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    Inhibitors of Kynurenine Aminotransferase and Uses Therefor
    21.
    发明申请
    Inhibitors of Kynurenine Aminotransferase and Uses Therefor 审中-公开
    犬尿氨酸转移酶抑制剂及其用途

    公开(公告)号：US20110144064A1

    公开(公告)日：2011-06-16

    申请号：US12085931

    申请日：2006-11-30

    申请人： Robert Schwarcz ,  Roberto Pellicciari ,  Timothy Gately

    发明人： Robert Schwarcz ,  Roberto Pellicciari ,  Timothy Gately

    IPC分类号： A61K31/662 ,  C12N5/071 ,  A61K31/197 ,  A61K31/19 ,  G01N33/50 ,  C07C53/08 ,  C07C55/02 ,  C07C309/63 ,  C07F9/38 ,  A61P25/00

    CPC分类号： A61K31/131 ,  A61K31/185 ,  Y10T436/163333 ,  Y10T436/173845 ,  Y10T436/182 ,  Y10T436/201666

    摘要： Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R1 is H, NH2 or NHCH3, R2 is H or CH3, n is 0 to 14, and X is —COOH, CH2OH, —PO3H2, —SO3H, or —SO3H; or a pharmacologically acceptable salt.

    摘要翻译： 本文提供了降低细胞中犬尿酸水平和治疗与受试者中犬尿酸增加相关的受试者的病理生理状况的方法。 在这些方法中，二羧酸或其衍生物或类似物的抑制作用对抑制犬尿氨酸氨基转移酶II的活性是有效的。 还提供了筛选针对犬尿氨酸氨基转移酶II的潜在抑制性化合物的方法。 二羧酸或其衍生物或类似物可具有结构式，其中R 1为H，NH 2或NHCH 3，R 2为H或CH 3，n为0至14，X为-COOH，CH 2 OH，-PO 3 H 2，-SO 3 H或 -SO 3 H; 或药理学上可接受的盐。

    CALCIUM RECEPTOR ACTIVATOR
    23.
    发明申请
    CALCIUM RECEPTOR ACTIVATOR 有权
    钙受体激活剂

    公开(公告)号：US20090239808A1

    公开(公告)日：2009-09-24

    申请号：US12117041

    申请日：2008-05-08

    申请人： Takeaki Ohsu ,  Sen Takeshita ,  Yuzuru Eto ,  Yusuke Amino

    发明人： Takeaki Ohsu ,  Sen Takeshita ,  Yuzuru Eto ,  Yusuke Amino

    IPC分类号： A61K38/06 ,  C07K5/093 ,  C07C55/02

    CPC分类号： A61K38/06 ,  A61K38/05

    摘要： A calcium receptor activator and compositions containing at least one of the following: γ-Glu-Cys-Gly, γ-Glu-Cys(SNO)-Gly, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, γ-Glu-Met(O), γ-Glu-Val-Val, γ-Glu-Val-Glu, γ-Glu-Val-Lys, γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-allyl)-Gly, γ-Glu-Gly-Gly, γ-Glu-Val-Phe, γ-Glu-Val-Ser, γ-Glu-Val-Pro, γ-Glu-Val-Arg, γ-Glu-Val-Asp, γ-Glu-Val-Met, γ-Glu-Val-Thr, γ-Glu-Val-His, γ-Glu-Val-Asn, γ-Glu-Val-Gln, γ-Glu-Val-Cys, γ-Glu-Val-Orn, γ-Glu-Ser-Gly, γ-Glu-Cys(S-Me), γ-Glu-Abu-Gly, γ-Glu-Cys(S-Me)-Gly, and γ-Glu-Val-Gly.

    摘要翻译： 钙受体激活剂和含有以下至少一种的组合物：γ-Glu-Cys-Gly，γ-Glu-Cys（SNO）-Gly，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Cys ，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，D -Cys，γ-Glu-Met（O），γ-Glu-Val-Val，γ-Glu-Val-Glu，γ-Glu-Val-Lys，γ-Glu-γ-Glu-Val， Val-NH2，γ-Glu-Val-ol，γ-Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu， γ-Glu-t-Leu，γ-Glu-Cys（S-烯丙基）-Gly，γ-Glu-Gly-Gly，γ-Glu-Val-Phe，γ-Glu-Val-Ser， -Pro，γ-Glu-Val-Arg，γ-Glu-Val-Asp，γ-Glu-Val-Met，γ-Glu-Val-Thr，γ-Glu-Val-His， ，γ-Glu-Val-Gln，γ-Glu-Val-Cys，γ-Glu-Val-Orn，γ-Glu-Ser-Gly，γ-Glu-Cys（S-Me） Gly，γ-Glu-Cys（S-Me）-Gly和γ-Glu-Val-Gly。

    Ionic Viscoelastics and Viscoelastic Salts
    24.
    发明申请
    Ionic Viscoelastics and Viscoelastic Salts 有权
    离子粘弹性和粘弹性盐

    公开(公告)号：US20090176956A1

    公开(公告)日：2009-07-09

    申请号：US12297756

    申请日：2007-04-20

    申请人： Mark W. Grinstaff ,  Michel Wathier

    发明人： Mark W. Grinstaff ,  Michel Wathier

    IPC分类号： C08F20/44 ,  C07C55/02 ,  C07F9/28

    CPC分类号： C07C229/24 ,  C07C59/305 ,  C07C211/09 ,  C07C211/14 ,  C07D403/12 ,  C07F9/28 ,  C07F9/5407 ,  C08F120/06 ,  C08F236/12 ,  C08G65/00 ,  C08L33/08 ,  C08L33/14 ,  C08L35/06 ,  C08L43/02 ,  C10N2220/04 ,  C08L2666/04 ,  C08L2666/02

    摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.

