公开(公告)号：US11992837B2

公开(公告)日：2024-05-28

申请号：US18165434

申请日：2023-02-07

Applicant: International Business Machines Corporation

Inventor： Evan Colgan ,  Joshua T. Smith ,  Benjamin Wunsch

IPC: B81C1/00 ,  B01L3/00 ,  B81B7/00 ,  G01N15/02

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B81B7/0061 ,  B81C1/00111 ,  B81C1/00309 ,  G01N15/0255 ,  B01L3/502723 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2300/12 ,  B81B2201/058 ,  B81B2203/0361 ,  G01N2015/0288

Abstract: A method for fabricating a fluidic device includes depositing a sacrificial material on a pillar array arranged on a substrate. The method also includes removing a portion of the sacrificial material. The method further includes depositing a sealing layer on the pillar array to form a sealed fluidic cavity.

公开(公告)号：US20240165623A1

公开(公告)日：2024-05-23

申请号：US18281514

申请日：2022-03-11

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Ali Sultan ,  Sini Skariah ,  Arum Han ,  Adrian Guzman

IPC: B01L3/00 ,  G01N15/01 ,  G01N15/10

CPC classification number: B01L3/502784 ,  B01L3/502707 ,  G01N15/01 ,  G01N15/10 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/12 ,  G01N2015/1028

Abstract: A method and an integrated device are provided for high-throughput screening of cellular libraries utilizing a droplet microfluidic-based approach. The integrated device comprises 8 or more major functionalities including droplet generation, droplet incubation, droplet reflow, droplet cleaving/generation, droplet synchronization, droplet merging, droplet detection, and droplet sorting for complex screening assays. Integration of each of the droplet functionalities onto a single chip reduces drastic changes in flow experienced at various chip-to-chip interfaces, and the possibility of error.

公开(公告)号：US11986824B2

公开(公告)日：2024-05-21

申请号：US17401627

申请日：2021-08-13

Applicant: CytoVale Inc.

Inventor： Henry Tat Kwong Tse ,  Ajay M. Shah ,  Lionel Guillou ,  Roya Sheybani ,  Christopher Dahlberg ,  Anne E. Jensen

IPC: B01L3/00 ,  G06N3/02 ,  G06T7/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  G06N3/02 ,  G06T7/0012 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0694 ,  B01L2200/12 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0436 ,  G06T2207/30024 ,  G06T2207/30104

Abstract: A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.

公开(公告)号：US20240139741A1

公开(公告)日：2024-05-02

申请号：US18384649

申请日：2023-10-27

Applicant: CYTONOME/ST, LLC

Inventor： Johnathan Charles Sharpe ,  Pascal Spink ,  Peter Kiesel

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2400/08

Abstract: A massively parallel microfluidic chip is provided having a plurality of sections that are stacked or layered along a stacking direction to form a plurality of microchannels at least partially oriented to flow along the stacking direction. The plurality of sections can include a transfer section for introduction of sample fluid including particles, a particle focusing section configured to focus the particles in the sample fluid, and an actuation section including a plurality of interrogation regions and a plurality of actuators. Each interrogation region and actuator is associated with at least one microchannel in the plurality of microchannels. The arrangement of the microfluidic channels along the stacking direction enables an extremely high packing density of channels and interrogation regions on a single chip to provide massively parallel processing of particles.

公开(公告)号：US11944972B2

公开(公告)日：2024-04-02

申请号：US17335510

申请日：2021-06-01

Applicant: The General Hospital Corporation

Inventor： Ravi Kapur ,  Kyle C. Smith ,  Mehmet Toner

IPC: B01L3/00 ,  A61K35/28 ,  G01N1/40 ,  G01N15/00 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14

CPC classification number: B01L3/502761 ,  A61K35/28 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  G01N1/4077 ,  G01N15/0255 ,  G01N15/0618 ,  G01N15/1484 ,  B01L3/502776 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0877 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N2001/4088 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0288 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2015/1493

Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

公开(公告)号：US20240091774A1

公开(公告)日：2024-03-21

申请号：US17945682

申请日：2022-09-15

Applicant: HALCYON BIOMEDICAL, INCORPORATED

Inventor： Sean Christopher Gifford

IPC: B01L3/00

CPC classification number: B01L3/502776 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/087

Abstract: An example system includes a passive dampener device having a chamber to hold a fluid. The passive dampener device is fluidically coupleable to a pump and a microfluidic device. The chamber has an air headspace to dampen pressure waves created by the pump in a sample fluid flow through the microfluidic device.

