公开(公告)号：US20240310394A1

公开(公告)日：2024-09-19

申请号：US18604524

申请日：2024-03-14

申请人： Sartorius Biohit Liquid Handling Oy

发明人： Hannes Jantunen ,  Emilia Varhimo

IPC分类号： G01N35/00 ,  B01L3/02

CPC分类号： G01N35/00623 ,  B01L3/0237 ,  B01L2200/143 ,  B01L2300/025

摘要： According to an example aspect of the present invention, there is provided a method comprising: quantifying a total experimental error of a multi-step sample handling and/or analysis sequence comprising at least two steps, including quantifying respective individual experimental errors of said at least two steps; and presenting said total experimental error and/or an output value derived from said total experimental error by an output device.

公开(公告)号：US11845078B2

公开(公告)日：2023-12-19

申请号：US15492931

申请日：2017-04-20

申请人： Cue Health Inc.

发明人： Ayub Khattak ,  Clinton Sever

IPC分类号： B01L3/00 ,  G01N1/02 ,  G01N35/10 ,  H04M1/72409 ,  G01N35/08 ,  G01N33/543 ,  G01N27/327 ,  G01N35/00 ,  G01N27/28 ,  B05D3/00 ,  F16K99/00 ,  C12Q1/6825 ,  G01N33/58 ,  G01N21/78 ,  H04M1/72412

CPC分类号： B01L3/502715 ,  B01L3/5027 ,  B01L3/5029 ,  B01L3/502723 ,  B01L3/502738 ,  B05D3/002 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  G01N1/02 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3273 ,  G01N33/5438 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  H04M1/72409 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D2518/00 ,  F16K2099/0084 ,  G01N21/78 ,  G01N27/3272 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72412 ,  Y10T137/1797

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20230338951A1

公开(公告)日：2023-10-26

申请号：US18214801

申请日：2023-06-27

申请人： Cue Health Inc.

发明人： Ayub Khattak ,  Clinton Sever

IPC分类号： B01L3/00 ,  G01N27/327 ,  G01N33/543 ,  G01N33/58 ,  G01N1/02 ,  F16K99/00 ,  H04M1/72409 ,  G01N35/08 ,  B05D3/00 ,  G01N35/00 ,  G01N35/10 ,  C12Q1/6825 ,  G01N27/28 ,  G01N21/78 ,  H04M1/72412

CPC分类号： B01L3/502715 ,  B01L3/5029 ,  G01N27/3271 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/581 ,  G01N1/02 ,  F16K99/0032 ,  G01N27/3273 ,  G01N33/54373 ,  B01L3/5027 ,  H04M1/72409 ,  G01N35/08 ,  G01N33/54306 ,  G01N33/5438 ,  B05D3/002 ,  F16K99/0036 ,  G01N35/0098 ,  G01N33/54366 ,  B01L3/502723 ,  B01L3/502738 ,  G01N35/00029 ,  G01N35/1095 ,  C12Q1/6825 ,  G01N27/28 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2400/0683 ,  B01L2300/0645 ,  B01L2200/027 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0677 ,  B01L2200/0668 ,  B01L2300/06 ,  B01L2300/12 ,  B05D2518/00 ,  G01N2035/00564 ,  B01L2200/028 ,  B01L2300/0627 ,  B01L2300/0816 ,  G01N2001/027 ,  B01L2300/0867 ,  B01L2300/0838 ,  B01L2200/04 ,  F16K2099/0084 ,  B01L2200/0684 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/04 ,  B01L2200/10 ,  B01L2300/1827 ,  G01N27/3272 ,  G01N2035/00277 ,  B01L2300/025 ,  B01L2400/0487 ,  G01N21/78 ,  G01N2001/028 ,  Y10T137/1797 ,  G01N2458/30 ,  B01L2200/087 ,  B01L2300/0681 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/087 ,  H04M1/72412 ,  B01L2300/0864

摘要： This system takes in raw cellular material collected using a provided swab, blood collection device, urine collection device, or other sample collection device and transforms that biological material into a digital result, identifying the presence, absence and/or quantity of nucleic acids, proteins, and/or other molecules of interest.

