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11 条记录 (耗时 0.016 秒)

    Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives
    2.
    发明授权
    Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives 失效
    对映体纯脲1,3-二氧戊环-4-酮和1,3-氧硫杂环戊烷-5-酮衍生物的酶制备方法

    公开(公告)号：US06887700B2

    公开(公告)日：2005-05-03

    申请号：US10059774

    申请日：2002-01-30

    申请人： Alfred Popp ,  Jürgen Stohrer ,  Hermann Petersen ,  Andrea Gilch ,  Jodoca Rockinger-Mechlem

    发明人： Alfred Popp ,  Jürgen Stohrer ,  Hermann Petersen ,  Andrea Gilch ,  Jodoca Rockinger-Mechlem

    IPC分类号： B01D3/00 ,  B01D11/04 ,  C12P41/00 ,  C12P17/16

    CPC分类号： C12P41/001

    摘要： A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.

    摘要翻译： 提供了一种制备对映纯化的1,3-二氧戊环-4-酮或1,3-氧硫杂环戊烷-5-酮衍生物的方法，其包括使含有对映异构体1,3-二氧戊环-4-酮或1,3- 氧硫杂环戊烷-5-酮衍生物和具有水解活性的酶在亲核试剂存在下接触。 一种对映异构体的二氧杂环戊酮/氧硫杂环戊酮环的切割通过具有水解活性的酶发生，并且在发生一种对映异构体的切割之后，将1,3-二氧戊环-4-酮或1,3-氧硫杂环戊烷-5 一个衍生物是孤立的。

    Process for the precipitation of cystine
    3.
    发明授权
    Process for the precipitation of cystine 有权

    公开(公告)号：US06548700B2

    公开(公告)日：2003-04-15

    申请号：US09905359

    申请日：2001-07-13

    申请人： Wolfgang Döring ,  Jürgen Stohrer

    发明人： Wolfgang Döring ,  Jürgen Stohrer

    IPC分类号： C07C32300

    CPC分类号： C07C319/28 ,  C07C323/58

    摘要： A process for precipitating cystine from a solution in sulfuric acid, includes forming a mixture of a solution of cystine in aqueous sulfuric acid and of an aqueous solution of a base by simultaneous metering the cystine solution and the aqueous base solution into a mixing container. The metering takes place in such a way that the mixture in the container has a pH between 1.0 and 7.0 and a temperature between 30° C. and the boiling point of the mixture.

    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof
    4.
    发明授权
    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof 失效
    光学活性3-烷基羧酸的制备方法及其中间产物

    公开(公告)号：US07534908B2

    公开(公告)日：2009-05-19

    申请号：US11569452

    申请日：2005-05-12

    申请人： Klas Sorger ,  Jürgen Stohrer

    发明人： Klas Sorger ,  Jürgen Stohrer

    IPC分类号： C07C51/38 ,  C07C53/126 ,  C07C55/02 ,  C07B53/00

    CPC分类号： C07C51/09 ,  C07B2200/07 ,  C07C51/38 ,  C07C67/343 ,  C07C55/02 ,  C07C53/126 ,  C07C69/34

    摘要： An enantioselective method for producing optically active 3-alkyl carboxylic acids comprises transforming an optically active secondary alcohol into an optically active, activated compound by introducing a leaving group; reacting the activated compound with a malonic acid derivative to obtain an optically active, alkylated malonic acid compound, the reaction taking place exclusively in ether and/or carboxylic acid ester solvents and one or more aprotic polar solvents or alcohols as a cosolvent in a maximum proportion of 30 volume percent of total solvent, wherein the added cosolvent is not hexamethyl phosphoric acid triamide; the malonic acid compound is hydrolyzed if necessary to obtain the corresponding acid; and the corresponding acid is decarboxylated.

    摘要翻译： 用于制备光学活性3-烷基羧酸的对映选择性方法包括通过引入离去基团将光学活性仲醇转化为光学活性化合物; 使活化的化合物与丙二酸衍生物反应，得到光学活性的烷基化丙二酸化合物，该反应仅在醚和/或羧酸酯溶剂和一种或多种非质子极性溶剂或醇中作为共溶剂以最大比例进行 的总溶剂的30体积％，其中所添加的共溶剂不是六甲基磷酸三酰胺; 如果需要，丙二酸化合物被水解得到相应的酸; 并将相应的酸脱羧。

    Preparation of organozinc halides from reactive halogen compounds and their use
    8.
    发明授权
    Preparation of organozinc halides from reactive halogen compounds and their use 失效
    从活性卤素化合物制备有机锌卤化物及其用途

    公开(公告)号：US06603034B2

    公开(公告)日：2003-08-05

    申请号：US10308397

    申请日：2002-12-03

    申请人： Klas Sorger ,  Hermann Petersen ,  Jürgen Stohrer

    发明人： Klas Sorger ,  Hermann Petersen ,  Jürgen Stohrer

    IPC分类号： C07F306

    CPC分类号： C07F3/06

    摘要： A process for preparing organozinc halides in solvents, includes reacting a reactive halogen compound with zinc in one or more carboxylic esters. It is also possible to prepare keto, hydroxyl and amino compounds of organozinc halides obtained in a first step from a reactive halogen compound and zinc in one or more carboxylic esters, wherein the organozinc halide obtained is reacted in a second step with an electrophilic reaction partner and the reaction product of the second step is hydrolyzed in a third step.

    摘要翻译： 在溶剂中制备有机卤化锌的方法包括使反应性卤素化合物与锌在一种或多种羧酸酯中反应。 还可以制备在第一步中获得的有机锌卤化物的酮基，羟基和氨基化合物，其中反应性卤素化合物和锌在一种或多种羧酸酯中，其中获得的有机卤化锌在第二步中与亲电子反应配对物 并且在第三步骤中将第二步的反应产物水解。