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公开(公告)号：US11813614B2
公开(公告)日：2023-11-14
申请号：US17547102
申请日：2021-12-09
发明人： Brian Schryver
CPC分类号： B01L7/50 , B01L7/04 , C12M45/22 , F25D3/125 , B01L2200/025 , B01L2200/143 , B01L2300/025 , B01L2300/0854 , B01L2300/1894
摘要： Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below −50° C.
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公开(公告)号：US11703275B2
公开(公告)日：2023-07-18
申请号：US16689175
申请日：2019-11-20
申请人： Asymptote Ltd.
CPC分类号： F25D29/001 , A01N1/0257 , A01N1/0273 , A01N1/0284 , B01L7/02 , B01L7/50 , F25D29/008 , G06F9/451 , G06F16/2379 , H04L67/125 , B01L2200/18 , B01L2300/023 , B01L2300/0663 , F25D2600/06
摘要： A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
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公开(公告)号：US20180231473A1
公开(公告)日：2018-08-16
申请号：US15949922
申请日：2018-04-10
发明人： Shane Elen , Matt Hall , Wuyi Wang
CPC分类号： G01N21/87 , B01L7/50 , B01L2300/1894
摘要： A cooling apparatus includes a container configured to contain a coolant within a space. The apparatus further includes a cooling block positioned substantially within the space and having a high heat capacity such that the space not occupied by the cooling block is filled with a coolant to a level at or below the top of the cooling block, and a placement structure having high thermal conductivity positioned on top of the cooling block and outside of the space. A method for cooling an object is also provided, which includes inserting a coolant into a container configured to contain the coolant within a space, and placing the object on a placement structure outside the space. For this method, the placement structure has a high thermal conductivity and is coupled to a cooling block, the cooling block having a high heat capacity and positioned substantially within the space.
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公开(公告)号：US09983143B2
公开(公告)日：2018-05-29
申请号：US12380416
申请日：2009-02-27
申请人： Shane Elen , Matt Hall , Wuyi Wang
发明人： Shane Elen , Matt Hall , Wuyi Wang
CPC分类号： G01N21/87 , B01L7/50 , B01L2300/1894
摘要： A cooling apparatus includes a container configured to contain a coolant within a space. The apparatus further includes a cooling block positioned substantially within the space and having a high heat capacity such that the space not occupied by the cooling block is filled with a coolant to a level at or below the top of the cooling block, and a placement structure having high thermal conductivity positioned on top of the cooling block and outside of the space. A method for cooling an object is also provided, which includes inserting a coolant into a container configured to contain the coolant within a space, and placing the object on a placement structure outside the space. For this method, the placement structure has a high thermal conductivity and is coupled to a cooling block, the cooling block having a high heat capacity and positioned substantially within the space.
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公开(公告)号：US09664431B2
公开(公告)日：2017-05-30
申请号：US13794569
申请日：2013-03-11
申请人： The World Egg Bank
发明人： Steven F. Mullen , Daniel Ling , Justin Carland
IPC分类号： F25D3/08 , F25D25/00 , F25B19/00 , F25D17/02 , F25D11/00 , B01L9/06 , A01N1/02 , B01L7/04 , G01N1/42 , B01L7/00
CPC分类号： F25D11/003 , A01N1/0268 , B01L7/04 , B01L7/50 , B01L9/06 , B01L9/065 , B01L2200/18 , B01L2300/021 , B01L2300/042 , B01L2300/0609 , B01L2300/069 , B01L2300/0838 , B01L2300/185 , B01L2300/1883 , B01L2300/1894 , G01N1/42
摘要： The present disclosure describes a cryogenic vessel or holder designed to retain biological specimens, such as embryos or unfertilized eggs. The holder is insulated to reduce the rate of warming of the biological specimens, can hold numerous biological specimens snuggly to alleviate damage by jarring, and has an inner cavity that receives cryogen to keep the biological specimens immersed in cryogen during shipping. The design allows for safer shipping and handling of the biological specimens with less risk of damage. The design can also be utilized as a long-term sample holding and storage device.
