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    A METHOD OF ADMINISTERING A NANOPARTICLE
    2.
    发明公开
    A METHOD OF ADMINISTERING A NANOPARTICLE 审中-公开

    公开(公告)号：US20230145172A1

    公开(公告)日：2023-05-11

    申请号：US17907029

    申请日：2021-03-19

    Applicant: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

    Inventor： Daniel GONZALEZ CARTER ,  Kazunori KATAOKA

    IPC: A61K47/69 ,  A61K47/68

    CPC classification number: A61K47/6907 ,  A61K47/6849 ,  A61K47/6898

    Abstract: A method of administering a nanoparticle to a subject including: administering to the subject an effective amount of an antibody that binds to an antigen expressed on a surface of a brain endothelial cell such that a sufficient amount of the antibody can bind to the surface of the brain endothelial cell, where the antibody is conjugated to a 1st molecule. Then administering to the subject a nanoparticle that is coated with a 2nd molecule that binds to the 1st molecule under a physiological condition in a brain blood vessel such that the nanoparticle can bind to the 1st molecule that has attached to the surface of the brain endothelial cell.

    Methods of Targeting T-Cells to Tumors
    6.
    发明申请
    Methods of Targeting T-Cells to Tumors 审中-公开
    靶向T细胞到肿瘤的方法

    公开(公告)号：US20140271687A1

    公开(公告)日：2014-09-18

    申请号：US13838667

    申请日：2013-03-15

    Applicant: Imre KOVESDI ,  Tibor BAKÁCS ,  Miklós SZABÓ

    Inventor： Imre KOVESDI ,  Tibor BAKÁCS ,  Miklós SZABÓ

    IPC: A61K47/48

    CPC classification number: A61K47/48746 ,  A61K47/48615 ,  A61K47/4863 ,  A61K47/48638 ,  A61K47/48753 ,  A61K47/6863 ,  A61K47/6867 ,  A61K47/6869 ,  A61K47/6898

    Abstract: The invention provides a method of targeting T-cells to tumor cells using a tumor-associated antigen (TAA) specific antibody and a T-cell specific antibody, wherein the two antibodies can bind to each other through a high affinity avidin/biotin or streptavidin/biotin connection. The invention further provides methods to target activated T-cells to different tumor types by using a T-cell specific antibody that is specific to an activated T-cell surface molecule like CTLA-4.

    Abstract translation: 本发明提供了使用肿瘤相关抗原（TAA）特异性抗体和T细胞特异性抗体将T细胞靶向肿瘤细胞的方法，其中两种抗体可以通过高亲和素亲和素/生物素或链霉抗生物素蛋白 /生物素连接。 本发明还提供了通过使用对活化的T细胞表面分子如CTLA-4特异性的T细胞特异性抗体来将活化的T细胞靶向不同肿瘤类型的方法。

    Specifically targeted catalytic antagonists and uses thereof
    8.
    发明授权
    Specifically targeted catalytic antagonists and uses thereof 失效
    特异性靶向催化拮抗剂及其用途

    公开(公告)号：US08431121B2

    公开(公告)日：2013-04-30

    申请号：US12953378

    申请日：2010-11-23

    Applicant: Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Sanford ,  David Aaron Estell

    Inventor： Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Sanford ,  David Aaron Estell

    IPC: A61K38/48

    CPC classification number: B82Y5/00 ,  A61K47/51 ,  A61K47/665 ,  A61K47/6898

    Abstract: This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

    Abstract translation: 本发明提供作为靶分子的催化拮抗剂的嵌合分子。 本发明的催化拮抗剂优选包含与降解由靶向部分特异性结合的分子的酶连接的靶向部分。 因此，本发明的催化拮抗剂与靶向部分识别的靶（例如受体）结合，嵌合体的酶组分然后降解靶的全部或部分。 这通常导致靶的活性降低或丧失，并释放嵌合分子。 然后嵌合分子可以自由地攻击和降解另一个靶分子。

    Embryo modification and implantation
    9.
    发明授权
    Embryo modification and implantation 有权
    胚修改和植入

    公开(公告)号：US07819796B2

    公开(公告)日：2010-10-26

    申请号：US10510377

    申请日：2003-04-07

    Applicant: Deborah A. Blake ,  Nicola L. Carter ,  Stephen M. Henry

    Inventor： Deborah A. Blake ,  Nicola L. Carter ,  Stephen M. Henry

    IPC: A61B17/435

    CPC classification number: C12N15/8775 ,  A61K47/557 ,  A61K47/665 ,  A61K47/6898 ,  A61K47/6901 ,  B82Y5/00 ,  C12N5/0006 ,  C12N5/0604

    Abstract: The present invention relates to constructs and methods used to enhance the attachment and implantation of an embryo. It is shown that modified glycolipids and glycolipid-attachment molecule constructs can be used to modify embryos, or localised to target tissues, to enhance interaction between the embryo and the target tissue, (typically the endometrium). The invention may advantageously be used to enhance implantation of embryos in the uterus, for example, in IVF treatments.

    Abstract translation: 本发明涉及用于增强胚胎的附着和植入的构造和方法。 显示改性的糖脂和糖脂附着分子构建体可用于修饰胚胎或定位于靶组织，以增强胚胎和靶组织（通常为子宫内膜）之间的相互作用。 本发明可有利地用于增强胚胎在子宫中的植入，例如在IVF处理中。

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