公开(公告)号：US11919000B2

公开(公告)日：2024-03-05

申请号：US17067534

申请日：2020-10-09

Applicant: 1859, Inc.

Inventor： Devon Cayer ,  Andrew MacConnell ,  Pavel Chubukov ,  Ramesh Ramji ,  Sean Stromberg

IPC: B01L3/00 ,  C12N15/10 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6876 ,  C40B20/04 ,  C40B30/08 ,  C40B50/06 ,  C40B50/16

CPC classification number: B01L3/502761 ,  C12N15/1093 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6876 ,  C40B50/06 ,  C40B50/16 ,  B01L2200/0652 ,  B01L2400/0403 ,  C40B20/04 ,  C40B30/08

Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.

公开(公告)号：US11918998B2

公开(公告)日：2024-03-05

申请号：US17682394

申请日：2022-02-28

Applicant: bioMerieux, Inc. ,  BioFire Defense, LLC

Inventor： John D. Walsh ,  Christopher S. Ronsick ,  Mark S. Wilson ,  Kirk Ririe ,  Ryan T. Hill

IPC: B01L3/00 ,  B01L3/02 ,  B04B5/04 ,  C12M1/00 ,  C12Q1/24 ,  G01N1/20 ,  G01N1/40 ,  B04B11/04

CPC classification number: B01L3/50215 ,  B01L3/0296 ,  B01L3/5021 ,  B01L3/5082 ,  B01L3/50825 ,  B04B5/0414 ,  C12M45/05 ,  C12Q1/24 ,  G01N1/2035 ,  G01N1/4077 ,  B01L2200/02 ,  B01L2200/0652 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/0848 ,  B01L2300/123 ,  B01L2400/0409 ,  B01L2400/0478 ,  B01L2400/0633 ,  B01L2400/0683 ,  B04B2005/0435 ,  B04B2011/046 ,  G01N2001/4083

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

公开(公告)号：US11904317B2

公开(公告)日：2024-02-20

申请号：US17047545

申请日：2019-04-18

Applicant: HIFIBIO SAS

Inventor： Annabelle Patricia Veronique Gérard ,  Vera Menrath

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/569

CPC classification number: B01L3/502784 ,  G01N33/54366 ,  G01N33/569 ,  B01L2200/0652 ,  B01L2200/16 ,  B01L2400/02 ,  G01N2458/00

Abstract: A first aspect of the present invention is directed to a method for the detection of a compound of interest in a microfluidic system. A second aspect of the present invention relates to the use of the method according to the first aspect for monitoring a biological event. A further aspect of the present invention is directed to a microfluidic system and the use thereof for carrying out the method according to the first aspect.

公开(公告)号：US20240052284A1

公开(公告)日：2024-02-15

申请号：US17766339

申请日：2020-10-16

Applicant: AENITIS TECHNOLOGIES

Inventor： Jérémie GACHELIN ,  Emmanuel VINCENT

IPC: C12M1/42 ,  C12M1/00 ,  B01L3/00 ,  C12M1/34

CPC classification number: C12M35/04 ,  C12M47/04 ,  B01L3/502761 ,  C12M41/36 ,  B01L2300/0663 ,  B01L2400/0436 ,  B01L2300/18 ,  B01L2400/0439 ,  B01L2200/0652 ,  B01L2300/0864

Abstract: A device for separating and/or isolating and/or washing target particles from a particles suspension. The device includes at least two inlets, at least two outlets, a container having a longitudinal axis and a chamber for fluid flow, being configured to be associated with a transducer, at least one transducer configured to generate bulk acoustic waves within the chamber, and at least one flow rate sensor configured to measure the flow rate of the fluid in the chamber. The inlets are located on one end of the container and the outlets are located on the other end along the longitudinal axis. The first and second inlet are each located on either side of the longitudinal axis, the first inlet and the second outlet are each located on either side of the longitudinal axis, and the second inlet and the first outlet are each located on either side of the longitudinal axis.