公开(公告)号：US09931604B2

公开(公告)日：2018-04-03

申请号：US14773796

申请日：2014-02-20

Applicant: Merck Patent GmbH

Inventor： Luc Felden ,  David Lehmann ,  Marisa Hohnadel ,  Sebastien Jouette

IPC: B01F11/00 ,  B01F11/02 ,  G01N1/28 ,  G01N35/00

CPC classification number: B01F11/02 ,  B01F11/0266 ,  B01F2215/0037 ,  G01N1/28 ,  G01N2035/00554

Abstract: An apparatus for performing sonication on liquid samples comprises a rack for holding an array of sample vials, an ultrasonic probe with an arrangement of recesses corresponding to the array of sample vials and adapted to respectively receive and contact an outer surface of a bottom portion of a respective one of the sample vials, and a counter-holder with an arrangement of pushing members corresponding to the array of sample vials and adapted to respectively apply a force to a respective one of the sample vials so as to push the bottom portion of each vial into contact with the associated recess of the probe. The apparatus can be used in a method of preparing a sample for detection of cell components (e.g. cell analyte, proteins, nucleid acids etc.) and applying sonication within certain parameter ranges which can provide a universal lysis method that can be applied to a large variety of cells or organisms like all bacteria, viruses, spores, yeast and mold within the same apparatus and process.

公开(公告)号：US09833102B2

公开(公告)日：2017-12-05

申请号：US13523961

申请日：2012-06-15

Applicant: Peter Peterson ,  Ross Peter Jones ,  Miles William Noel Hember ,  Javier Gonzalez-Zugasti

Inventor： Peter Peterson ,  Ross Peter Jones ,  Miles William Noel Hember ,  Javier Gonzalez-Zugasti

IPC: A47J31/44 ,  A47J31/00 ,  A47J31/36 ,  B65D85/804 ,  B01F11/00 ,  B01F11/02 ,  B01F13/00 ,  B01F13/08 ,  B01F15/00 ,  B01F3/12

CPC classification number: A47J31/002 ,  A47J31/3623 ,  A47J31/44 ,  B01F3/1242 ,  B01F11/0002 ,  B01F11/0005 ,  B01F11/0022 ,  B01F11/0042 ,  B01F11/0068 ,  B01F11/0258 ,  B01F11/0266 ,  B01F13/0052 ,  B01F13/0818 ,  B01F15/00318 ,  B01F15/00896 ,  B01F2215/0454 ,  B65D85/8043

Abstract: Apparatus and method for forming beverages using a beverage cartridge and sonic energy. A cartridge may include a sonic receiver, such as a feature that extends into an interior space of the cartridge and is arranged to receive a sonic emitter that introduces sonic energy into the interior space. The sonic receiver may be excited by sonic energy, which causes the sonic receiver to itself introduce sonic energy into the cartridge.

公开(公告)号：US09808778B2

公开(公告)日：2017-11-07

申请号：US13965964

申请日：2013-08-13

Applicant: Resodyn Corporation

Inventor： Lawrence C. Farrar ,  Scott L. Coguill ,  Peter A. Lucon ,  Janice Lucon

IPC: B01F11/02 ,  B01F11/00 ,  B01J19/10 ,  B01J8/34 ,  B01J8/40 ,  B01J19/00 ,  B01J4/00

CPC classification number: B01F11/0266 ,  B01F11/0077 ,  B01J4/002 ,  B01J8/34 ,  B01J8/40 ,  B01J19/006 ,  B01J19/10 ,  B01J2208/0015 ,  B01J2208/0061 ,  B01J2208/0084 ,  B01J2208/00867 ,  B01J2208/00902 ,  B01J2208/00938 ,  B01J2219/00085 ,  B01J2219/0077 ,  B01J2219/00772 ,  B01J2219/00777

Abstract: The present application is directed towards systems and methods for continuously reacting a combination of materials by use of an acoustic agitator and a continuous process vessel. The system can react, fluidize, mix, coat, dry, combine or segregate materials. The continuous processing system can include an acoustic agitator capable of being removably coupled to a continuous process vessel. The continuous process vessel can include a first inlet for introducing at least one process ingredient, a plurality of plates configured for directing a flow of the at least one process ingredient through the continuous process vessel and capable of transferring acoustic energy generated by the acoustic agitator into the at least one process ingredient, an outlet for discharging a product of the at least one process ingredient, and a fastener for removable coupling the continuous process vessel to the acoustic agitator.