    摘要翻译： 本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。 本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。 在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。 在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体 晶体，生物相容性流体，溶剂和电子材料。

    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof
    25.
    发明授权
    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof 失效
    光学活性3-烷基羧酸的制备方法及其中间产物

    公开(公告)号：US07534908B2

    公开(公告)日：2009-05-19

    申请号：US11569452

    申请日：2005-05-12

    申请人： Klas Sorger ,  Jürgen Stohrer

    发明人： Klas Sorger ,  Jürgen Stohrer

    IPC分类号： C07C51/38 ,  C07C53/126 ,  C07C55/02 ,  C07B53/00

    CPC分类号： C07C51/09 ,  C07B2200/07 ,  C07C51/38 ,  C07C67/343 ,  C07C55/02 ,  C07C53/126 ,  C07C69/34

    摘要： An enantioselective method for producing optically active 3-alkyl carboxylic acids comprises transforming an optically active secondary alcohol into an optically active, activated compound by introducing a leaving group; reacting the activated compound with a malonic acid derivative to obtain an optically active, alkylated malonic acid compound, the reaction taking place exclusively in ether and/or carboxylic acid ester solvents and one or more aprotic polar solvents or alcohols as a cosolvent in a maximum proportion of 30 volume percent of total solvent, wherein the added cosolvent is not hexamethyl phosphoric acid triamide; the malonic acid compound is hydrolyzed if necessary to obtain the corresponding acid; and the corresponding acid is decarboxylated.

    摘要翻译： 用于制备光学活性3-烷基羧酸的对映选择性方法包括通过引入离去基团将光学活性仲醇转化为光学活性化合物; 使活化的化合物与丙二酸衍生物反应，得到光学活性的烷基化丙二酸化合物，该反应仅在醚和/或羧酸酯溶剂和一种或多种非质子极性溶剂或醇中作为共溶剂以最大比例进行 的总溶剂的30体积％，其中所添加的共溶剂不是六甲基磷酸三酰胺; 如果需要，丙二酸化合物被水解得到相应的酸; 并将相应的酸脱羧。

    Process of separating catalyst from oxidation mixtures
    26.
    发明授权
    Process of separating catalyst from oxidation mixtures 失效
    从氧化混合物中分离催化剂的方法

    公开(公告)号：US6129875A

    公开(公告)日：2000-10-10

    申请号：US245156

    申请日：1999-02-04

    申请人： Mark W. Dassel ,  Ader M. Rostami ,  Douglas J. Dudgeon ,  David C. DeCoster ,  Eustathios Vassiliou

    发明人： Mark W. Dassel ,  Ader M. Rostami ,  Douglas J. Dudgeon ,  David C. DeCoster ,  Eustathios Vassiliou

    IPC分类号： C07C51/43 ,  C07C51/16 ,  C07C51/31 ,  C07C55/02 ,  C07C55/14 ,  D01D1/02 ,  D01D5/08 ,  D01F13/00

    CPC分类号： C07C51/313

    摘要： This invention relates to methods for controlling the oxidation of hydrocarbons to dibasic acids, in the presence of a catalyst and a monobasic acid, by removing the catalyst from the reaction mixture, outside the oxidation zone, after the oxidation has taken place at least partially. Initially, the catalyst is partially precipitated and removed by reducing the water level in the reaction mixture and/or subjecting the reaction mixture to a temperature, at which or over which catalyst precipitates. After the initial partial precipitation of the catalyst, the remaining catalyst is subjected to a thermal treatment, during which at least part of the monobasic acid is removed leaving behind molten dibasic acids, in which, at least a major part of the remaining catalyst is precipitated, and it is removed. A minor part of remaining catalyst is removed by methods, which include but are not limited to ion exchange, precipitation with a base or appropriate salt, and electrodialysis. The precipitated catalyst in the three removal stages may be recycled in miscellaneous ways. The dibasic acid(s) may be removed at least partially before or after any catalyst precipitation stage.

    摘要翻译： 本发明涉及在催化剂和一元酸的存在下，通过在至少部分氧化发生氧化区之后从反应混合物外部除去催化剂来控制烃类二元酸的氧化的方法。 最初，通过降低反应混合物中的水位和/或使反应混合物达到催化剂沉淀的温度，部分沉淀和除去催化剂。 在催化剂的初始部分沉淀之后，对剩余的催化剂进行热处理，其中除去至少部分一元酸，留下熔融二元酸，其中至少大部分剩余的催化剂沉淀 ，并被删除。 通过方法除去剩余催化剂的一小部分，其包括但不限于离子交换，用碱或适当的盐沉淀和电渗析。 三个去除阶段中的沉淀催化剂可以以各种方式回收。 在任何催化剂沉淀阶段之前或之后，可以至少部分去除二元酸。