Nancy E. Stagliano ,  Sandip Panicker

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/40 ,  A01N1/02 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/18 ,  A01N1/021 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  A61K2039/505 ,  A61K2039/54 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C12Y304/21042 ,  G01N33/6893 ,  G01N2800/52

Abstract: The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.

Abstract translation: 本公开提供了结合补体C1s蛋白的抗体; 和编码这种抗体的核酸分子。 本公开还提供了包含此类抗体的组合物，以及产生和使用此类抗体，核酸分子和组合物的方法。