公开(公告)号：US09791441B2

公开(公告)日：2017-10-17

申请号：US13919524

申请日：2013-06-17

Applicant: CLONDIAG GMBH

Inventor： Eugen Ermantraut ,  Ralf Bickel ,  Torsten Schulz ,  Thomas Ullrich ,  Jens Tuchscheerer

IPC: G01N21/00 ,  G01N33/569 ,  B01F11/00 ,  B01F11/02 ,  B01F13/00 ,  B01L3/00 ,  G01N21/03 ,  G01N35/00

CPC classification number: G01N33/56966 ,  B01F11/0045 ,  B01F11/0266 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0825 ,  B01L2400/0481 ,  G01N21/03 ,  G01N35/0099 ,  G01N2021/0346 ,  G01N2035/00346

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

公开(公告)号：US20170281530A1

公开(公告)日：2017-10-05

申请号：US15479674

申请日：2017-04-05

Applicant: THE COMPOUNDERS DEPOT, INC.

Inventor： Michael Bennett ,  Darian Chandler ,  John Neraas ,  Alton Samuel Kelley, II

IPC: A61K9/00 ,  B01F3/08 ,  A61K47/18 ,  A61K47/10 ,  A61K47/06

CPC classification number: B01F11/0002 ,  A61K9/1694 ,  B01F11/0028 ,  B01F11/0266 ,  B01F15/0224

Abstract: Embodiments of the present disclosure generally relate to systems and methods for mixing pharmaceutical compositions, agents and/or ingredients together. In one embodiment, a method can include a shell and a flexible pouch disposed within the shell. The flexible pouch can include at least one active pharmaceutical ingredient and at least one delivery agent. Further, the flexible pouch and the shell can be configured to receive a dispensing member for dispensing a predetermined amount of a pharmaceutical composition. Methods can also include subjecting the container to high intensity vibrations for a predetermined mixing time to produce the pharmaceutical composition.

公开(公告)号：US20170266630A1

公开(公告)日：2017-09-21

申请号：US14703991

申请日：2015-05-05

Applicant: David Arlen McDonald ,  Philip S. Petracca ,  William Scott Keeley

Inventor： David Arlen McDonald ,  Philip S. Petracca ,  William Scott Keeley

IPC: B01F3/04 ,  B67D1/12 ,  B67D1/04 ,  A23L2/54 ,  B67D1/08

CPC classification number: B01F3/04446 ,  A23L2/54 ,  A23V2002/00 ,  B01F3/04808 ,  B01F3/04978 ,  B01F11/0241 ,  B01F11/0266 ,  B67D1/04 ,  B67D1/0888 ,  B67D1/0894 ,  B67D1/1275 ,  B67D2001/0493

Abstract: The embodiment relates to beverage dispensing, and more particularly to the dispensing of a carbonated beverage, from any container into a vessel, providing a portion of the beverage as foam atop the dispensed beverage. To avoid the reduction of absorbed carbon dioxide in a carbonated beverage, increased atmospheric pressure is employed to move the beverage from the container through the apparatus and into the vessel. An oscillating means provides a sonic wave through the conduit and the liquid therein; the sonic wave initiates the reaction between the carbon dioxide and the ingredients in the beverage to cause the liquid to foam prior to dispensing into the vessel. Iterations include an adaptable apparatus for a beer tap and a means for passing the liquid to be dispensed through a permeable container filled with soluble material or a permeable container filled with a filtration means.

