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公开(公告)号：US11883424B2
公开(公告)日：2024-01-30
申请号：US17084995
申请日：2020-10-30
IPC分类号： A61K31/713 , A61K9/00 , A61K9/08 , A61K9/19 , C07K16/28 , A61K47/69 , A61K47/26 , A61K47/50 , A61K31/15 , A61K31/74
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/15 , A61K31/74 , A61K47/26 , A61K47/50 , A61K47/6935 , C07K16/2818 , C07K16/2827
摘要： The present invention relates to compositions comprising complexes that are formed by polyinosinic-polycytidylic acid with a polyalkyleneimine, such as polyethyleneimine, that present uniform structural and functional features, as well as to methods for preparing the compositions that comply with regulatory requirements. The present invention additionally relates to use of said compositions as medicaments (in particular for treating cancer), alone or in combination with other therapeutic agents and/or in specific medical methods. Moreover, the administration of these compositions is associated to changes in the expression of specific genes, in cell responses, and/or in composition of immune cell populations that can be used as specific biomarkers and/or as additional target for medical treatment.
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公开(公告)号：US11896606B2
公开(公告)日：2024-02-13
申请号：US17095059
申请日：2020-11-11
IPC分类号： A61K31/713 , A61K9/00 , A61K9/08 , A61K9/19 , C07K16/28 , A61K47/69 , A61K47/26 , A61K47/50 , A61K31/15 , A61K31/74
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/15 , A61K31/74 , A61K47/26 , A61K47/50 , A61K47/6935 , C07K16/2818 , C07K16/2827
摘要： The present invention relates to compositions comprising particles, each of the respective particles comprising particles formed by polyribonucleotides and polymers. Specifically, the composition comprises a complex of at least one double-stranded polyribonucleotide, such as polyinosinic-polycytidylic acid [poly(I:C)], and at least one linear polyalkyleneimine. The particles are also characterized by their monomodal diameter distribution and z-average diameter within specific ranges. The present invention additionally relates to methods of manufacturing the compositions, and further to related pharmaceutical compositions useful for the treatment of any cell growth disorder characterized by an abnormal growth of human or animal cells.
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公开(公告)号：US20230085710A1
公开(公告)日：2023-03-23
申请号：US17988625
申请日：2022-11-16
IPC分类号： A61K31/713 , A61K47/50 , A61K9/00 , A61K9/08 , C07K16/28 , A61K47/26 , A61K31/15 , A61K47/69 , A61K31/74 , A61K9/19
摘要： The present invention relates to compositions comprising polyinosinic (poly(I))-polycytidylic acid poly(C) molecules, or a salt and/or solvate thereof, comprising double-stranded polyribonucleotides. The present invention further relates to compositions wherein the disclosed respective poly(I) and poly(C) single-stranded molecules are annealed to thereby form double-stranded poly(I:C) molecules.
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