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    TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE
    3.
    发明公开
    TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE 审中-公开

    公开(公告)号：US20240279589A1

    公开(公告)日：2024-08-22

    申请号：US18391490

    申请日：2023-12-20

    申请人： GID Bio, Inc.

    发明人： William W. Cimino ,  Ramon Llull ,  Adam J. Katz

    IPC分类号： C12M1/00 ,  A61K35/32 ,  A61L27/00 ,  A61M1/00 ,  C12M1/33 ,  C12N5/077

    CPC分类号： C12M47/04 ,  A61K35/32 ,  A61L27/00 ,  C12M45/02 ,  C12M45/05 ,  C12N5/0653 ,  A61M1/892 ,  A61M2202/08

    摘要： A portable apparatus useful for collection and processing of human biological material, such as adipose or cancellous bone material, to prepare a concentrated product (e.g., stromal vascular fraction). The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a pellet well for collecting concentrate product in the form of a pellet phase from centrifuge processing. The pellet well is accessible only from above when the apparatus is in an access orientation. Collected pellet phase material may be removed from the pellet well by direct aspiration, without suspending the material in a suspension liquid within the container. Access ports may be configured for access only from above the container. The apparatus may include a tissue collector disposed in the disuse retention volume to engage and collect collagen or other stringy tissue. A method of processing adipose tissue to concentrate leuko stromal vascular cells includes multi-step processing using a portable container.

    CELL SEPARATION APPARATUS AND METHODS OF USE
    6.
    发明申请
    CELL SEPARATION APPARATUS AND METHODS OF USE 有权
    细胞分离装置及其使用方法

    公开(公告)号：US20160237396A1

    公开(公告)日：2016-08-18

    申请号：US14868235

    申请日：2015-09-28

    申请人： TISSUE GENESIS, LLC

    发明人： Gregory D. Ariff ,  Thomas Cannon ,  Jennifer L. Case ,  Christian L. Haller ,  Paul Kosnik ,  Charles P. Luddy ,  Craig A. Mauch ,  Erik Vossman ,  Stuart K. Williams

    IPC分类号： C12M1/00

    CPC分类号： C12M47/04 ,  A61K35/12 ,  C12M45/05 ,  C12M45/06 ,  C12M45/09

    摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

    摘要翻译： 本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。 本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。 细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。 自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。 本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。

    Systems and methods for processing cells
    7.
    发明授权
    Systems and methods for processing cells 有权
    处理细胞的系统和方法

    公开(公告)号：US08893995B2

    公开(公告)日：2014-11-25

    申请号：US13933034

    申请日：2013-07-01

    申请人： Auxocell Laboratories, Inc.

    发明人： Rouzbeh R. Taghizadeh ,  John Meade

    IPC分类号： B02C9/04 ,  C12M1/33 ,  C12N5/073 ,  C12M1/00

    CPC分类号： C12N5/0605 ,  A01N1/0242 ,  B02C18/10 ,  B02C18/30 ,  C12M45/02 ,  C12M45/05 ,  C12M45/09 ,  C12M45/22 ,  C12N2509/00 ,  C12N2509/10

    摘要： The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user.

    摘要翻译： 本发明有效地并且经济地从组织中提取和收集细胞。 本发明人已经发现组织可以被有效地破碎，并且所得到的细胞可以使用具有多种成分的系统或试剂盒进行纯化。 本发明的优点在于，组织处理发生在封闭系统中，即使在加工过程中例如通过使用阀门，夹具和热封等部件被去除时，整个过程也可以保持无菌性。 此外，根据应用或用户的具体需要，可以自动或手动完成任何或全部步骤。

    Processes and Systems for Alcohol Production and Recovery
    8.
    发明申请
    Processes and Systems for Alcohol Production and Recovery 有权
    酒精生产和回收过程和系统

    公开(公告)号：US20130309738A1

    公开(公告)日：2013-11-21

    申请号：US13887209

    申请日：2013-05-03

    申请人： BUTAMAX ADVANCED BIOFUELS LLC

    发明人： Steven Christopher BARR ,  Robert W. Sylvester ,  Joseph J. Zaher

    IPC分类号： C12P7/16

    CPC分类号： C12P7/06 ,  C12M21/12 ,  C12M29/18 ,  C12M45/04 ,  C12M45/05 ,  C12P7/16 ,  Y02E50/17 ,  Y10T29/49716

    摘要： The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present invention also relates to processes for recovering butanol produced in a fermentative process in a butanol production plant that may be converted to ethanol production plant.

    摘要翻译： 本发明涉及使用例如可逆地改性丁醇生产的乙醇生产装置，即发酵过程中生产的丁醇，即乙醇生产装置可以转化为丁醇生产，但也可以 回到乙醇生产。 本发明还涉及在可以转化为乙醇生产设备的丁醇生产设备中的发酵过程中回收生产的丁醇的方法。

    Tissue dissociating system and method
    9.
    发明授权
    Tissue dissociating system and method 失效
    组织解离系统及方法

    公开(公告)号：US5786207A

    公开(公告)日：1998-07-28

    申请号：US864444

    申请日：1997-05-28

    申请人： Adam J. Katz ,  Ramon Llull

    发明人： Adam J. Katz ,  Ramon Llull

    IPC分类号： C12M3/08 ,  C07G17/00

    CPC分类号： C12M45/02 ,  C12M45/05 ,  C12M47/04

    摘要： A tissue dissociation method and system for washing and dissociating tissue and producing a cellular suspension for use in autologous, cell-based therapies or research wherein a sterile environment is maintained. More particularly, a system for dissociating tissue comprising a housing unit, a first compartment having a plurality of pores providing for fluid communication between the interior of the first compartment and the interior of the housing unit, a first inlet port that provides communication between the exterior environment and the interior of the first compartment and thereby provides a means for introducing solutions into the interior of the first compartment, a second compartment, a second inlet port for introducing a tissue sample into the system, a means for agitating or rotating the second compartment in the housing unit, a means for controlling the exit of effluent from the housing unit, a first receptacle, and a centrifuge-ready second receptacle for collecting a resulting cell suspension. The method comprises introducing a tissue sample into the system and subjecting it to a washing phase and a dissociating phase wherein the tissue is agitated or rotated. The tissue may also be subjected to a sedentary phase and a phase in which a solution is added to the resulting cell suspension to cease tissue dissociation. At the conclusion of the tissue dissociation process, the resulting cell suspension is collected in a centrifuge-ready receptacle.

    摘要翻译： 用于洗涤和解离组织并产生用于自体，基于细胞的疗法或研究中的细胞悬浮液的组织解离方法和系统，其中维持无菌环境。 更具体地，涉及用于解离组织的系统，包括壳体单元，具有提供用于在第一隔室的内部和壳体单元的内部之间流体连通的多个孔的第一隔室，提供外部之间的连通的第一入口端口 环境和第一隔室的内部，从而提供用于将溶液引入第一隔室的内部的装置，第二隔室，用于将组织样品引入系统的第二入口端口，用于搅动或旋转第二隔室 在壳体单元中，用于控制来自壳体单元的流出物的排出的装置，第一容器和用于收集所得到的细胞悬浮液的离心机就绪的第二容器。 该方法包括将组织样品引入系统并使其经历洗涤阶段和解离阶段，其中组织被搅动或旋转。 组织也可以经受静止期和将所述溶液加入到所得细胞悬浮液中以停止组织解离的阶段。 在组织解离过程结束时，将得到的细胞悬浮液收集在离心机容器中。