公开(公告)号：US20230295708A1

公开(公告)日：2023-09-21

申请号：US18185001

申请日：2023-03-16

申请人： University of Dayton Research Institute

发明人： Vamsy Chodavarapu ,  Tchamie Kadja

IPC分类号： C12Q1/686 ,  B01L3/00 ,  B01L7/00

CPC分类号： C12Q1/686 ,  B01L3/502715 ,  B01L7/52 ,  B01L2300/025 ,  B01L2300/1827 ,  B01L2300/0609 ,  B01L2300/0663

摘要： A real-time polymerase chain reaction (PCR) system includes a thermal cycler that controls a temperature of the system, a control system that controls the thermal cycler, an optical system and readout that displays results of a test of the sample for pathogens, and a network device that conveys the results of the test of the sample for pathogens. The thermal cycler comprises a denaturation controller that controls temperature of a denaturation phase, an annealing controller that controls temperature of an annealing phase, and an extension controller that controls temperature of an extension phase, where the three controllers are each individually selected by the control system.

公开(公告)号：US11686655B2

公开(公告)日：2023-06-27

申请号：US16812045

申请日：2020-03-06

申请人： Hall Labs, LLC

发明人： David R. Hall ,  David Crismon ,  Kevin Jeffrey Campbell

IPC分类号： A61B10/00 ,  E03D11/13 ,  G01N1/20 ,  B01L3/00 ,  G01N21/25 ,  G01N33/493 ,  G01N33/483 ,  G01N1/18 ,  A61B5/0205 ,  A61B5/00 ,  G01N1/38 ,  A61B5/021 ,  A61B5/145 ,  A61B5/20 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/318 ,  E03D9/08 ,  G01N33/48 ,  E03D11/00

CPC分类号： G01N1/2035 ,  A61B5/02055 ,  A61B5/6891 ,  A61B10/0038 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502738 ,  E03D11/13 ,  G01N1/18 ,  G01N1/38 ,  G01N21/255 ,  G01N33/4833 ,  G01N33/493 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/02444 ,  A61B5/14542 ,  A61B5/208 ,  A61B5/318 ,  A61B10/007 ,  A61B10/0012 ,  A61B2562/0247 ,  A61B2562/0257 ,  A61B2562/0271 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2400/0415 ,  B01L2400/0605 ,  E03D9/08 ,  E03D11/00 ,  G01N33/48 ,  G01N2001/205 ,  E03D11/12 ,  E03D11/13

摘要： An analytical toilet comprising a bowl adapted to receive excreta; one or more conduits for transporting a sample from the bowl; one or more fluid sources in fluid connection with the one or more conduits; and one or more microfluidic chips, comprising at least one fluid inlet; at least one fluid outlet; and a sensor configured to detect at least one property of an excreta sample is disclosed.

公开(公告)号：US20180264464A1

公开(公告)日：2018-09-20

申请号：US15989045

申请日：2018-05-24

申请人： Grace Bio-Labs, Inc.

发明人： Charles Greef ,  Joshua Snider ,  Steven Weaver ,  Jennipher Lyn Grudzien ,  Kelsey Anne Muller ,  Stephen E. Moody

IPC分类号： B01L3/00 ,  G01N33/487 ,  G01N21/64

CPC分类号： B01L3/5023 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/025 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/088 ,  B01L2300/12 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N21/6428 ,  G01N21/6452 ,  G01N33/4875 ,  G01N2021/0112 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/00108 ,  G01N2800/60

摘要： Methods and systems are provided making a porous nitrocellulose strip for use in a lateral flow test. The strip may be formed from a liquid polymer mixture dispensed onto the planar surface via a dispensing device positioned vertically above the planar surface. The strip may be printed with a microarray of binding ligands for use in the lateral flow test. Methods and systems are further provided for developing and viewing the results of the assay.

公开(公告)号：US10078093B2

公开(公告)日：2018-09-18

申请号：US15410669

申请日：2017-01-19

申请人： Hologic, Inc.