公开(公告)号：US09751057B2

公开(公告)日：2017-09-05

申请号：US15167712

申请日：2016-05-27

Applicant: The University Court of the University of Glasgow

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: B01F13/00 ,  B01F11/02 ,  B01J19/00 ,  B01L3/00 ,  C12N13/00 ,  G01N33/48

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A method of using a fluidics apparatus for lysing a cell. In the method, the cell is placed in a fluid sample contacting a substrate surface. The method further includes providing surface acoustic waves (SAWs) at the substrate surface, causing cell lyses.

公开(公告)号：US09718801B2

公开(公告)日：2017-08-01

申请号：US14404433

申请日：2013-07-01

Applicant: J P Love

Inventor： J P Love

IPC: A61K36/185 ,  C07D311/80 ,  B01D21/02 ,  B01D11/02 ,  B01F11/00 ,  B01F11/02

CPC classification number: C07D311/80 ,  A61K36/185 ,  A61K2236/00 ,  B01D11/0261 ,  B01D11/0288 ,  B01D21/02 ,  B01F11/0094 ,  B01F11/0266

Abstract: The present invention is directed to a method and device to isolate compounds from plant material using vibrational pulsing, vibrational decanting, vibrational sieving and vibrational rinsing. A susceptible liquid is generated by vibrational agitation, decanted when in a vibrating container and then collected by passing over a series of vibrating screens and then rinsed with water while collected on the vibrating screens and the residue collected. The isolated compound can either be collected in the decant or retained on the screens. In an embodiment of the invention, the vibrational rinsing step reduces unwanted impurities isolated.

公开(公告)号：US09375690B2

公开(公告)日：2016-06-28

申请号：US13391762

申请日：2010-08-24

Applicant: Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: G01N1/00 ,  B06B1/00 ,  B01F13/00 ,  B01F11/02 ,  B01J19/00 ,  B01L3/00

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behavior of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.

Abstract translation: 公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。 该设备具有一个具有用于定位流体样品的样品操作区的基底表面。 诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。 衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处表面声波的透射，分布和/或行为。 还公开了一种裂解细胞的方法。 在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

公开(公告)号：US20150239151A1

公开(公告)日：2015-08-27

申请号：US14628863

申请日：2015-02-23

Applicant: JTEKT CORPORATION

Inventor： Takafumi FUJII ,  Masaru Fuse ,  Takumi Mio

IPC: B29B7/38 ,  B29B7/60 ,  H01M4/04 ,  B29B7/46

CPC classification number: B29B7/38 ,  B01F3/1221 ,  B01F3/1271 ,  B01F3/20 ,  B01F7/00825 ,  B01F7/00833 ,  B01F7/081 ,  B01F11/0266 ,  B01F13/1027 ,  B01F15/00162 ,  B01F15/00253 ,  B01F15/0298 ,  B01F2003/1257 ,  B29B7/46 ,  B29B7/60 ,  H01M4/043

Abstract: A kneading device includes: a preliminary kneading device that produces a preslurry by agitating a powder and a liquid introduced and transferring them while wetting the powder with the liquid; and a main kneading device that causes the powder to be uniformly dispersed in the preslurry supplied from the preliminary kneading device to produce a slurry. The main kneading device includes a gap defined by two conical surfaces that face each other with a predetermined distance therebetween and rotate relative to each other about their central axes. The slurry is produced by passing the preslurry through the gap. With the preliminary kneading device, the powder is dispersed in the liquid after conforming to the liquid, which suppress damage to the powder. The conditions of main kneading can be changed only by adjusting the gap, which facilitates the operation of changing the conditions of the main kneading.

Abstract translation: 捏合装置包括：预混合装置，其通过搅拌粉末和引入的液体产生预浆液，同时用液体润湿粉末; 以及主要捏合装置，其使粉末均匀地分散在从预混合装置供给的预先浆中产生浆料。 主捏合装置包括由彼此面对彼此以预定距离定位的两个锥形表面限定的间隙，并围绕其中心轴线相对于彼此旋转。 通过使预浆液通过间隙而产生浆料。 利用预混合装置，在与液体一致之后将粉末分散在液体中，这抑制了粉末的损坏。 主要捏合条件只能通过调节间隙来改变，这有利于改变主捏合条件的操作。