公开(公告)号：US11690820B2

公开(公告)日：2023-07-04

申请号：US17457126

申请日：2021-12-01

申请人： Amarin Pharmaceuticals Ireland Limited

发明人： Ian Osterloh ,  Pierre Wicker ,  Rene Braeckman ,  Paresh Soni ,  Mehar Manku

IPC分类号： A61K31/202 ,  A61K45/06 ,  A61K31/222 ,  A61K31/232 ,  A61K31/40 ,  A61K31/505 ,  A61K9/48 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K31/74 ,  A61P3/06

CPC分类号： A61K31/202 ,  A61K9/48 ,  A61K31/222 ,  A61K31/232 ,  A61K31/40 ,  A61K31/505 ,  A61K45/06 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K31/74 ,  A61P3/06 ,  A61K31/202 ,  A61K2300/00

摘要： The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.

公开(公告)号：US11672832B2

公开(公告)日：2023-06-13

申请号：US16467154

申请日：2017-12-08

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Jianping Fu ,  Deborah Gumucio ,  Yue Shao ,  Kenichiro Taniguchi ,  Yi Zheng ,  Sajedeh Nasr Esfahani

IPC分类号： A61K35/545 ,  C12N5/073 ,  A61K31/74 ,  A61K35/50 ,  C12N5/00 ,  G01N33/50

CPC分类号： A61K35/545 ,  A61K31/74 ,  A61K35/50 ,  C12N5/0068 ,  C12N5/0605 ,  G01N33/5044 ,  C12N2502/45 ,  C12N2533/30

摘要： The present disclosure provides compositions and methods employing stem cell-derived amnion tissue. In some embodiments, compositions (e.g., scaffolds and devices) and methods of generating amnion-like tissues from hPSCs are provided. In some embodiments, uses of such cells for research, compound screening and analysis, and therapeutics are provided.

公开(公告)号：US20230085710A1

公开(公告)日：2023-03-23

申请号：US17988625

申请日：2022-11-16

申请人： Highlight Therapeutics, S.L.

发明人： MARISOL QUINTERO ORTIZ ,  Mercedes Pozuelo Rubio ,  Lourdes Planelles Carazo

IPC分类号： A61K31/713 ,  A61K47/50 ,  A61K9/00 ,  A61K9/08 ,  C07K16/28 ,  A61K47/26 ,  A61K31/15 ,  A61K47/69 ,  A61K31/74 ,  A61K9/19

摘要： The present invention relates to compositions comprising polyinosinic (poly(I))-polycytidylic acid poly(C) molecules, or a salt and/or solvate thereof, comprising double-stranded polyribonucleotides. The present invention further relates to compositions wherein the disclosed respective poly(I) and poly(C) single-stranded molecules are annealed to thereby form double-stranded poly(I:C) molecules.

公开(公告)号：US11484591B2

公开(公告)日：2022-11-01

申请号：US16078860

申请日：2017-02-22

申请人： OHIO STATE INNOVATION FOUNDATION ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Susan Regina Mallery ,  Steven Paul Schwendeman

IPC分类号： A61K39/395 ,  A61K31/565 ,  A61K31/167 ,  A61K45/00 ,  A61K47/10 ,  A61K31/74 ,  C07K16/28 ,  A61P35/00 ,  A61K39/00

摘要： The present disclosure is directed to formulations and methods for treatment of disease such as chemoprevention of cancer, for example oral squamous cell carcinoma (OSCC), and for methods of preparing the formulations. Further, the disclosure relates to local administration in slow release dosage forms for treatment of disease. The extended-release formulations are comprised of biodegradable polymeric implants (for example millicylinders and microspheres as well as in situ forming gels) and therapeutic agents selected from an anti-interleukin 6 agent, a synthetic vitamin A analogue and/or metabolite, and/or an estradiol metabolite for the local delivery of therapeutic agents to a site where a cancer has been previously excised or to prevent progression of a precancerous lesion.

公开(公告)号：US11369578B2

公开(公告)日：2022-06-28

申请号：US17013024

申请日：2020-09-04

申请人： BlueWillow Biologics, Inc.

发明人： Susan Ciotti

IPC分类号： A61K31/74 ,  A61K31/14 ,  A61K47/44 ,  A61K9/00 ,  A61K9/107 ,  A61K31/34 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/53 ,  A61K31/685 ,  A61K31/7064 ,  A61K38/21 ,  A61K45/06 ,  A61K47/26 ,  A61K47/34 ,  A61P31/14

摘要： The present disclosure relates to nanoemulsion compositions with certain surfactant blend ratios that impart enhanced permeability. Such compositions are useful for topical, mucosal and intranasal applications and allow for the greater delivery of one or more active agents to the application site to prevent infection by a microorganism.

公开(公告)号：US20220125828A1

公开(公告)日：2022-04-28

申请号：US17557108

申请日：2021-12-21

申请人： TRIMPH IP PTY LIMITED

发明人： Ali Fathi ,  Fariba Dehghani

IPC分类号： A61K31/74 ,  A61K47/58 ,  A61K47/59 ,  A61K47/61 ,  A61K47/69 ,  A61K47/60 ,  A61K31/78 ,  A61L27/16 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

摘要： According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety: the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

公开(公告)号：US20210402015A1

公开(公告)日：2021-12-30

申请号：US17409578

申请日：2021-08-23

申请人： Kodiak Sciences Inc.

发明人： Stephen A. CHARLES ,  Daniel Victor PERLROTH ,  Didier G. BENOIT ,  Lane A. CLIZBE ,  Wayne TO ,  Linda J. ZADIK ,  Jeanne M. PRATT

IPC分类号： A61K51/06 ,  C08F230/02 ,  A61K47/58 ,  A61K31/74 ,  A61K47/68 ,  C08F2/50 ,  C08F2/06 ,  C08F20/26 ,  C08F2/04 ,  C08F20/18 ,  A61K49/00

摘要： The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.

公开(公告)号：US11007215B2

公开(公告)日：2021-05-18

申请号：US16721760

申请日：2019-12-19

申请人： OUROTECH, INC.

发明人： Duleeka Nimantha Bandara Ranatunga ,  Andrew Christopher Wenger ,  Zhi Yuan (William) Lin

IPC分类号： C08J3/075 ,  A61K31/74 ,  A61L27/20 ,  A61L27/52 ,  A61L31/04 ,  C08J3/24 ,  C08K5/1545 ,  C08L5/04 ,  C08L5/08 ,  C08K5/00 ,  A61K9/00 ,  A61K31/724 ,  A61K38/02 ,  A61K47/22 ,  A61K47/26

摘要： A shear-thinning hydrogel composition includes: a first polymer chain including: (i) a first plurality of units each having at least one of a monosaccharide and an amino acid; and (ii) a cross-linking group bound to the at least one of the monosaccharide and the amino acid of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; a second polymer chain including a second plurality of the units; and a cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group.

公开(公告)号：US10967001B2

公开(公告)日：2021-04-06

申请号：US16018603

申请日：2018-06-26

申请人： CytoSorbents Corporation

发明人： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC分类号： A61K31/745 ,  A61K31/74 ,  A61K31/75 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08F212/36 ,  C08J9/26 ,  A61K47/58

摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：US20210038634A1

公开(公告)日：2021-02-11

申请号：US16980063

申请日：2019-03-12

申请人： KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

发明人： Kazunori KATAOKA ,  Shigehito OSAWA ,  Satoshi UCHIDA ,  Kotaro HAYASHI ,  Anjaneyulu DIRISALA ,  Kazuko TOH

IPC分类号： A61K31/74 ,  A61K31/25 ,  A61K47/00

摘要： The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.