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公开(公告)号：US20160097576A1
公开(公告)日：2016-04-07
申请号：US14877887
申请日：2015-10-07
申请人： Wojciech Bartkowski
发明人： Wojciech Bartkowski
IPC分类号： F25C1/04
CPC分类号： F25C1/22 , B01L3/5021 , B01L7/50 , B01L9/06 , B01L2200/082 , B01L2300/0829 , B01L2300/123
摘要： The present invention relates to an elastic mold for holding and freezing a liquid. The mold is constructed of unitary construction and comprises of one or more walls and a base, wherein said one or more walls form a compartment. A plurality of protrusions extend upwards from said base. The liquid held in said elastic is frozen into the shape of a test tube rack.
摘要翻译： 本发明涉及一种用于保持和冷冻液体的弹性模具。 模具由单一结构构成并且包括一个或多个壁和底座，其中所述一个或多个壁形成隔室。 多个突起从所述底座向上延伸。 保持在弹性体中的液体被冻结成试管架的形状。
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7.发明授权公开(公告)号：US09297499B2
公开(公告)日：2016-03-29
申请号：US14097357
申请日：2013-12-05
CPC分类号： F17C13/001 , A01N1/0257 , A01N1/0268 , B01L7/50 , B01L9/06 , B01L2200/147 , B01L2300/1883 , F25D3/10
摘要： A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.
摘要翻译： 描述了用于冷冻介质中生物样品的冷冻保存和/或玻璃化的装置。 该装置优选地包括用于接收含有液相氮中的生物样品的容器的浴。 在一个示例中，浴包括从底壁部分大致垂直延伸的第一构件，该底壁部分将浴室的内部腔分成适于接收一定体积的低温冷冻介质的第一子室，以及适于 以从第一子室接收冷冻介质。 第二构件在浴的侧壁部分之间大致水平地延伸，并且包括用于接收含生物样品的容器的至少一个开口。 还描述了包括低温存储装置和容器的试剂盒。
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公开(公告)号：US20150231635A1
公开(公告)日：2015-08-20
申请号：US14640471
申请日：2015-03-06
发明人： Kazunori Okano , Kenji Yasuda
CPC分类号： B01L7/50 , A01N1/0284 , G01N33/5061 , G01N33/566
摘要： In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction of each cell is retained. In the labeling, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. Immediately after the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell separation chip.
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公开(公告)号：US09040001B2
公开(公告)日：2015-05-26
申请号：US13856409
申请日：2013-04-03
申请人： Lloyd Wright
发明人： Lloyd Wright
CPC分类号： B01L7/50 , B01L9/523 , B01L2300/0829 , B01L2300/185 , G01N35/028 , G01N2035/00396
摘要： The present invention provides methods and apparatus for efficiently providing accurate temperature control of a microtiter cold plate and precise alignment of the microtiter cold plate with a microtiter plate.
摘要翻译： 本发明提供了有效提供微量滴定板的精确温度控制和微量滴定板与微量滴定板精确对准的方法和装置。
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公开(公告)号：US09010202B2
公开(公告)日：2015-04-21
申请号：US13560647
申请日：2012-07-27
申请人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
发明人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
CPC分类号： G01N23/20033 , B01L7/50 , G01N2223/612 , H01J37/20 , H01J37/26 , H01J2237/0216 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and amount of liquid nitrogen present in the vessel. The Dewar neck design reduces entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar and other environmental effects.
摘要翻译： 用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。 可伸缩的样品架头在运输过程中保护样品。 优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高的倾斜角和液氮量。 杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。 样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。 冷却和样品转移机制降低了热漂移和由杜瓦瓶中存在的液氮蒸发和其他环境影响产生的振动的不利影响。
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