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    SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF
    1.
    发明申请
    SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF 失效
    特异性靶向催化拮抗剂及其用途

    公开(公告)号：US20110262419A1

    公开(公告)日：2011-10-27

    申请号：US12953378

    申请日：2010-11-23

    Applicant: Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Stanford ,  David Aaron Estell

    Inventor： Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Stanford ,  David Aaron Estell

    IPC: A61K38/48 ,  A61P29/00 ,  A61P37/00 ,  A61P31/12 ,  A61P31/04

    CPC classification number: B82Y5/00 ,  A61K47/51 ,  A61K47/665 ,  A61K47/6898

    Abstract: This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

    Abstract translation: 本发明提供作为靶分子的催化拮抗剂的嵌合分子。 本发明的催化拮抗剂优选包含与降解由靶向部分特异性结合的分子的酶连接的靶向部分。 因此，本发明的催化拮抗剂与靶向部分识别的靶（例如受体）结合，嵌合体的酶组分然后降解靶的全部或部分。 这通常导致靶的活性降低或丧失，并释放嵌合分子。 然后嵌合分子可以自由地攻击和降解另一个靶分子。

    Specifically targeted catalytic antagonists and uses thereof
    3.
    发明授权
    Specifically targeted catalytic antagonists and uses thereof 失效
    特异性靶向催化拮抗剂及其用途

    公开(公告)号：US08431121B2

    公开(公告)日：2013-04-30

    申请号：US12953378

    申请日：2010-11-23

    Applicant: Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Sanford ,  David Aaron Estell

    Inventor： Benjamin G. Davis ,  John Bryan Jones ,  Richard R. Bott ,  Karl John Sanford ,  David Aaron Estell

    IPC: A61K38/48

    CPC classification number: B82Y5/00 ,  A61K47/51 ,  A61K47/665 ,  A61K47/6898

    Abstract: This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

    Abstract translation: 本发明提供作为靶分子的催化拮抗剂的嵌合分子。 本发明的催化拮抗剂优选包含与降解由靶向部分特异性结合的分子的酶连接的靶向部分。 因此，本发明的催化拮抗剂与靶向部分识别的靶（例如受体）结合，嵌合体的酶组分然后降解靶的全部或部分。 这通常导致靶的活性降低或丧失，并释放嵌合分子。 然后嵌合分子可以自由地攻击和降解另一个靶分子。

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