发明人： Jacob Flagle ,  Chia Yee Ang ,  Kenneth F. Defrietas ,  Ian Shaw ,  John Laviola ,  Samantha Perkins ,  Zachary R. Nicoson

IPC分类号： G01N35/04 ,  A61B6/00 ,  A61B10/02 ,  A61B10/00 ,  B01L3/00

CPC分类号： G01N35/04 ,  A61B6/4405 ,  A61B10/0096 ,  A61B10/0275 ,  A61B10/0283 ,  B01L3/502 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0684 ,  B01L2200/146 ,  B01L2200/18 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2400/0478 ,  B01L2400/049 ,  B01L2400/0605 ,  B01L2400/0644 ,  G01N2035/0481

摘要： A system for analysis of biopsy samples includes a tissue sample transport mechanism linking a biopsy sample excision tool to a tissue sample holder disposed in a staging area of an analysis unit. The tissue sample is automatically transported from the excision tool to the specimen holder, where the tissue sample is analyzed in the staging area of the analysis unit. The transport mechanism may include tubing and a vacuum source. The tissue sample holder may be configured to slow or temporarily stop a tissue sample for individual analysis, or collect multiple tissue samples for analysis as a group. A tissue sample sorting mechanism may be employed that allows separation of specimens that can be correlated to the analysis.

公开(公告)号：US09962703B2

公开(公告)日：2018-05-08

申请号：US15487956

申请日：2017-04-14

申请人： CUE INC.

发明人： Ayub Khattak ,  Clinton Sever ,  Paul Nelson ,  Ryan Cooper ,  Thomas Congdon ,  Justin Demartino ,  Raphael Shapiro ,  Mark Duncan

IPC分类号： G01N31/22 ,  B01L3/00 ,  B05D3/00 ,  C12Q1/68 ,  F16K99/00 ,  G01N27/28 ,  G01N27/327 ,  G01N33/543 ,  G01N33/58 ,  G01N35/00 ,  H04M1/725 ,  B01L7/00 ,  G01N1/02 ,  G01N21/78 ,  G01N35/10

CPC分类号： B01L3/508 ,  B01F11/0266 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00554 ,  G01N2458/30 ,  H04M1/72527 ,  Y10T137/1797

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20180064384A1

公开(公告)日：2018-03-08

申请号：US15699962

申请日：2017-09-08

申请人： HEMEX HEALTH, INC.

发明人： PETER GALEN ,  UMUT ATAKAN GURKAN ,  ARWA FRAIWAN ,  MUHAMMAD NOMAN HASAN ,  DANIEL E. GRUPP ,  JOSHUA KING HOYT ,  JAMES THORNE ,  BRIAN T. GRIMBERG

IPC分类号： A61B5/157 ,  G01N33/49 ,  G01N1/31 ,  B01L3/00 ,  G01N27/447 ,  A61B5/151 ,  A61B5/15 ,  A61B5/00

CPC分类号： A01H5/10 ,  A01H1/02 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/1519 ,  A61B5/15192 ,  A61B5/157 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0214 ,  B01L3/502 ,  B01L3/50273 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0421 ,  B01L2400/0481 ,  C12N15/8243 ,  C12N15/8245 ,  C12N15/8247 ,  C12N15/8251 ,  C12N15/8274 ,  C12N15/8279 ,  C12N15/8286 ,  C12N15/8289 ,  G01N1/312 ,  G01N27/44704 ,  G01N27/44717 ,  G01N27/44743 ,  G01N27/44756 ,  G01N33/49 ,  G01N2333/805

摘要： A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient.

公开(公告)号：US09751083B2

公开(公告)日：2017-09-05

申请号：US14680671

申请日：2015-04-07

申请人： University of Macau

发明人： Jie Gao ,  Tianlan Chen ,  Cheng Dong ,  Yanwei Jia ,  Pui-In Mak ,  Mang-I Vai ,  Rui Paulo da Silva Martins

IPC分类号： G01N27/27 ,  B01L3/00 ,  G01N27/447

CPC分类号： B01L3/502792 ,  B01L2200/143 ,  B01L2300/025 ,  B01L2300/0887 ,  B01L2400/0427 ,  G01N27/44704 ,  G01N27/44756 ,  G01N27/44791

摘要： According to one aspect of the present disclosure, a digital microfluidic system is provided. The digital microfluidic system includes a device, a control electronics, a field programmed gate array (FPGA), and a computer. The device includes a droplet on an electrode array, where the electrode array includes a plurality of electrodes. The control electronics connects to the device and provides an actuation pulse to the electrodes, where the control electronics generates a capacitance-derived frequency signal. The FPGA connects to the control electronics and collects the capacitance-derived frequency signal. The computer connects to the FPGA, the computer uses a frequency of the capacitance-derived frequency signal to calculate a precise droplet position and generates a duration voltage signal.